Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Candace Black-Schaefer"'
Autor:
Tianyuan Zhang, Richard A. G. Smith, Rohinton Edalji, Yu-Gui Gu, John L. Baranowski, William J. Sanders, Bruce A. Beutel, Liping Yu, Philip J. Hajduk, Annapur Gurulingappa Shivakumar, Stephan J. Kakavas, Frank L. Wagenaar, Darlene J. Balli, Steven F. Betz, Richard F. Clark, Kenneth M. Comess, Eric J. Hebert, J. Owen McCall, Jamey Mack, Linda E. Chovan, Randy E. Metzger, Thomas F. Holzman, Anne Y. Saiki, Sarah A. Dorwin, Niru B. Soni, Mai Bui, Angela M. Nilius, Susan J. Thornewell, Cooper Curt S, Mark E. Schurdak, Michael L. Coen, Rolf Wagner, Alan S. Florjancic, Philip J. Merta, Claude G. Lerner, Charlotte Woodall, Candace Black-Schaefer, John E. Harlan, Mengli Cai, Karl A. Walter, Xenia B. Searle, Stephen W. Fesik
Publikováno v:
Chemical Biology & Drug Design. 69:395-404
As part of a fully integrated and comprehensive strategy to discover novel antibacterial agents, NMR- and mass spectrometry-based affinity selection screens were performed to identify compounds that bind to protein targets uniquely found in bacteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5518c2506c2d9a00a67d68a32abac6
https://doi.org/10.1111/j.1747-0285.2007.00521.x
https://doi.org/10.1111/j.1747-0285.2007.00521.x
Autor:
Melinda Yates, Lori J. Pease, Patrick A. Marcotte, Jennifer J. Bouska, Niru B. Soni, Daniel H. Albert, Robin R. Frey, Steven K. Davidsen, Michael L. Curtin, Keith B. Glaser, Michael R. Michaelides, Peter J. Dandliker, Asma A Ahmed, Paul Rafferty, Kent D. Stewart, Maria D Moskey, Candace Black-Schaefer, Peter F. Bousquet, H. Robin Heyman, George A. Cunha
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1246-1249
A series of substituted thienopyridine ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 2, are potent inhibitors of KDR (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0affa478acc38849cf981621ca7094cd
https://doi.org/10.1016/j.bmcl.2006.12.015
https://doi.org/10.1016/j.bmcl.2006.12.015
Autor:
Niru B. Soni, Rolf Wagner, Steve D. Pratt, Teresa A. Rosenberg, Linda E. Chovan, Darlene J. Balli, Candace Black-Schaefer, Angela M. Nilius, Philip J. Merta, Moshe Weitzberg, Mira M. Hinman, Bruce A. Beutel, Frank L. Wagenaar, Douglas Kalvin
Publikováno v:
Journal of Medicinal Chemistry. 49:4842-4856
We describe the synthesis and antibacterial activity of a series of tetracyclic naphthyridones. The members of this series act primarily via inhibition of bacterial translation and belong to the class of novel ribosome inhibitors (NRIs). In this pape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3055d76c6d0264564a99b3d72a37d9
https://doi.org/10.1021/jm060010w
https://doi.org/10.1021/jm060010w
Autor:
Richard F. Clark, Xiaoan Ruan, Xiaoling Xuei, Rolf Wagner, Ping Zhong, Caroline A. David, Steve D. Pratt, Moshe Weitzberg, Candace Black-Schaefer, Linus L. Shen, Peter J. Dandliker, Yingna Cai, Erika E. Englund, Stephan J. Kakavas, Angela M. Nilius, Niru B. Soni, Mai Bui, Melissa M. Daly, Philip J. Merta, Danli L. Towne, Bruce A. Beutel, Linda E. Chovan, Zhensheng Cao, Robert K. Hickman, Anne Y. Saiki, Claude G. Lerner
Publikováno v:
Antimicrobial Agents and Chemotherapy. 47:3831-3839
We report the discovery and characterization of a novel ribosome inhibitor (NRI) class that exhibits selective and broad-spectrum antibacterial activity. Compounds in this class inhibit growth of many gram-positive and gram-negative bacteria, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552703c8ab33220cee707975bca5b007
https://doi.org/10.1128/aac.47.12.3831-3839.2003
https://doi.org/10.1128/aac.47.12.3831-3839.2003
Publikováno v:
Journal of Computer-Aided Molecular Design. 5:323-334
