Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Can Kayatekin"'
Autor:
Catherine Viel, Jennifer Clarke, Can Kayatekin, Amy M. Richards, Ming Sum R. Chiang, Hyejung Park, Bing Wang, Lamya S. Shihabuddin, S. Pablo Sardi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Mutations in GBA, the gene encoding the lysosomal enzyme glucocerebrosidase (GCase), represent the greatest genetic risk factor for developing synucleinopathies including Parkinson’s disease (PD). Additionally, PD patients harboring a muta
Externí odkaz:
https://doaj.org/article/c4a35b81ff05400cb0b27881077b5aa3
Autor:
Hongge Wang, Matthew D. Davison, Martin L. Kramer, Weiliang Qiu, Tatiana Gladysheva, Ruby M. S. Chiang, Can Kayatekin, David R. Nascene, Leyla A. Taghizadeh, Carina J. King, Erin E. Nolan, Ashish O. Gupta, Paul J. Orchard, Troy C. Lund
Publikováno v:
Cells, Vol 11, Iss 5, p 913 (2022)
Cerebral adrenoleukodystrophy (CALD) is a devastating, demyelinating neuroinflammatory manifestation found in up to 40% of young males with an inherited mutation in ABCD1, the causative gene in adrenoleukodystrophy. The search for biomarkers which co
Externí odkaz:
https://doaj.org/article/34ab98a4720e4380955e7beeeab603d2
Autor:
Peter Tsvetkov, Timothy J. Eisen, Sven U. Heinrich, Zarina Brune, Erinc Hallacli, Greg A. Newby, Can Kayatekin, David Pincus, Susan Lindquist
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108001- (2020)
Summary: The heat shock protein 90 (Hsp90) chaperone functions as a protein-folding buffer and plays a role promoting the evolution of new heritable traits. To better understand how Hsp90 can affect mRNA translation, we screen more than 1,600 factors
Externí odkaz:
https://doaj.org/article/7ac8c65540344e49a4c7c6c9a8211d69
Publikováno v:
Biomedicines, Vol 9, Iss 5, p 446 (2021)
Genetic, epidemiological and experimental evidence implicate lysosomal dysfunction in Parkinson’s disease (PD) and related synucleinopathies. Investigate several mouse models of lysosomal storage diseases (LSDs) and evaluate pathologies reminiscent
Externí odkaz:
https://doaj.org/article/b08a79065d3c4022bd1730d80b50eaff
Autor:
Teresa J Broering, Hongyan Wang, Naomi K Boatright, Yang Wang, Katherine Baptista, Gilda Shayan, Kerry A Garrity, Can Kayatekin, Daryl A Bosco, C Robert Matthews, Donna M Ambrosino, Zuoshang Xu, Gregory J Babcock
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61210 (2013)
Mutations in the gene encoding human SOD1 (hSOD1) can cause amyotrophic lateral sclerosis (ALS) yet the mechanism by which mutant SOD1 can induce ALS is not fully understood. There is currently no cure for ALS or treatment that significantly reduces
Externí odkaz:
https://doaj.org/article/d327649f499e4fa9bda858e4bcefd3f3
Autor:
Anna-Karin E Svensson, Osman Bilsel, Can Kayatekin, Jessica A Adefusika, Jill A Zitzewitz, C Robert Matthews
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10064 (2010)
Amino acid replacements at dozens of positions in the dimeric protein human, Cu,Zn superoxide dismutase (SOD1) can cause amyotrophic lateral sclerosis (ALS). Although it has long been hypothesized that these mutations might enhance the populations of
Externí odkaz:
https://doaj.org/article/cc9477ab90c740ac907c19e1b7202efd
Autor:
Lamya S. Shihabuddin, Amy M. Richards, S. Pablo Sardi, Hyejung Park, Can Kayatekin, Ming Sum R. Chiang, Catherine Viel, Jennifer A. Clarke, Bing Wang
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Mutations in GBA, the gene encoding the lysosomal enzyme glucocerebrosidase (GCase), represent the greatest genetic risk factor for developing synucleinopathies including Parkinson’s disease (PD). Additionally, PD patients harboring a mutant GBA al
Publikováno v:
Biomedicines
Volume 9
Issue 5
Biomedicines, Vol 9, Iss 446, p 446 (2021)
Volume 9
Issue 5
Biomedicines, Vol 9, Iss 446, p 446 (2021)
Genetic, epidemiological and experimental evidence implicate lysosomal dysfunction in Parkinson’s disease (PD) and related synucleinopathies. Investigate several mouse models of lysosomal storage diseases (LSDs) and evaluate pathologies reminiscent
Autor:
Srinivas Shankara, Stephen L. Madden, Erin Teeple, Khushboo Jindal, S. Pablo Sardi, Beril Kiragasi, Can Kayatekin, Siddharth Annaldasula, Dinesh Kumar, Ann Byrne, Klinger Kw, Lilly Chai, Mahdiar Sadeghi
Alpha-synuclein (SNCA) aggregates are pathological hallmarks of synucleinopathies, neurodegenerative disorders including Parkinson’s Disease (PD) and Lewy Body Dementia (LBD). Functional networks are not yet well-characterized for SNCA by CNS cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41970ad3c85a1d7016b02ad3fe246330
https://doi.org/10.1101/2020.06.05.137166
https://doi.org/10.1101/2020.06.05.137166
Publikováno v:
Biophys J
The folding reaction of a stable monomeric variant of Cu/Zn superoxide dismutase (mSOD1), an enzyme responsible for the conversion of superoxide free radicals into hydrogen peroxide and oxygen, is known to be among the slowest folding processes that