Výsledky vyhledávání - "Candace S. Worrell"

2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:660-663

Elaboration of the SAR around a series of 2,4-diaminopyrimidines led to a number of c-Met inhibitors in which kinase selectivity was modulated by substituents appended on the C4-aminobenzamide ring and the nature of the C2-aminoaryl ring. Further lea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2f5ede7c3bb696001314f924df06f4
https://doi.org/10.1016/j.bmcl.2010.12.013

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Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group

Autor: Hong Chang, Jean Husten, Lisa D. Aimone, Thelma S. Angeles, Christine LoSardo, Karen L. Milkiewicz, Damaris Rolon-Steele, Seetha Murthy, Mark S. Albom, Jennifer Grobelny, Candace S. Worrell, Ted L. Underiner, Linda Weinberg, Bruce D. Dorsey, Kelli S. Zeigler, Sheila J. Miknyoczki

Publikováno v: Bioorganicmedicinal chemistry. 19(21)

The hepatocyte growth factor (HGF)-c-Met signaling axis is involved in the mediation of many biological activities, including angiogenesis, proliferation, cell survival, cell motility, and morphogenesis. Dysregulation of c-Met signaling (e.g., overex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e067c0d3b0becbb7b3228b634d8dc1
https://pubmed.ncbi.nlm.nih.gov/21967808

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The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity

Autor: Bruce Ruggeri, Jean Husten, Robert L. Hudkins, Allison L. Zulli, Candace S. Worrell, Mark A. Ator, Ralph E. Parchment, Natalie McGann, Hong Chang, Jennifer Grobelny, Sonya Pritchard, Sheila J. Miknyoczki, James Deibold

Publikováno v: Molecular cancer therapeutics. 6(8)

The effect of the potent and selective poly(ADP-ribose) (PAR) polymerase-1 [and PAR polymerase-2] inhibitor CEP-8983 on the ability to sensitize chemoresistant glioblastoma (RG2), rhabdomyosarcoma (RH18), neuroblastoma (NB1691), and colon carcinoma (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990d268dbb0f39d13870fa875a5028cd
https://pubmed.ncbi.nlm.nih.gov/17699724

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