Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Canadian Critical Care Translational Biology Group"'
Autor:
Daphnée Lamarche, Jennie Johnstone, Nicole Zytaruk, France Clarke, Lori Hand, Dessi Loukov, Jake C. Szamosi, Laura Rossi, Louis P. Schenck, Chris P. Verschoor, Ellen McDonald, Maureen O. Meade, John C. Marshall, Dawn M. E. Bowdish, Tim Karachi, Diane Heels-Ansdell, Deborah J. Cook, Michael G. Surette, for the PROSPECT Investigators, Canadian Critical Care Trials Group, Canadian Critical Care Translational Biology Group
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background Host-associated microbial communities have important roles in tissue homeostasis and overall health. Severe perturbations can occur within these microbial communities during critical illness due to underlying diseases and clinical
Externí odkaz:
https://doaj.org/article/20563f38c65940f0b3e687d0e4b2a004
Autor:
Marc T Avey, David Moher, Katrina J Sullivan, Dean Fergusson, Gilly Griffin, Jeremy M Grimshaw, Brian Hutton, Manoj M Lalu, Malcolm Macleod, John Marshall, Shirley H J Mei, Michael Rudnicki, Duncan J Stewart, Alexis F Turgeon, Lauralyn McIntyre, Canadian Critical Care Translational Biology Group
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166733 (2016)
Incomplete reporting of study methods and results has become a focal point for failures in the reproducibility and translation of findings from preclinical research. Here we demonstrate that incomplete reporting of preclinical research is not limited
Externí odkaz:
https://doaj.org/article/16c593cddf6748c39a219f0d77c22d04
Autor:
Lauralyn A McIntyre, David Moher, Dean A Fergusson, Katrina J Sullivan, Shirley H J Mei, Manoj Lalu, John Marshall, Malcolm Mcleod, Gilly Griffin, Jeremy Grimshaw, Alexis Turgeon, Marc T Avey, Michael A Rudnicki, Mazen Jazi, Jason Fishman, Duncan J Stewart, Canadian Critical Care Translational Biology Group
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147170 (2016)
The Acute Respiratory Distress Syndrome (ARDS) is a devastating clinical condition that is associated with a 30-40% risk of death, and significant long term morbidity for those who survive. Mesenchymal stromal cells (MSC) have emerged as a potential
Externí odkaz:
https://doaj.org/article/8f1eef8c46e247249df355031cf2ada2
Autor:
Amirali Mirsajadi, BSc, Dustin Erickson, BSc, Soumya Alias, MSc, Logan Froese, PhD, Amanjyot Singh Sainbhi, BEng, Alwyn Gomez, MD, Raju Majumdar, BSc, Isuru Herath, BEng, Maggie Wilson, RN, MSc, Ryan Zarychanski, MD, MSc, Frederick A. Zeiler, MD, PhD, Asher A. Mendelson, MD, PhD, on behalf of the Microvasclar Monitoring in Circulatory Shock and Sepsis (MiMICSS) Investigators and the Canadian Critical Care Translational Biology Group, Asher Mendelson, Frederick Zeiler, Ryan Zarychanski, Sylvain Lother, Gloria Vazquez Grande, Olawale Ayilara, J Gordon Boyd, David Maslove, Stephanie Sibley
Publikováno v:
Critical Care Explorations, Vol 6, Iss 7, p e1111 (2024)
IMPORTANCE:. Microvascular autoregulation (MA) maintains adequate tissue perfusion over a range of arterial blood pressure (ABP) and is frequently impaired in critical illness. MA has been studied in the brain to derive personalized hemodynamic targe
Externí odkaz:
https://doaj.org/article/990562b7dabf40779c301c365c943be5
Autor:
Mohammad M. Banoei, Chel Hee Lee, James Hutchison, William Panenka, Cheryl Wellington, David S. Wishart, Brent W. Winston, the Canadian biobank, database for Traumatic Brain Injury (CanTBI) investigators, the Canadian Critical Care Translational Biology Group (CCCTBG), the Canadian Traumatic Brain Injury Research, Clinical Network (CTRC)
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-15 (2023)
Abstract Background Prognostication is very important to clinicians and families during the early management of severe traumatic brain injury (sTBI), however, there are no gold standard biomarkers to determine prognosis in sTBI. As has been demonstra
