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Loss of SPEG Inhibitory Phosphorylation of RyR2 Promotes Atrial Fibrillation

Autor: Campbell, Hannah M, Quick, Ann P, Abu-Taha, Issam, Chiang, David Y, Kramm, Carlos F, Word, Tarah A, Brandenburg, Sören, Hulsurkar, Mohit, Alsina, Katherina M, Liu, Hui-Bin, Martin, Brian, Uhlenkamp, Dennis, Moore, Oliver M, Lahiri, Satadru K, Corradini, Eleonora, Kamler, Markus, Heck, Albert J R, Lehnart, Stephan E, Dobrev, Dobromir, Wehrens, Xander H T, Sub Biomol.Mass Spectrometry & Proteom., Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics

Publikováno v: Circulation, 142(12). Lippincott Williams and Wilkins

Background: Enhanced diastolic calcium (Ca2+) release via ryanodine receptor type-2 (RyR2) has been implicated in atrial fibrillation (AF) promotion. Diastolic sarcoplasmic reticulum (SR) Ca2+ leak is caused by increased RyR2 phosphorylation by prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::091eb3d0fed39ed9f6cb75d3d5e5cdf6
https://dspace.library.uu.nl/handle/1874/408575

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Class I PI3K Biology.

Autor: Aytenfisu TY; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA., Campbell HM; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA., Chakrabarti M; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA., Amzel LM; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA., Gabelli SB; Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA. gabelli@jhmi.edu.; Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. gabelli@jhmi.edu.; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. gabelli@jhmi.edu.

Publikováno v: Current topics in microbiology and immunology [Curr Top Microbiol Immunol] 2022; Vol. 436, pp. 3-49.