Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Candace Martin"'
Autor:
Carlota Oleaga, Golareh Jalilvand, Gregg Legters, Candace Martin, Gail Ekman, Christopher W. McAleer, Christopher J. Long, James J. Hickman
Publikováno v:
APL Bioengineering, Vol 3, Iss 3, Pp 036103-036103-8 (2019)
Cardiac ischemic events increase the risk for arrhythmia, heart attack, heart failure, and death and are the leading mortality condition globally. Reperfusion therapy is the first line of treatment for this condition, and although it significantly re
Externí odkaz:
https://doaj.org/article/5f11ce822a804a7e90dd1c8e4fc6d2fa
Autor:
Christopher J. Long, Alexander S.T. Smith, Candace Martin, Yunqing Cai, Christopher W. McAleer, Sarah A. Najjar, James J. Hickman, Balaji Srinivasan, Herman H. Vandenburgh
Publikováno v:
Biotechnol Bioeng
In vitro systems that mimic organ functionality have become increasingly important tools in drug development studies. Systems that measure the functional properties of skeletal muscle are beneficial to compound screening studies and also for integrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3372ff95337a14f3dfa7f373def59984
https://doi.org/10.1002/bit.27231
https://doi.org/10.1002/bit.27231
Autor:
Carlota Oleaga, Anne Riu, Sandra Rothemund, Andrea Lavado, Christopher W. McAleer, Christopher J. Long, Keisha Persaud, Narasimhan Sriram Narasimhan, My Tran, Jeffry Roles, Carlos A. Carmona-Moran, Trevor Sasserath, Daniel H. Elbrecht, Lee Kumanchik, L. Richard Bridges, Candace Martin, Mark T. Schnepper, Gail Ekman, Max Jackson, Ying I. Wang, Reine Note, Jessica Langer, Silvia Teissier, James J. Hickman
Publikováno v:
Biomaterials. 182:176-190
Regulation of cosmetic testing and poor predictivity of preclinical drug studies has spurred efforts to develop new methods for systemic toxicity. Current in vitro assays do not fully represent physiology, often lacking xenobiotic metabolism. Functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33285a19753400fcca5f893bc71584ac
https://doi.org/10.1016/j.biomaterials.2018.07.062
https://doi.org/10.1016/j.biomaterials.2018.07.062
Autor:
Candace Martin, Xiufang Guo, Nesar Akanda, Severo Spradling, Alisha Colon, Maria Stancescu, James J. Hickman
Publikováno v:
Biomaterials. 122:179-187
Muscle spindles are sensory organs embedded in the belly of skeletal muscles that serve as mechanoreceptors detecting static and dynamic information about muscle length and stretch. Through their connection with proprioceptive sensory neurons, sensat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3024d42895e0470256eedbf7ed77ea69
https://doi.org/10.1016/j.biomaterials.2017.01.005
https://doi.org/10.1016/j.biomaterials.2017.01.005
Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics
Autor:
Mark T. Schnepper, L. Richard Bridges, Christopher W. McAleer, Christopher J. Long, Michael L. Shuler, Candace Martin, James J. Hickman, Daniel Elbrecht, Adrian Roth, Franz Schuler, Trevor Sasserath, John W. Rumsey, Ying Wang, Christoph Funk
Publikováno v:
Science Translational Medicine. 11
A pumpless, reconfigurable, multi-organ-on-a-chip system containing recirculating serum-free medium can be used to predict preclinical on-target efficacy, metabolic conversion, and measurement of off-target toxicity of drugs using functional biologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7725f69df9a5036fd561e0fc98793e
https://doi.org/10.1126/scitranslmed.aav1386
https://doi.org/10.1126/scitranslmed.aav1386
The Hekeia Gabbro in the Longwood Range of Southland is prospective for platinum group element mineralisation. Recently acquired geological and isotopic data, combined with reinterpreted aeromagnetic data, provide new constraints on the three dimensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d56b89fde9e34dfb38e4d7b06aa75ca
https://eartharxiv.org/nj23k
https://eartharxiv.org/nj23k
Autor:
Carlota, Oleaga, Golareh, Jalilvand, Gregg, Legters, Candace, Martin, Gail, Ekman, Christopher W, McAleer, Christopher J, Long, James J, Hickman
Publikováno v:
APL Bioengineering
Cardiac ischemic events increase the risk for arrhythmia, heart attack, heart failure, and death and are the leading mortality condition globally. Reperfusion therapy is the first line of treatment for this condition, and although it significantly re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7dc821a21eda1f59a9ca432d7a9f68db
https://pubmed.ncbi.nlm.nih.gov/31431939
https://pubmed.ncbi.nlm.nih.gov/31431939
Autor:
Andrea, Lavado, Xiufang, Guo, Alec St, Smith, Nesar, Akanda, Candace, Martin, Yunqing, Cai, Dan, Elbrecht, My, Tran, Jean-Paul, Bryant, Alisha, Colon, Christopher J, Long, Stephen, Lambert, Dave, Morgan, James J, Hickman
Publikováno v:
International journal of pharmacy and pharmaceutical research. 11(1)
There has been a tremendous amount of research into the causes of Amyotrophic Lateral Sclerosis (ALS), but yet very few treatment options beyond amelioration of symptoms. A holistic approach has shown anecdotal evidence of slowing disease progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::622d92f8b0778a266e0e69b4af3c9ff6
https://pubmed.ncbi.nlm.nih.gov/30637316
https://pubmed.ncbi.nlm.nih.gov/30637316
Autor:
Carlota Oleaga, Andrea Lavado, Anne Riu, Sandra Rothemund, Carlos A. Carmona‐Moran, Keisha Persaud, Andrew Yurko, Jennifer Lear, Narasimhan Sriram Narasimhan, Christopher J. Long, Frank Sommerhage, Lee Richard Bridges, Yunqing Cai, Candace Martin, Mark T. Schnepper, Arindom Goswami, Reine Note, Jessica Langer, Silvia Teissier, José Cotovio, James J. Hickman
Publikováno v:
Adv Funct Mater
The goal of human-on-a-chip systems is to capture multi-organ complexity and predict the human response to compounds within physiologically relevant platforms. The generation and characterization of such systems is currently a focal point of research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56649b7db9cc01f84898d059830af096
https://europepmc.org/articles/PMC9113405/
https://europepmc.org/articles/PMC9113405/
Alzheimer’s disease (AD) is characterized by slow, progressive neurodegeneration leading to severe neurological impairment, but current drug development efforts are limited by the lack of robust, human-based disease models. Amyloid-β (Aβ) is know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d227ecae2e67e0082fb4e275b0d5da91
https://europepmc.org/articles/PMC6051921/
https://europepmc.org/articles/PMC6051921/