Zobrazeno 1 - 10 of 669 pro vyhledávání: '"Canada's Michael Smith Genome Sciences Centre"'
1
Integrated genomic and molecular characterization of cervical cancer
Autor: Cancer Genome Atlas Research Network, Albert Einstein College of Medicine, Analytical Biological Services, Barretos Cancer Hospital, Baylor College of Medicine, Beckman Research Institute of City of Hope, Buck Institute for Research on Aging, Canada's Michael Smith Genome Sciences Centre, Harvard Medical School, Helen F. Graham Cancer Center &Research Institute at Christiana Care Health Services, HudsonAlpha Institute for Biotechnology, ILSbio, LLC, Indiana University School of Medicine, Institute of Human Virology, Institute for Systems Biology, International Genomics Consortium, Leidos Biomedical, Massachusetts General Hospital, McDonnell Genome Institute at Washington University, Medical College of Wisconsin, Medical University of South Carolina, Memorial Sloan Kettering Cancer Center, Montefiore Medical Center, NantOmics, National Cancer Institute, National Hospital, Abuja, Nigeria, National Human Genome Research Institute, National Institute of Environmental Health Sciences, National Institute on Deafness &Other Communication Disorders, Ontario Tumour Bank, London Health Sciences Centre, Ontario Tumour Bank, Ontario Institute for Cancer Research, Ontario Tumour Bank, The Ottawa Hospital, Oregon Health &Science University, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, SRA International, St Joseph's Candler Health System, Eli &Edythe L. Broad Institute of Massachusetts Institute of Technology &Harvard University, Research Institute at Nationwide Children's Hospital, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, University of Bergen, University of Texas MD Anderson Cancer Center, University of Abuja Teaching Hospital, University of Alabama at Birmingham, University of California, Irvine, University of California Santa Cruz, University of Kansas Medical Center, University of Lausanne, University of New Mexico Health Sciences Center, University of North Carolina at Chapel Hill, University of Oklahoma Health Sciences Center, University of Pittsburgh, University of São Paulo, Ribeir ão Preto Medical School, University of Southern California, University of Washington, University of Wisconsin School of Medicine &Public Health, Van Andel Research Institute, Washington University in St Louis
Publikováno v: Nature, vol 543, iss 7645
Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary cervical cancers, one of the largest comprehensive genomic studies of cervical cancer to date
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0e44b69213d674d6e55a8352e5ba7565
https://escholarship.org/uc/item/1j13q58s
Zobrazit plný text záznamu
2
Single-cell analysis of autophagy activity in normal and de novo transformed human mammary cells
Autor: Sylvain Lefort, Véronique Maguer-Satta, Sneha Balani, Sharon M. Gorski, Davide Pellacani, Boris Guyot, Connie J. Eaves
Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-77347-w⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-77347-w⟩
Assessment of autophagy activity has historically been limited to investigations of fixed tissue or bulk cell populations. To address questions of heterogeneity and relate measurements to functional properties of viable cells isolated from primary ti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6cb096421ad3aae9958f01d4251b359
https://hal.archives-ouvertes.fr/hal-03040464/document
Zobrazit plný text záznamu
3
Transient DNMT3L Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast
Autor: Yoyo Chih-Yun Yu, Tony ZK Hui, Tzu-Hao Kao, Hung-Fu Liao, Chih-Yi Yang, Chia-Chun Hou, Hsin-Ting Hsieh, Jen-Yun Chang, Yi-Tzang Tsai, Marina Pinskaya, Kai-Chien Yang, Yet-Ran Chen, Antonin Morillon, Mong-Hsun Tsai, Shau-Ping Lin
Publikováno v: Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Frontiers in Cell and Developmental Biology, Frontiers media, 2020, 8, pp.103. ⟨10.3389/fcell.2020.00103⟩
International audience; Global heterochromatin reduction, which is one of the hallmarks of senescent cells, is associated with reduced transposable element repression and increased risk of chromatin instability. To ensure genomic integrity, the irrep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92cc99cee2267e25215fed870d621e78
https://doi.org/10.3389/fcell.2020.00103
Zobrazit plný text záznamu
4
Complete Chloroplast Genome Sequence of an Engelmann Spruce (Picea engelmannii, Genotype Se404-851) from Western Canada
Autor: Lauren Coombe, S. Austin Hammond, Shaun D. Jackman, Carol Ritland, Heather Kirk, Trevor Doerksen, Barry Jaquish, Helen McDonald, Inanc Birol, Jean Bousquet, Richard A. Moore, Steven J.M. Jones, Andrew J. Mungall, Yongjun Zhao, Diana Lin, Kristina K. Gagalova, René L. Warren, Joerg Bohlmann, Pawan Pandoh
Publikováno v: Microbiology Resource Announcements
Microbiology Resource Announcements, American Society for Microbiology, 2019, 8 (24), ⟨10.1128/MRA.00382-19⟩
