Fucoidan Alleviates Renal Fibrosis in Diabetic Kidney Disease via Inhibition of NLRP3 Inflammasome-Mediated Podocyte Pyroptosis

Autor: Mei-Zi Wang, Jie Wang, Dong-Wei Cao, Yue Tu, Bu-Hui Liu, Can-Can Yuan, Huan Li, Qi-Jun Fang, Jia-Xin Chen, Yan Fu, Bing-Ying Wan, Zi-Yue Wan, Yi-Gang Wan, Guo-Wen Wu

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Background: Fucoidan (FPS) has been widely used to treat renal fibrosis (RF) in patients with diabetic kidney disease (DKD); however, the precise therapeutic mechanisms remain unclear. Recently, research focusing on inflammation-derived podocyte pyro

Externí odkaz: https://doaj.org/article/e381d36e183c40d484336a4e994eea96

Fucoidan Ameliorates Renal Injury-Related Calcium-Phosphorus Metabolic Disorder and Bone Abnormality in the CKD–MBD Model Rats by Targeting FGF23-Klotho Signaling Axis

Autor: Bu-Hui Liu, Fee-Lan Chong, Can-Can Yuan, Ying-Lu Liu, Hai-Ming Yang, Wen-Wen Wang, Qi-Jun Fang, Wei Wu, Mei-Zi Wang, Yue Tu, Zi-Yue Wan, Yi-Gang Wan, Guo-Wen Wu

Publikováno v: Frontiers in Pharmacology, Vol 11 (2021)

Background: Recently, chronic kidney disease (CKD)-mineral and bone disorder (MBD) has become one of common complications occurring in CKD patients. Therefore, development of a new treatment for CKD–MBD is very important in the clinic. In China, Fu

Externí odkaz: https://doaj.org/article/2389f7e96d774fad892e1e1ff0c5d5d5

[Molecular regulatory mechanisms of hypoxia-inducible factor and interventional effect of Chinese herbal medicine].

Autor: Bu-Hui L; Nephrology Division,Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 210029,China Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine Nanjing 210008,China., Mei-Zi W; Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine Nanjing 210008,China., Wei S; Nephrology Division,Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 210029,China., Yi-Gang W; Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School Nanjing 210008,China., Wei WU; Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School Nanjing 210008,China., Qi-Jun F; Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine Nanjing 210008,China., Wen-Wen W; Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine Nanjing 210008,China., Hong-Yun Y; Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine Nanjing 210008,China., Can-Can Y; Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine Nanjing 210008,China., Ying-Lu L; Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School Nanjing 210008,China., Yue TU; Department of Traditional Chinese Medicine Health Preservation,Acupuncture and Moxibustion and Massage College·Health Preservation and Rehabilitation College,Nanjing University of Chinese Medicine Nanjing 210023,China., Fee-Lan C; The School of Pharmacy,Management and Science University Shah Alam 40100,Malaysia.

Publikováno v: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2020 Oct; Vol. 45 (20), pp. 4805-4811.