Using available in vitro metabolite identification and time course kinetics for β-chloroprene and its metabolite, (1-chloroethenyl) oxirane, to include reactive oxidative metabolites and glutathione depletion in a PBPK model for β-chloroprene.

Autor: Campbell Jr., J. L., Clewell III, H. J., Van Landingham, C., Gentry, P. R., Andersen, M. E.

Publikováno v: Frontiers in Pharmacology; 2023, p1-13, 13p

Reducing uncertainty in dose-response assessments by incorporating Bayesian benchmark dose modeling and in vitro data on population variability.

Autor: Lu EH; Interdisciplinary Faculty of Toxicology and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas, USA., Ford LC; Interdisciplinary Faculty of Toxicology and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas, USA., Rusyn I; Interdisciplinary Faculty of Toxicology and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas, USA., Chiu WA; Interdisciplinary Faculty of Toxicology and Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas, USA.

Publikováno v: Risk analysis : an official publication of the Society for Risk Analysis [Risk Anal] 2024 Aug 16. Date of Electronic Publication: 2024 Aug 16.

Predicting the Transfer of Contaminants in Ruminants by Models – Potentials and Challenges.

Autor: Klevenhusen, Fenja, Südekum, Karl-Heinz, Breves, Gerhard, Kolrep, Franziska, Kietzmann, Manfred, Gerletti, Pietro, Numata, Jorge, Spolders, Markus, Pieper, Robert, Kowalczyk, Janine

Publikováno v: Altex; 2021, Vol. 38 Issue 3, p398-418, 21p

MEHP interferes with mitochondrial functions and homeostasis in skeletal muscle cells.

Autor: Yi-Huan Chen, Yi-Ju Wu, Wei-Cheng Chen, Tzong-Shyuan Lee, Tsui-Chun Tsou, Hsuan-Chia Chang, Sheng-Wen Lo, Shen-Liang Chen

Publikováno v: Bioscience Reports; Apr2020, Vol. 40 Issue 4, p1-14, 14p

Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) contamination from textiles.

Autor: Supreeyasunthorn, Phenpimuk, Boontanon, Suwanna K., Boontanon, Narin

Publikováno v: Journal of Environmental Science & Health. Part A. Toxic/Hazardous Substances & Environmental Engineering; 2016, Vol. 51 Issue 6, p472-477, 6p