P334: CHARACTERIZATION OF A DUX4‐R INHIBITOR AS A POSSIBLE TREATMENT FOR ACUTE LYMPHOBLASTIC LEUKEMIA.

Autor: Mara, S., Runfola, V., Pannese, M., Caronni, C., Giambruno, R., Campolungo, D., Ghirardi, C., Gabellini, D.

Publikováno v: HemaSphere; 2022 Supplement 3, Vol. 6, p234-235, 2p

A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis

Autor: Alex Pezzotta, Anna Pistocchi, Patrick Mehlen, Andrea Paradisi, Anna Di Matteo, Federico Forneris, Daniele Campolungo, Costanza Giampietro, Elisa Belloni, Gianluca Deflorian, Nina Volf, Antonella Chiapparino, Michael Rehman, William Vermi, Maria Paola Paronetto, Mattia Bugatti, Davide Pradella, Claudia Ghigna, Anne Eichmann, Matteo Campioni, Serena Zacchigna, Luigi Scietti

Publikováno v: Nature Communications
Nature Communications, 2021, 12 (1), pp.4872. ⟨10.1038/s41467-021-24998-6⟩
Nature Communications, 12
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4872. ⟨10.1038/s41467-021-24998-6⟩

The Netrin-1 receptor UNC5B is an axon guidance regulator that is also expressed in endothelial cells (ECs), where it finely controls developmental and tumor angiogenesis. In the absence of Netrin-1, UNC5B induces apoptosis that is blocked upon Netri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b474c65ef53add8d7c9ee805789f290
https://doi.org/10.1038/s41467-021-24998-6