Engelmann spruce ( Picea engelmannii ) is a conifer found primarily on the west coast of North America. Here, we present the complete chloroplast genome sequence of Picea engelmannii genotype Se404-851. This chloroplast sequence will benefit future c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2161ab649fa7ae0b2dd73d315d46e8ad
https://hal.umontpellier.fr/hal-02746625
Zobrazit plný text záznamu
5
A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B
Autor: Marcel B. Bally, Fan Zhang, Nancy Erro Go, Steven J.M. Jones, Jing Xu, A. M. Hannigan, Lubomir Vezenkov, Courtney Choutka, Kevin C. Yang, R. N. Guay-Ross, S. Loo, Wieslawa H. Dragowska, Damien Bosc, Sharon M. Gorski, Tom A. Pfeifer, Nicolette S. Honson, Suzana Kovacic, Martin E. Gleave, Guoying Chen, Jianghong An, Robert N. Young, Svetlana Bortnik, Ada W. Y. Leung, P. G. K. Clark
Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.11653. ⟨10.1038/s41598-018-29900-x⟩
The cysteine protease ATG4B is a key component of the autophagy machinery, acting to proteolytically prime and recycle its substrate MAP1LC3B. The roles of ATG4B in cancer and other diseases appear to be context dependent but are still not well under
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec4c1e5752a839a23a75f0139971545
http://europepmc.org/articles/PMC6076261
Zobrazit plný text záznamu
6
Machine learning: Supervised methods, SVM and kNN
Autor: Bzdok, Danilo, Krzywinski, Martin, Altman, Naomi
Publikováno v: Nature Methods
Nature Methods, 2018, pp.1-6
Nature Methods, Nature Publishing Group, 2018, pp.1-6
International audience; In supervised learning, a set of input variables, such as bloodmetabolite or gene expression levels, are used to predict aquantitative response variable like hormone level or a qualitative onesuch as healthy versus diseased in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6305917f65a835c54820ef634b88063d
https://hal.science/hal-01657491
Zobrazit plný text záznamu
7
Statistics versus Machine Learning
Autor: Danilo Bzdok, Martin Krzywinski, Naomi Altman
Publikováno v: Nature Methods
Nature Methods, 2018, 15, pp.233-234
Nature Methods, Nature Publishing Group, 2018, 15, pp.233-234
International audience; Two major goals in the study of biological systems are inference andprediction. Inference creates a mathematical model of the datageneration process to formalize our understanding or test ahypothesis about how the system behav
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ba4497bce41293ee4b839a97be27a3
https://hal.science/hal-01723223
Zobrazit plný text záznamu
9
On the representation of de Bruijn graphs
Autor: Shaun D. Jackman, Paul Medvedev, Jared T. Simpson, Rayan Chikhi, Antoine Limasset
Publikováno v: Journal of Computational Biology
Journal of Computational Biology, Mary Ann Liebert, 2015, 22 (5), pp.336-352. ⟨10.1089/cmb.2014.0160⟩
Journal of Computational Biology, 2015, 22 (5), pp.336-352. ⟨10.1089/cmb.2014.0160⟩
The de Bruijn graph plays an important role in bioinformatics, especially in the context of de novo assembly. However, the representation of the de Bruijn graph in memory is a computational bottleneck for many assemblers. Recent papers proposed a nav
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd620a4079e0c14a78215927f22d74c
http://arxiv.org/abs/1401.5383
Zobrazit plný text záznamu
10
Analysis of the genome and transcriptome of [i]Cryptococcus neoformans[/i] var.[i] grubii[/i] reveals complex RNA expression and microevolution leading to virulence attenuation
Autor: Lukasz Kozubowski, Kaustuv Sanyal, Larry D. Mesner, Kate L. Ormerod, Yuan Chen, Frédérique Moyrand, Nandita Mullapudi, John R. Perfect, Ian A. Wood, Guilhem Janbon, James A. Fraser, James W. Kronstad, Eve W. L. Chow, Cécile Neuvéglise, Jacqueline E. Schein, Piotr A. Mieczkowski, R. Blake Billmyre, Sharvari Gujja, Gautam Chatterjee, Alexander Idnurm, Yong Sun Bahn, Marco A. Marra, Carolin Wollschlaeger, Claude Gaillardin, Chung-Chau Hon, Steven J.M. Jones, François Brunel, Kirsten Nielsen, Edmond J. Byrnes, Sara Gonzalez-Hilarion, Damien Paulet, Caroline Proux, Chinnappa D. Kodira, Christina A. Cuomo, Joseph Heitman, Jean Yves Coppée, Vikas Yadav, Kimberly J. Gerik, Yen-Ping Hsueh, Woei Lam, Qiandong Zeng, Giuseppe Ianiri, Carol S. Newlon, Weidong Chen, Jason E. Stajich, Jennifer K. Lodge, Sheng Sun, Tristan Rossignol, Joyce L. Hamlin, Jonathan M. Goldberg, Fred S. Dietrich, Anna Floyd-Averette
Publikováno v: PLoS Genetics
PLoS Genetics, 2014, 10 (4), ⟨10.1371/journal.pgen.1004261⟩
Plos Genetics 4 (10), . (2014)
PLoS Genetics, Public Library of Science, 2014, 10 (4), ⟨10.1371/journal.pgen.1004261⟩
PLoS Genetics, Vol 10, Iss 4, p e1004261 (2014)
Janbon, G; Ormerod, KL; Paulet, D; Byrnes, EJ; Yadav, V; Chatterjee, G; et al.(2014). Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation. PLoS Genetics, 10(4). doi: 10.1371/journal.pgen.1004261. UC Riverside: Retrieved from: http://www.escholarship.org/uc/item/0zm5n7sx
Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than 600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties (i.e. grubii and neoformans, respectively). Here, we sequenced the genom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449ef2968dc657034254e87f7478302c
https://hal.science/hal-01204377
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje