The distance formula in algebraic spacetime theories

Autor: Canarutto, D., Minguzzi, E.

Publikováno v: J. Phys.: Conf. Ser. 1275 (2019) 012045

The Lorentzian distance formula, conjectured several years ago by Parfionov and Zapatrin, has been recently proved by the second author. In this work we focus on the derivation of an equivalent expression in terms of the geometry of 2-spinors by usin

Externí odkaz: http://arxiv.org/abs/1902.00591

Author Correction: Genotoxic effects of base and prime editing in human hematopoietic stem cells.

Autor: Fiumara M; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Ferrari S; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy. ferrari.samuele@hsr.it.; Vita-Salute San Raffaele University, Milan, Italy. ferrari.samuele@hsr.it., Omer-Javed A; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Beretta S; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Albano L; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Canarutto D; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, Milan, Italy., Varesi A; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Gaddoni C; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Brombin C; University Center for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy., Cugnata F; University Center for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy., Zonari E; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Naldini MM; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Barcella M; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Gentner B; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Merelli I; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; National Research Council, Institute for Biomedical Technologies, Segrate, Italy., Naldini L; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy. naldini.luigi@hsr.it.; Vita-Salute San Raffaele University, Milan, Italy. naldini.luigi@hsr.it.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2024 Jun; Vol. 42 (6), pp. 986.

Early skeletal outcomes after hematopoietic stem and progenitor cell gene therapy for Hurler syndrome.

Autor: Consiglieri G; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy.; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy., Tucci F; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., De Pellegrin M; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Guerrini B; 'Vita-Salute' San Raffaele University, 20132 Milan, Italy., Cattoni A; Paediatrics, IRCCS San Gerardo dei Tintori Foundation, 20900 Monza, Italy.; School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy., Risca G; Bicocca Bioinformatics Biostatistics and Bioimaging B4 Center, School of Medicine and Surgery, University of Milano-Bicocca, 20854 Vedano al Lambro, Italy., Scarparo S; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Sarzana M; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Pontesilli S; Neuroradiology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Mellone R; Radiology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Gasperini S; Paediatrics, IRCCS San Gerardo dei Tintori Foundation, 20900 Monza, Italy., Galimberti S; Bicocca Bioinformatics Biostatistics and Bioimaging B4 Center, School of Medicine and Surgery, University of Milano-Bicocca, 20854 Vedano al Lambro, Italy.; Units of Neurology and Neurophysiology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Silvani P; Anesthesia and Critical Care, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Filisetti C; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy.; 'Vita-Salute' San Raffaele University, 20132 Milan, Italy., Darin S; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Forni G; Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy., Miglietta S; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Santi L; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Facchini M; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Corti A; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Fumagalli F; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Cicalese MP; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy.; 'Vita-Salute' San Raffaele University, 20132 Milan, Italy., Calbi V; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Migliavacca M; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Barzaghi F; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Ferrua F; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Gallo V; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Recupero S; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Canarutto D; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Doglio M; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Tedesco L; Paediatrics, IRCCS San Gerardo dei Tintori Foundation, 20900 Monza, Italy., Volpi N; Department of Life Sciences, University of Modena and Reggio Emilia, Laboratory of Biochemistry and Glycobiology, 41125 Modena, Italy., Rovelli A; Paediatrics, IRCCS San Gerardo dei Tintori Foundation, 20900 Monza, Italy., la Marca G; Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy.; Newborn Screening, Clinical Chemistry and Pharmacology Laboratory, Meyer Children's Hospital IRCCS, 50139 Florence, Italy., Valsecchi MG; Bicocca Bioinformatics Biostatistics and Bioimaging B4 Center, School of Medicine and Surgery, University of Milano-Bicocca, 20854 Vedano al Lambro, Italy.; Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy., Zancan S; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Ciceri F; 'Vita-Salute' San Raffaele University, 20132 Milan, Italy.; Department of Haematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Naldini L; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy.; 'Vita-Salute' San Raffaele University, 20132 Milan, Italy., Baldoli C; Neuroradiology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Parini R; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy., Gentner B; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy.; Ludwig Institute for Cancer Research and Department of Oncology, University of Lausanne (UNIL) and Lausanne University Hospital (CHUV), 1015 Lausanne, Switzerland., Aiuti A; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy.; 'Vita-Salute' San Raffaele University, 20132 Milan, Italy., Bernardo ME; Pediatric Immunohematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), 20132 Milan, Italy.; 'Vita-Salute' San Raffaele University, 20132 Milan, Italy.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 May; Vol. 16 (745), pp. eadi8214. Date of Electronic Publication: 2024 May 01.

