Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Camran V Parast"'
Autor:
Michele Ann Mctigue, Michael R Gehring, Chris Pinko, J. Ernest Villafranca, Chen-Chen Kan, Camran V Parast, Krzysztof Appelt, Richard E. Showalter, Barbara Mroczkowski, John A Wickersham, Anna Tempczyk-Russell
Publikováno v:
Structure. 7:319-330
Background: Angiogenesis is involved in tumor growth, macular degeneration, retinopathy and other diseases. Vascular endothelial growth factor (VEGF) stimulates angiogenesis by binding to specific receptors (VEGFRs) on the surface of vascular endothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cd0c114d6524dab68f410cf59cf22b
https://doi.org/10.1016/s0969-2126(99)80042-2
https://doi.org/10.1016/s0969-2126(99)80042-2
Publikováno v:
Biochemistry. 34:5712-5717
Pyruvate formate-lyase (PFL) is a glycyl radical-containing enzyme that catalyzes the reversible, nonoxidative conversion of pyruvate and CoA into acetyl-CoA and formate. The radical is located on the alpha-carbon of glycine 734 and is required for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291e160324fe407ecad8bc45c032b52e
https://doi.org/10.1021/bi00017a002
https://doi.org/10.1021/bi00017a002
Autor:
Sandra A. Lewisch, Kenny K. Wong, John W. Kozarich, Richard S. Magliozzo, Camran V. Parast, Jack Peisach
Publikováno v:
Biochemistry. 34:2393-2399
Pyruvate formate-lyase (PFL) catalyzes the reversible conversion of CoA and pyruvate into acetyl-CoA and formate. Active enzyme contains a glycyl radical whose alpha-hydrogen undergoes rapid exchange with solvent (t1/2 approximately 5 min at 0 degree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab617e460b7ac3f406d7c16d6c88de0
https://doi.org/10.1021/bi00008a001
https://doi.org/10.1021/bi00008a001
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 55:531-533
Under anaerobic conditions, the reaction catalysed by pyruvate formate-lyase (PFL) is the first reaction after the production of pyruvate in the glycolytic pathway. Crystallization trials with Escherichia coli PFL were unsuccessful and therefore limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed3d514541d5e27f82a13f1545d9bac
https://doi.org/10.1107/s0907444998011056
https://doi.org/10.1107/s0907444998011056
Autor:
Godrej Khambatta, Krzysztof Appelt, Shawn Misialek, Chris Pinko, Barbara Mroczkowski, Camran V. Parast
Publikováno v:
Biochemistry. 37(47)
Vascular endothelial growth factor (VEGF) is a dimeric protein which induces formation of new blood vessels (angiogenesis) through binding to VEGF-receptor-2 tyrosine kinase (VEGFR2 TK) or KDR (kinase insert domain-containing receptor) on the surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25b4a2c6c31fc2fa2a53025a1c885e8
https://pubmed.ncbi.nlm.nih.gov/9843450
https://pubmed.ncbi.nlm.nih.gov/9843450
Autor:
Jack Peisach, Richard S. Magliozzo, Kenny K. Wong, John W. Kozarich, Camran V. Parast, Sreelatha G. Reddy
Publikováno v:
Biochemistry. 37(2)
We here report EPR studies that provide evidence for radical intermediates generated from the glycyl radical of activated pyruvate formate-lyase (PFL) during the process of oxygen-dependent enzyme inactivation, radical quenching, and protein fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52dffcf37c05d58d800a29a05e701fe8
https://pubmed.ncbi.nlm.nih.gov/9425077
https://pubmed.ncbi.nlm.nih.gov/9425077
Publikováno v:
Journal of the American Chemical Society. 117:10601-10602
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::760ddf5138d81adc9e2a8909252d48e0
https://doi.org/10.1021/ja00147a034
https://doi.org/10.1021/ja00147a034