Signaling induced by PAR1 on breast cancer cell lines is correlating with its invasive potential

Autor: Rodríguez Norma, Lagunas Vilma, Cancino Gisela

Publikováno v: BMC Cancer, Vol 7, Iss Suppl 1, p A10 (2007)

Externí odkaz: https://doaj.org/article/c450bdd1177543bbafab56d303fe7c72

Prophylactic treatment with the c-Abl inhibitor, neurotinib, diminishes neuronal damage and the convulsive state in pilocarpine-induced mice.

Autor: Chandía-Cristi A; Department of Cellular and Molecular Biology, Pontificia Universidad Católica de Chile, Portugal 49, Santiago, Chile., Gutiérrez DA; Department of Cellular and Molecular Biology, Pontificia Universidad Católica de Chile, Portugal 49, Santiago, Chile; Millennium Institute on Immunology and Immunotherapy, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Portugal 49, Santiago, Chile., Dulcey AE; Early Translation Branch, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, USA., Lara M; Neuroscience Laboratory, Biology and Chemistry Faculty, Universidad de Santiago de Chile, Avenue Libertador Bernardo O'Higgins, Santiago 3363, Chile., Vargas L; Department of Cellular and Molecular Biology, Pontificia Universidad Católica de Chile, Portugal 49, Santiago, Chile., Lin YH; Early Translation Branch, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, USA., Jimenez-Muñoz P; Department of Cellular and Molecular Biology, Pontificia Universidad Católica de Chile, Portugal 49, Santiago, Chile., Larenas G; Department of Cellular and Molecular Biology, Pontificia Universidad Católica de Chile, Portugal 49, Santiago, Chile., Xu X; Early Translation Branch, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, USA., Wang A; Early Translation Branch, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, USA., Owens A; Early Translation Branch, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, USA., Dextras C; Early Translation Branch, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, USA., Chen Y; Early Translation Branch, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, USA., Pinto C; Department of Cellular and Molecular Biology, Pontificia Universidad Católica de Chile, Portugal 49, Santiago, Chile., Marín T; Department of Cellular and Molecular Biology, Pontificia Universidad Católica de Chile, Portugal 49, Santiago, Chile; Millennium Institute on Immunology and Immunotherapy, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Portugal 49, Santiago, Chile., Almarza-Salazar H; Department of Cellular and Molecular Biology, Pontificia Universidad Católica de Chile, Portugal 49, Santiago, Chile; Millennium Institute on Immunology and Immunotherapy, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Portugal 49, Santiago, Chile., Acevedo K; Neurology Unit of Pediatric Division, Pontificia Universidad Católica de Chile, Avenue Libertador Bernardo O'Higgins 340, Santiago, Chile., Cancino GI; Department of Cellular and Molecular Biology, Pontificia Universidad Católica de Chile, Portugal 49, Santiago, Chile., Hu X; Early Translation Branch, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, USA., Rojas P; Neuroscience Laboratory, Biology and Chemistry Faculty, Universidad de Santiago de Chile, Avenue Libertador Bernardo O'Higgins, Santiago 3363, Chile., Ferrer M; Early Translation Branch, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, USA., Southall N; Early Translation Branch, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, USA., Henderson MJ; Early Translation Branch, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, USA., Zanlungo S; Department of Gastroenterology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Avenue Libertador Bernardo O'Higgins 340, Santiago, Chile. Electronic address: szanlungo@uc.cl., Marugan JJ; Early Translation Branch, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, USA. Electronic address: maruganj@mail.nih.gov., Álvarez R A; Department of Cellular and Molecular Biology, Pontificia Universidad Católica de Chile, Portugal 49, Santiago, Chile; Millennium Institute on Immunology and Immunotherapy, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Portugal 49, Santiago, Chile. Electronic address: aalvarer@uc.cl.

Publikováno v: Cell reports [Cell Rep] 2024 May 28; Vol. 43 (5), pp. 114144. Date of Electronic Publication: 2024 Apr 23.

c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration.

Autor: Martinez A; Cell Signaling Laboratory, Department of Cell and Molecular Biology, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.; Basal Center for Aging and Regeneration, Pontificia Universidad Católica de Chile (CARE UC), Santiago 8331150, Chile., Lamaizon CM; Cell Signaling Laboratory, Department of Cell and Molecular Biology, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.; Millennium Institute on Immunology and Immunotherapy, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile., Valls C; Cell Signaling Laboratory, Department of Cell and Molecular Biology, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile., Llambi F; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Leal N; Cell Signaling Laboratory, Department of Cell and Molecular Biology, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile., Fitzgerald P; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Guy C; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Kamiński MM; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Inestrosa NC; Basal Center for Aging and Regeneration, Pontificia Universidad Católica de Chile (CARE UC), Santiago 8331150, Chile.; Center of Excellence in Biomedicine of Magallanes (CEBIMA), University of Magallanes, Punta Arenas 6210427, Chile., van Zundert B; Basal Center for Aging and Regeneration, Pontificia Universidad Católica de Chile (CARE UC), Santiago 8331150, Chile.; Institute of Biomedical Sciences, Faculty of Medicine & Faculty of Life Sciences, Universidad Andres Bello, Santiago 8370146, Chile.; Department of Neurology, University of Massachusetts Chan Medical School (UMMS), Worcester, MA 01655, USA., Cancino GI; Laboratory of Neurobiology, Department of Cell and Molecular Biology, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile., Dulcey AE; Early Translation Branch, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD 20850, USA., Zanlungo S; Department of Gastroenterology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Av. Libertador Bernardo O'Higgins 340, Santiago 8331150, Chile., Marugan JJ; Early Translation Branch, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD 20850, USA., Hetz C; Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile, Santiago 8330015, Chile.; Center for Geroscience, Brain Health and Metabolism (GERO), Santiago 8380453, Chile.; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago 8330015, Chile.; The Buck Institute for Research in Aging, Novato, CA 94945, USA., Green DR; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Alvarez AR; Cell Signaling Laboratory, Department of Cell and Molecular Biology, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.; Basal Center for Aging and Regeneration, Pontificia Universidad Católica de Chile (CARE UC), Santiago 8331150, Chile.; Millennium Institute on Immunology and Immunotherapy, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.

Publikováno v: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2023 Nov 16; Vol. 12 (11). Date of Electronic Publication: 2023 Nov 16.

The c-Abl/p73 pathway induces neurodegeneration in a Parkinson's disease model.

Autor: Marín T; Cell Signaling Laboratory, Department of Cellular and Molecular Biology, Millennium Institute on Immunology and Immunotherapy, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago 8331010, Chile., Valls C; Cell Signaling Laboratory, Department of Cellular and Molecular Biology, Millennium Institute on Immunology and Immunotherapy, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago 8331010, Chile., Jerez C; Center for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago 8580745, Chile., Huerta T; Center for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago 8580745, Chile., Elgueta D; Center for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago 8580745, Chile., Vidal RL; Center for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago 8580745, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago 8580745, Chile., Alvarez AR; Cell Signaling Laboratory, Department of Cellular and Molecular Biology, Millennium Institute on Immunology and Immunotherapy, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago 8331010, Chile., Cancino GI; Center for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago 8580745, Chile.; Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago 8331010, Chile.

Publikováno v: IBRO neuroscience reports [IBRO Neurosci Rep] 2022 Oct 19; Vol. 13, pp. 378-387. Date of Electronic Publication: 2022 Oct 19 (Print Publication: 2022).

LAR Receptor Tyrosine Phosphatase Family in Healthy and Diseased Brain.

Autor: Cornejo F; Center for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago, Chile., Cortés BI; Center for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago, Chile., Findlay GM; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Cancino GI; Center for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago, Chile.; Escuela de Biotecnología, Facultad de Ciencias, Universidad Mayor, Santiago, Chile.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2021 Dec 13; Vol. 9, pp. 659951. Date of Electronic Publication: 2021 Dec 13 (Print Publication: 2021).