Unbiased assessment of genome integrity and purging of adverse outcomes at the target locus upon editing of CD4 ⁺ T-cells for the treatment of Hyper IgM1.

Autor: Canarutto D; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Università Vita-Salute San Raffaele, Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, Milan, Italy., Asperti C; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Vavassori V; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Porcellini S; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Rovelli E; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Paulis M; Humanitas Clinical and Research Center IRCCS, Milan, Italy.; UOS Milan Unit, Istituto di Ricerca Genetica e Biomedica (IRGB), CNR, Milan, Italy., Ferrari S; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Varesi A; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Fiumara M; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Jacob A; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Sergi Sergi L; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Visigalli I; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ferrua F; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, Milan, Italy., González-Granado LI; Unidad de Immunodeficiencias Primarias y la Unidad de Hematología y Oncología Pediátrica, Instituto de Investigacíon Hospital 12 de Octubre, Madrid, Spain., Lougaris V; University of Brescia, Brescia, Italy., Finocchi A; Academic Department of Pediatrics (DPUO), Research Unit of Clinical Immunology and Vaccinology, Bambino Gesú Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy., Villa A; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; UOS Milan Unit, Istituto di Ricerca Genetica e Biomedica (IRGB), CNR, Milan, Italy., Radrizzani M; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Naldini L; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Università Vita-Salute San Raffaele, Milan, Italy.

Publikováno v: The EMBO journal [EMBO J] 2023 Dec 01; Vol. 42 (23), pp. e114188. Date of Electronic Publication: 2023 Nov 02.

Scalable GMP-compliant gene correction of CD4+ T cells with IDLV template functionally validated in vitro and in vivo .

Autor: Asperti C; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Hospital, 20132 Milan, Italy., Canarutto D; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Hospital, 20132 Milan, Italy.; Vita-Salute San Raffaele University, 20132 Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Hospital, 20132 Milan, Italy., Porcellini S; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Hospital, 20132 Milan, Italy., Sanvito F; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Hospital, 20132 Milan, Italy.; Pathology Unit, IRCCS San Raffaele Hospital, 20132 Milan, Italy., Cecere F; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Hospital, 20132 Milan, Italy., Vavassori V; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Hospital, 20132 Milan, Italy., Ferrari S; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Hospital, 20132 Milan, Italy., Rovelli E; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Hospital, 20132 Milan, Italy., Albano L; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Hospital, 20132 Milan, Italy., Jacob A; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Hospital, 20132 Milan, Italy., Sergi Sergi L; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Hospital, 20132 Milan, Italy., Montaldo E; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Hospital, 20132 Milan, Italy., Ferrua F; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Hospital, 20132 Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Hospital, 20132 Milan, Italy., González-Granado LI; Primary Immunodeficiencies Unit, Department of Pediatrics, Research Institute Imas12 (i+12), Hospital 12 de Octubre, 28041 Madrid, Spain.; School of Medicine, Complutense University, 28015 Madrid, Spain., Lougaris V; Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia and ASST-Spedali Civili of Brescia, 25123 Brescia, Italy., Badolato R; Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia and ASST-Spedali Civili of Brescia, 25123 Brescia, Italy., Finocchi A; Academic Department of Pediatrics (DPUO), Research Unit of Clinical Immunology and Vaccinology, Bambino Gesú Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, 00165 Rome, Italy., Villa A; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Hospital, 20132 Milan, Italy.; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale Delle Ricerche (IRGB-CNR), 20138 Unit of Milan, Italy., Radrizzani M; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Hospital, 20132 Milan, Italy., Naldini L; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Hospital, 20132 Milan, Italy.; Vita-Salute San Raffaele University, 20132 Milan, Italy.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2023 Aug 23; Vol. 30, pp. 546-557. Date of Electronic Publication: 2023 Aug 23 (Print Publication: 2023).