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pro vyhledávání: '"Can-tang Zhang"'
Autor:
Xia-yin Cao, Yi Liu, Jia-shuo Kan, Xin-xing Huang, Piniel Alphayo Kambey, Can-tang Zhang, Jin Gao
Publikováno v:
Brain Research Bulletin, Vol 212, Iss , Pp 110970- (2024)
Parkinson’s disease (PD) is a severe neurodegenerative disease associated with the loss of dopaminergic (DA) neurons in the substantia nigra (SN). Although its pathogenesis remains unclear, microglia-mediated neuroinflammation significantly contrib
Externí odkaz:
https://doaj.org/article/abc3ad7dc0754b91bbf1e4deeb407c0a
Autor:
Can-tang Zhang, Deng-li Qin, Xia-yin Cao, Jia-shuo Kan, Xin-xing Huang, Dian-shuai Gao, Jin Gao
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107049- (2023)
Summary: Parkinson’s disease (PD) is a neurodegenerative disease characterized by selective loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). We recently reported that Six2 could reverse the degeneration of DA neurons
Externí odkaz:
https://doaj.org/article/11ccd750bf2e49abb26f33b1bd64b375
Publikováno v:
Neuroscience Letters. 760:136088
Glial cell line-derived neurotrophic factor (GDNF) played critical roles in the survival and repair of dopaminergic (DA) neurons. Transcription factor Six2 could repair injured DA cells by promoting the expression of GDNF, however, the underlying mol