Zobrazeno 1 - 10
of 557
pro vyhledávání: '"Cancer drug discovery"'
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117356- (2024)
Protein neddylation, a type of post-translational modifications, involves the transfer of the ubiquitin-like protein NEDD8 to the lysine residues of a target substrate, which is catalyzed by the NEDD8 activating enzyme (E1), NEDD8 conjugating enzyme
Externí odkaz:
https://doaj.org/article/8f51bf3e2a15428b88cdde70f8e82e8d
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/c9c0cdbf9493443cb4c9014662a3a33b
Publikováno v:
SLAS Discovery, Vol 27, Iss 2, Pp 107-113 (2022)
KRAS, the most frequently mutated oncogene in human cancers, was considered “undruggable” until the identification of small molecules that bind irreversibly to the mutant reactive cysteine at residue 12. Despite the encouraging anticancer activit
Externí odkaz:
https://doaj.org/article/55f6d9221cc340e28adac8eace267cf5
Autor:
Ahmed M. Almehdi, Sameh S. M. Soliman, Abdel-Nasser A. El-Shorbagi, Andrew D. Westwell, Rania Hamdy
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14656 (2023)
The Bcl-2 family plays a crucial role in regulating cell apoptosis, making it an attractive target for cancer therapy. In this study, a series of indole-based compounds, U1–6, were designed, synthesized, and evaluated for their anticancer activity
Externí odkaz:
https://doaj.org/article/f94cb2a173d84e54ac2899296a05e9bb
Autor:
Opeyemi Iwaloye, Paul Olamide Ottu, Femi Olawale, Olorunfemi Oyewole Babalola, Olusola Olalekan Elekofehinti, Babatomiwa Kikiowo, Abayomi Emmanuel Adegboyega, Henry Nnaemeka Ogbonna, Covenant Femi Adeboboye, Ibukun Mary Folorunso, Aderonke Elizabeth Fakayode, Moses Orimoloye Akinjiyan, Sunday Amos Onikanni, Sergey Shityakov
Publikováno v:
Informatics in Medicine Unlocked, Vol 41, Iss , Pp 101332- (2023)
The escalating prevalence of cancer on a global scale, coupled with the inadequacies of present-day therapies and the emergence of drug-resistant cancer strains, has necessitated the development of additional anticancer drugs. The traditional drug di
Externí odkaz:
https://doaj.org/article/6cb83284931b4498a720fa901f2146ec
Autor:
Dhruba Jyoti Boruah, Devarajan Kathirvelan, Kaushik Bora, Ram Awatar Maurya, Panneerselvam Yuvaraj
Publikováno v:
Results in Chemistry, Vol 5, Iss , Pp 100903- (2023)
A catalyst-free one-pot synthetic approach for the synthesis of substituted 1,2,3-triazole has been described. The reaction proceeds via the simple click chemistry as well as the formation of two new C-N bonds. A wide variety of substituted 1,2,3-tri
Externí odkaz:
https://doaj.org/article/87a1a1c1c34040e8b3d8d630230eeba8
Akademický článek
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Publikováno v:
Life and Science, Vol 3, Iss 4, Pp 12-12 (2022)
Objective: To identify potential flavonoids of Artemisia annua effective against cancer using computational approaches. Study Design: Computational approaches were used to predict the anticancer activity of flavonoids through CDRUG, comparing it with
Externí odkaz:
https://doaj.org/article/249f3cb46bac4c488857f822ee81f605
Autor:
Carolina Escardó Pereyra, Rafael Ferreira Dantas, Sabrina Baptista Ferreira, Luciano Pinho Gomes, Floriano Paes Silva-Jr
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-20 (2019)
Abstract Cancer is one of the leading causes of death around the world and although the different clinical approaches have helped to increase survival rates, incidence is still high and so its mortality. Chemotherapy is the only approach which is sys
Externí odkaz:
https://doaj.org/article/fb65b31b4db344d8ab9dac190efdc7e4
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 109, Iss , Pp 2492-2498 (2019)
Intrinsic or acquired drug resistance, adverse drug reactions and tumor heterogeneity between and within cancer patients limit the efficacy of clinical management of advanced cancers. To overcome these barriers, predictive biomarkers have recently em
Externí odkaz:
https://doaj.org/article/1c3872b74b94430c981f6d40253879bc