GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment.

Autor: Nuermberger EL; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA., Martínez-Martínez MS; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Sanz O; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Urones B; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Esquivias J; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Soni H; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA., Tasneen R; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA., Tyagi S; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA., Li SY; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA., Converse PJ; Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35 School of Medicine, Baltimore, Maryland, USA., Boshoff HI; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Robertson GT; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA., Besra GS; Institute of Microbiology and Infection, School of Biosciences, University of Birminghamgrid.6572.6, Birmingham, United Kingdom., Abrahams KA; Institute of Microbiology and Infection, School of Biosciences, University of Birminghamgrid.6572.6, Birmingham, United Kingdom., Upton AM; TB Alliance: Global Alliance for Tuberculosis Drug Development, New York, New York, USA., Mdluli K; TB Alliance: Global Alliance for Tuberculosis Drug Development, New York, New York, USA., Boyle GW; GSK: Research, GlaxoSmithKline R&D, Ware, United Kingdom., Turner S; GSK: Research, GlaxoSmithKline R&D, Ware, United Kingdom., Fotouhi N; TB Alliance: Global Alliance for Tuberculosis Drug Development, New York, New York, USA., Cammack NC; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Siles JM; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Alonso M; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Escribano J; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Lelievre J; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Rullas-Trincado J; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Pérez-Herrán E; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Bates RH; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Maher-Edwards G; GSK, Brentford, Middlesex, United Kingdom., Barros D; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Ballell L; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain., Jiménez E; Diseases of the Developing World, GlaxoSmithKline R+D Limited, Tres Cantos, Madrid, Spain.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2022 Jun 21; Vol. 66 (6), pp. e0013222. Date of Electronic Publication: 2022 May 24.

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria.

Autor: Cox JA; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Abrahams KA; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Alemparte C; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Ghidelli-Disse S; Cellzome, Meyerhofstrasse 1, Heidelberg 69117, Germany., Rullas J; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Angulo-Barturen I; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Singh A; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Gurcha SS; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Nataraj V; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Bethell S; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Remuiñán MJ; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Encinas L; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Jervis PJ; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Cammack NC; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Bhatt A; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Kruse U; Cellzome, Meyerhofstrasse 1, Heidelberg 69117, Germany., Bantscheff M; Cellzome, Meyerhofstrasse 1, Heidelberg 69117, Germany., Fütterer K; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Barros D; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Ballell L; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Drewes G; Cellzome, Meyerhofstrasse 1, Heidelberg 69117, Germany., Besra GS; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Publikováno v: Nature microbiology [Nat Microbiol] 2016 Jan 18; Vol. 1, pp. 15006. Date of Electronic Publication: 2016 Jan 18.