Výsledky vyhledávání - "Cancer Vaccines/immunology"

Tumor Resident Memory T Cells: New Players in Immune Surveillance and Therapy

Autor: Dumauthioz, N., Labiano, S., Romero, P.

Publikováno v: Frontiers in immunology, vol. 9, pp. 2076

Tissue resident memory T cells (Trm) are a subset of memory T cells mainly described in inflammation and infection settings. Their location in peripheral tissues, such as lungs, gut, or skin, makes them the earliest T cell population to respond upon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::8c82ee6b1fd1f5e256add27abb8b1986
https://serval.unil.ch/resource/serval:BIB_A1AD953828BB.P001/REF.pdf

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The era of bioengineering: how will this affect the next generation of cancer immunotherapy?

Autor: Lana E. Kandalaft, Harm-Anton Klok, Michele Graciotti, Cristiana Berti

Publikováno v: Journal of translational medicine, vol. 15, no. 1, pp. 142
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-16 (2017)
Journal of Translational Medicine

Background Immunotherapy consists of activating the patient’s immune system to fight cancer and has the great potential of preventing future relapses thanks to immunological memory. A great variety of strategies have emerged to harness the immune s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6866e76561312216063440f5505aa3
https://serval.unil.ch/resource/serval:BIB_860F405AA782.P001/REF.pdf

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Replicating viral vector platform exploits alarmin signals for potent CD8(+) T cell-mediated tumour immunotherapy

Autor: Matthias Kreuzaler, Min Lu, Stephanie Darbre, Alfred Zippelius, Daniel D. Pinschewer, Mario Kreutzfeldt, Philipp Müller, Nicolas Page, Weldy V. Bonilla, Stéphanie Favre, Sandra M. Kallert, Max Löhning, Sanjiv A. Luther, Doron Merkler, Florian Kreppel

Publikováno v: Nature Communications, Vol. 8 (2017) P. 15327
Nature Communications
Nature communications, vol. 8, pp. 15327
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte (CTLeff) responses. Conversely, the induction of protective tumour-specific CTLeff and their recruitment into the tumour remain challenging tasks. Here we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cecd39857413817068e6b7d5865400
https://archive-ouverte.unige.ch/unige:98397

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Rapid and Continued T-Cell Differentiation into Long-term Effector and Memory Stem Cells in Vaccinated Melanoma Patients

Autor: Daniel E. Speiser, Emanuela M. Iancu, Hélène Maby-El Hajjami, Laurène Cagnon, Petra Baumgaertner, Philippe O. Gannon, Samia Abed Maillard, Nathalie Rufer, Alexandre Huber

Publikováno v: Clinical cancer research, vol. 23, no. 13, pp. 3285-3296

Purpose: Patients with cancer benefit increasingly from T-cell-based therapies, such as adoptive T-cell transfer, checkpoint blockade, or vaccination. We have previously shown that serial vaccinations with Melan-A MART-1 26-35 peptide, CpG-B, and inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dfa9ef2194b254de37b593826de748e
https://pubmed.ncbi.nlm.nih.gov/27872103

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Enhanced cytotoxicity and decreased CD8 dependence of human cancer-specific cytotoxic T lymphocytes after vaccination with low peptide dose

Autor: Philippe Guillaume, Nathalie Rufer, Petra Baumgaertner, Daniel E. Speiser, Tanja Lövgren, Sébastien Wieckowski, Estelle Devevre, Immanuel F. Luescher

Publikováno v: Cancer immunology immunotherapy : CII
Cancer Immunology, Immunotherapy
Cancer Immunology, Immunotherapy, Springer Verlag, 2012, 61 (6), pp.817-826. ⟨10.1007/s00262-011-1140-1⟩
Cancer Immunology, Immunotherapy, vol. 61, no. 6, pp. 817-826

International audience; In mice, vaccination with high peptide doses generates higher frequencies of specific CD8+ T cells, but with lower avidity compared to vaccination with lower peptide doses. To investigate the impact of peptide dose on CD8+ T c

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Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients

Autor: Daniel E. Speiser, Leticia Barba, Amandine Legat, Lukas Baitsch, Nathalie Rufer, Hanifa Bouzourene, Sunil K. Raghav, Petra Baumgaertner, Pedro Romero, Bart Deplancke, Sébastien Wieckowski, Estelle Devevre

Publikováno v: Journal of Clinical Investigation, vol. 121, no. 6, pp. 2350-2360
Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2011, 121 (6), pp.2350-2360. ⟨10.1172/JCI46102⟩
The Journal of clinical investigation

International audience; In chronic viral infections, CD8⁺ T cells become functionally deficient and display multiple molecular alterations. In contrast, only little is known of self- and tumor-specific CD8⁺ T cells from mice and humans. Here we d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05fae003bc650a938f54e2ed5ba1e640
https://doi.org/10.1172/jci46102

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Single cell analysis reveals similar functional competence of dominant and nondominant CD8 T-cell clonotypes

Autor: Emanuela M. Iancu, Petra Baumgaertner, Pedro Romero, Lukas Baitsch, Sébastien Wieckowski, Nathalie Rufer, Bhawna Gupta, Daniel E. Speiser, Olivier Michielin

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 37, pp. 15318-15323

Immune protection from infectious diseases and cancer is mediated by individual T cells of different clonal origin. Their functions are tightly regulated but not yet fully characterized. Understanding the contribution of each T cell will improve the

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Rapid, high-yield production in plants of individualized idiotype vaccines for non-Hodgkin's lymphoma

Autor: Stefan Herz, Daniel Tuse, J.-E. Butler-Ransohoff, Alison A. McCormick, Susana Inogés, Victor Klimyuk, Maurizio Bendandi, Romy Kandzia, Sylvestre Marillonnet, J. Lenz, Guy Vancanneyt, A. Nickstadt, Frank Thieme, R. Fröde, Yuri Gleba, A. Lopez-Diaz de Cerio, Helena Villanueva, Elena Soria

Publikováno v: Annals of Oncology. 21:2420-2427

BACKGROUND: Animal and clinical studies with plant-produced single-chain variable fragment lymphoma vaccines have demonstrated specific immunogenicity and safety. However, the expression levels of such fragments were highly variable and required comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d518aed726304ae95327ce308b6ee4
https://doi.org/10.1093/annonc/mdq256

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Fine analysis of spontaneous MAGE-C1/CT7–specific immunity in melanoma patients

Autor: Davide Soldini, Lotta von Boehmer, Alexander Knuth, Natko Nuber, Holger Moch, Claudia Matter, Jean-Marie Tiercy, Reinhard Dummer, Alessandra Curioni-Fontecedro, Maries van den Broek

Publikováno v: Proceedings of the National Academy of Sciences, Vol. 107, No 34 (2010) pp. 15187-15192

Cancer/testis (CT) antigens represent prime candidates for immunotherapy in cancer patients, because their expression is restricted to cancer cells and germ cells of the testis. MAGE-C1/CT7 is a CT antigen that is highly expressed in several types of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e972dd290fabee0eefec9942f74df4
https://doi.org/10.1073/pnas.1002155107

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