Recovery of respiratory function in mdx mice co-treated with neutralizing interleukin-6 receptor antibodies and Urocortin-2

Autor: Burns, David P., Canavan, Leonie, Rowland, Jane, O'Flaherty, Robin, Brannock, Molly, Drummond, Sarah E., O'Malley, Dervla, Edge, Deirdre, O'Halloran, Ken D.

KEY POINTS: Impaired ventilatory capacity and diaphragm muscle weakness are prominent features of Duchenne muscular dystrophy, with strong evidence of attendant systemic and muscle inflammation. We performed a 2‐week intervention in young wild‐ty

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https://hdl.handle.net/10468/6742

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Recovery of respiratory function in mdx mice co-treated with neutralizing interleukin-6 receptor antibodies and urocortin-2.

Autor: Burns DP; Department of Physiology, School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland., Canavan L; Department of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, the University of Dublin, Dublin, Ireland., Rowland J; Department of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, the University of Dublin, Dublin, Ireland., O'Flaherty R; Department of Physiology, School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland., Brannock M; Department of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, the University of Dublin, Dublin, Ireland., Drummond SE; Department of Physiology, School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland., O'Malley D; Department of Physiology, School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland., Edge D; Department of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, the University of Dublin, Dublin, Ireland., O'Halloran KD; Department of Physiology, School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland.

Publikováno v: The Journal of physiology [J Physiol] 2018 Nov; Vol. 596 (21), pp. 5175-5197. Date of Electronic Publication: 2018 Oct 03.