Externí odkaz:
https://doaj.org/article/d4b7736cb1c043eca6df6e1e6ba4dcc7
Autor:
MengQi Zhang, Dean A. Fergusson, Rahul Sharma, Ciel Khoo, Asher A. Mendelson, Braedon McDonald, Kimberly F. Macala, Neha Sharma, Sean E. Gill, Kirsten M. Fiest, Christian Lehmann, Risa Shorr, Forough Jahandideh, Stephane L. Bourque, Patricia C. Liaw, Alison Fox-Robichaud, Manoj M. Lalu, on behalf of the Canadian Critical Care Translational Biology Group, the Sepsis Canada National Preclinical Sepsis Platform
Publikováno v:
Systematic Reviews, Vol 12, Iss 1, Pp 1-9 (2023)
Abstract Background The importance of investigating sex- and gender-dependent differences has been recently emphasized by major funding agencies. Notably, the influence of biological sex on clinical outcomes in sepsis is unclear, and observational st
Externí odkaz:
https://doaj.org/article/19f1ce8a2d3b487d9eec9135366362f3
Autor:
Mohammad M. Banoei, Lauralyn A. McIntyre, Duncan J. Stewart, Shirley H. J. Mei, David Courtman, Irene Watpool, John Granton, John Marshall, Claudia dos Santos, Keith R. Walley, Kenny Schlosser, Dean A. Fergusson, Brent W. Winston, on behalf of Canadian Critical Care Trials Group (CCCTG), on behalf of Canadian Critical Care Translational Biology Group (CCCTBG)
Publikováno v:
Metabolites, Vol 13, Iss 11, p 1142 (2023)
Sepsis is the result of an uncontrolled host inflammatory response to infection that may lead to septic shock with multiorgan failure and a high mortality rate. There is an urgent need to improve early diagnosis and to find markers identifying those
Externí odkaz:
https://doaj.org/article/3455d13757b24114a6f29090a6d96d18
Autor:
Victoria T Hunniford, Agnes Grudniewicz, Dean A Fergusson, Joshua Montroy, Emma Grigor, Casey Lansdell, Manoj M Lalu, On behalf of The Canadian Critical Care Translational Biology Group
Publikováno v:
eLife, Vol 12 (2023)
Background: Multicentric approaches are widely used in clinical trials to assess the generalizability of findings, however, they are novel in laboratory-based experimentation. It is unclear how multilaboratory studies may differ in conduct and result
Externí odkaz:
https://doaj.org/article/c3bacf29ec004c61ba79555030c592f1
Autor:
Typhaine Gris, Patrick Laplante, Paméla Thebault, Romain Cayrol, Ahmed Najjar, Benjamin Joannette-Pilon, Frédéric Brillant-Marquis, Elsa Magro, Shane W. English, Réjean Lapointe, Michel Bojanowski, Charles L. Francoeur, Jean-François Cailhier, on behalf of the Canadian Critical Care Translational Biology Group
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-16 (2019)
Abstract Background Aneurysmal subarachnoid hemorrhage (SAH) is a catastrophic disease with devastating consequences, including a high mortality rate and severe disabilities among survivors. Inflammation is induced following SAH, but the exact role a
Externí odkaz:
https://doaj.org/article/cf807618ddec4f168a80da39fe6b4434
Autor:
MengQi Zhang, BSc, Joshua Montroy, MSc, Rahul Sharma, HBSc, Dean A. Fergusson, MHA, PhD, Asher A. Mendelson, MD, PhD, FRCPC, Kimberly F. Macala, MD, FRCPC, Stephane L. Bourque, PhD, Jared M. Schlechte, BSc, Mikaela K. Eng, MSc, Braedon McDonald, MD, PhD, FRCPC, Sean E. Gill, PhD, Kirsten M. Fiest, PhD, Patricia C. Liaw, MSc, PhD, Alison Fox-Robichaud, MSc, MD, FRCPC, Manoj M. Lalu, MD, PhD, FRCPC, on behalf of the Canadian Critical Care Translational Biology Group and the Sepsis Canada National Preclinical Sepsis Platform
Publikováno v:
Critical Care Explorations, Vol 3, Iss 6, p e0433 (2021)
OBJECTIVES:. Preclinical studies provide an opportunity to evaluate the relationship between sex and sepsis, and investigate underlying mechanisms in a controlled experimental environment. The objective of our systematic review was to assess the impa
Externí odkaz:
https://doaj.org/article/3d91592aef26469088861c5e8ddfd0d5