Molecular modeling techniques and three-dimensional (3D) pattern analysis have been used to investigate the chemical and steric properties of compounds that inhibit transport of the plant hormone auxin. These compounds bind to a specific site on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01dc625089f95280859e1fe6089a27a9
https://doi.org/10.1007/bf00126666
https://doi.org/10.1007/bf00126666
Autor:
Kenton L. Longenecker, Bradley J. Backes, David W A Beno, James M. Trevillyan, Hing L. Sham, Hana Kopecka, Michael A. Stashko, Gregory Hamilton, Zhonghua Pei, David Madar, Stephen J. Ballaron, Bradley A. Zinker, Candace Black-Schaefer, Thomas H. Lubben, Chunqiu Lai, Thomas W. von Geldern, Anita J Kempf-Grote, Kent D. Stewart, Zhenping Tian, Amanda K Mika
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(7)
A novel series of pyrrolidine-constrained phenethylamines were developed as dipeptidyl peptidase IV (DPP4) inhibitors for the treatment of type 2 diabetes. The cyclohexene ring of lead-like screening hit 5 was replaced with a pyrrolidine to enable pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67ad812a62c9eb3983707a663206f0f
https://pubmed.ncbi.nlm.nih.gov/17276063
https://pubmed.ncbi.nlm.nih.gov/17276063
Autor:
J. Owen McCall, Bruce A. Beutel, Philip J. Hajduk, Geoffrey F. Stamper, Richard F. Clark, Yingna Cia, Kenton L. Longenecker, Elizabeth H. Fry, Candace Black-Schaefer, Clarissa G. Jakob, Cooper Curt S, Alan S. Florjancic, Claude G. Lerner, Vincent S. Stoll, Yu-Gui Gu, David D. Anderson, Tianyuan Zhang
Publikováno v:
Chemical biologydrug design. 67(1)
The D-Ala-D-Ala adding enzyme (MurF) from Streptococcus pneumoniae catalyzes the ATP-dependent formation of the UDP-MurNAc-pentapeptide, a critical component of the bacterial cell wall. MurF is a potential target for antibacterial design because it i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b992b4813e270fe71f7a85a20a6ef09
https://pubmed.ncbi.nlm.nih.gov/16492149
https://pubmed.ncbi.nlm.nih.gov/16492149
Publikováno v:
Antimicrobial agents and chemotherapy. 49(5)
The novel ribosome inhibitors (NRIs) are a broad-spectrum naphthyridine class that selectively inhibits bacterial protein synthesis (P. J. Dandliker et al., Antimicrob. Agents Chemother. 47:3831-3839, 2003). Footprinting experiments, using a range of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b497ed9fd41c1f8d6713d5f757850e
https://pubmed.ncbi.nlm.nih.gov/15855511
https://pubmed.ncbi.nlm.nih.gov/15855511
Publikováno v:
Rapid communications in mass spectrometry : RCM. 18(24)
High-throughput metabolic screening has been requested routinely to keep pace with high-throughput organic synthesis. Liquid chromatography/tandem mass spectrometry (LC/MS/MS) with a fast gradient has become the method of choice for the task due to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84088ac6ca2ae306a0f8215142d0d218
https://pubmed.ncbi.nlm.nih.gov/15565734
https://pubmed.ncbi.nlm.nih.gov/15565734
Autor:
J. Owen McCall, Claude G. Lerner, Tianyuan Zhang, Cooper Curt S, Richard F. Clark, Geoffrey F. Stamper, Yingna Cai, Candace Black-Schaefer, David D. Anderson, Philip J. Hajduk, Yu Gui Gu, Alan S. Florjancic, Bruce A. Beutel
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(1)
A novel class of MurF inhibitors was discovered and structure-activity relationship studies have led to several potent compounds with IC(50)=22 approximately 70 nM. Unfortunately, none of these potent MurF inhibitors exhibited significant antibacteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e337d43fe3605a46081e5beaa455e9fa
https://pubmed.ncbi.nlm.nih.gov/14684340
https://pubmed.ncbi.nlm.nih.gov/14684340