Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Can M. Sungur"'
Autor:
Can M. Sungur, Qiankun Wang, Ayşe N. Ozantürk, Hongbo Gao, Aaron J. Schmitz, Marina Cella, Wayne M. Yokoyama, Liang Shan
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
The role of NK cells against HIV-1 infections remains to be elucidated in vivo. While humanized mouse models potentially could be used to directly evaluate human NK cell responses during HIV-1 infection, improved functional development of human NK ce
Externí odkaz:
https://doaj.org/article/9b0131221adb45cb99de54bafcf1897f
Autor:
Can M. Sungur
Publikováno v:
ACR Open Rheumatology, Vol 3, Iss 8, Pp 578-580 (2021)
With increasing numbers of patients with rheumatoid arthritis achieving sustained remission, medication withdrawal is an important consideration to reduce polypharmacy and associated adverse events. An article from the journal Arthritis & Rheumatolog
Externí odkaz:
https://doaj.org/article/44dd7434e145415db367f38b89d73bd6
Autor:
G. Raymond Lochhead, Dan L. Longo, Jeffrey M. Venstrom, Cordelia Dunai, William J. Murphy, Lam T. Khuat, Nicole Baumgarth, Claire Pomeroy, Juan Du, Ethan G. Aguilar, Bruce R. Blazar, Anthony E. Zamora, Can M. Sungur
Publikováno v:
JCI insight, vol 2, iss 10
Natural killer (NK) cells can be divided into phenotypic subsets based on expression of receptors that bind self-MHC-I molecules, a concept termed licensing or education. Here we show NK cell subsets with different migratory, effector, and immunoregu
Autor:
Can M. Sungur, William J. Murphy
Publikováno v:
Hematology. 2013:227-233
Natural killer (NK) cells represent a key component of innate immunity. The utility of mouse models to recapitulate the human immune response has been a matter of ongoing debate, especially with regard to NK cells. However, mouse models of NK cells h
Autor:
Maite Alvarez, Yajarayma J. Tang-Feldman, Can M. Sungur, William J. Murphy, Claire Pomeroy, Anthony E. Zamora
Publikováno v:
Blood. 122:1518-1521
Natural killer (NK) cells express inhibitory receptors with varied binding affinities to specific major histocompatibility complex class I (MHC-I) haplotypes. NK cells can be classified as licensed or unlicensed based on their ability or inability to
Autor:
Can M. Sungur, William J. Murphy, Stephen K. Anderson, Claire Pomeroy, Erik Ames, Maite Alvarez
Publikováno v:
The Journal of Immunology. 191:688-698
NK subsets have activating and inhibitory receptors that bind MHC-I. Ly49A is a mouse inhibitory receptor that binds with high affinity to H2d in both a cis- and trans-manner. Ly49A cis-associations limit trans-interactions with H2d-expressing target
Autor:
Claire Pomeroy, Yajarayma J. Tang-Feldman, Dan L. Longo, Erik Ames, Mingyi Chen, Maite Alvarez, Can M. Sungur, William J. Murphy
Publikováno v:
Proceedings of the National Academy of Sciences. 110:7401-7406
Natural killer (NK) cells show differential functionality based on their capability of binding to self-MHC consistent with licensing. Here we show in vivo confirmation of the physiologic effects of licensing with differential effects of NK subsets on
Autor:
William J. Murphy, Gail D. Sckisel, Kory A. Alderson, Dan L. Longo, Warren S. Alexander, Robert H. Wiltrout, Myriam N. Bouchlaka, Annie Mirsoian, Athena M. Soulika, Abhinav Reddy, Marka R. Crittenden, Brendan D. Curti, Erik Ames, Arta M. Monjazeb, Can M. Sungur, Danice E. C. Wilkins, Bruce R. Blazar
Publikováno v:
Immunity, vol 43, iss 2
Primary T cell activation involves the integration of three distinct signals delivered in sequence: (1) antigen recognition, (2) costimulation, and (3) cytokine-mediated differentiation and expansion. Strong immunostimulatory events such as immunothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dba70aba4aed62a4466ed28ecc2eab6
https://escholarship.org/uc/item/8px353d9
https://escholarship.org/uc/item/8px353d9
Autor:
Can M. Sungur, William J. Murphy
Publikováno v:
Critical reviews in oncogenesis, vol 19, iss 1-2
Our understanding of NK biology has expanded immensely since the initial discovery of natural killer cells in 1975. New studies have uncovered various levels of immune regulation both on and by unique subsets of NK cells, which go well beyond simple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385922d40966521ae76362dfbb55ca7f
https://escholarship.org/uc/item/77x9b003
https://escholarship.org/uc/item/77x9b003
Publikováno v:
ResearcherID
Natural killer (NK) cells are lymphocytes of the innate immune system and are classically associated with cytotoxic responses to both virally infected as well as neoplastic cells. Activation of NK cells to exhibit their cytotoxicity is dependent on s