Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Candace L. Graff"'
Autor:
Candace L. Graff, Gary M. Pollack
Publikováno v:
Journal of Pharmaceutical Sciences. 94:1187-1195
Nasal administration as a means of delivering therapeutic agents preferentially to the brain has gained significant recent interest. While some substrates appear to be delivered directly to the brain via this route, the mechanisms governing overall b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fe26815a479eaf22338f6176611735
https://doi.org/10.1002/jps.20318
https://doi.org/10.1002/jps.20318
Publikováno v:
Pharmaceutical Research. 22:235-244
This study was conducted to develop a physiologically relevant mathematical model for describing brain uptake and disposition of nasally administered substrates.[14C]-antipyrine, [14C]-diazepam, [3H]-sucrose, or [3H]-verapamil was administered nasall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f4420831a88d4540fb913a7cf6b49a
https://doi.org/10.1007/s11095-004-1191-5
https://doi.org/10.1007/s11095-004-1191-5
Autor:
Candace L. Graff, Gary M. Pollack
Publikováno v:
Pharmaceutical Research. 22:86-93
Experiments were performed to assess the brain distribution of [3H]-verapamil, including the influence of delivery route of inhibitor and substrate (nasal vs. systemic) on brain distribution. The anatomic location of P-glycoprotein (P-gp) at the nose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89195db116a2ce120884f64b567f79bc
https://doi.org/10.1007/s11095-004-9013-3
https://doi.org/10.1007/s11095-004-9013-3
Autor:
Gary M. Pollack, Candace L. Graff
Publikováno v:
Current Drug Metabolism. 5:95-108
The blood-brain barrier (BBB) and blood-CSF barrier (BCSFB) represent the main interfaces between the central nervous system (CNS) and the peripheral circulation. Drug exposure to the CNS is dependent on a variety of factors, including the physical b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d21edd1074ad5ba9e5c3c0437d3968c
https://doi.org/10.2174/1389200043489126
https://doi.org/10.2174/1389200043489126
Autor:
Gary M. Pollack, Candace L. Graff
Publikováno v:
Pharmaceutical Research. 20:1225-1230
Purpose. Previous literature has suggested the absence of an effective barrier between the nasal mucosa and the brain for compounds administered via the nasal route. These experiments were conducted to elucidate the role of the blood-brain barrier ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ee799dd5e3d1c1239f19b4a2af0a42c
https://doi.org/10.1023/a:1025053115583
https://doi.org/10.1023/a:1025053115583
Publikováno v:
Pharmaceutical research. 21(10)
A subpopulation of the CF-1 mouse strain (approximately 25%) lacks P-gp expression, and consequently, increased brain penetration of many substrates is observed in these animals. Mice lacking the mdr1a gene represent an important research tool to stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d7e804c42760bbbcbb5fb0a9df6116
https://pubmed.ncbi.nlm.nih.gov/15553234
https://pubmed.ncbi.nlm.nih.gov/15553234
Autor:
Candace L, Graff, Gary M, Pollack
Publikováno v:
Current drug metabolism. 5(1)
The blood-brain barrier (BBB) and blood-CSF barrier (BCSFB) represent the main interfaces between the central nervous system (CNS) and the peripheral circulation. Drug exposure to the CNS is dependent on a variety of factors, including the physical b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8b59c8ca39dbdd2d3d8edce5a6a79653
https://pubmed.ncbi.nlm.nih.gov/14965253
https://pubmed.ncbi.nlm.nih.gov/14965253
Publikováno v:
Biochemical pharmacology. 67(2)
The efflux transporter P-glycoprotein (P-gp) is an important component of the blood-brain barrier (BBB) that limits accumulation of many compounds in brain. Some opioids have been shown to interact with P-gp in vitro and in vivo. Genetic or chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f92195bdd28baba7157db8444bd2ebc
https://pubmed.ncbi.nlm.nih.gov/14698039
https://pubmed.ncbi.nlm.nih.gov/14698039
Autor:
Candace L. Graff, Gary M. Pollack
Publikováno v:
Pharmaceutical Research; Aug2003, Vol. 20 Issue 8, p1225-1230, 6p