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Akademický článek

Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer

Autor: Yulun Wu, Chaoran Jia, Wei Liu, Wei Zhan, Yao Chen, Junlin Lu, Yongli Bao, Shuyue Wang, Chunlei Yu, Lihua Zheng, Luguo Sun, Zhenbo Song

Publikováno v: Journal of Advanced Research, Vol 65, Iss , Pp 89-104 (2024)

Introduction: Ovarian cancer (OC) is known for its high mortality rate. Although sodium citrate has anti-tumor effects in various cancers, its effect and mechanism in OC remain unclear. Objectives: To analyze the inhibitory effect of sodium citrate o

Externí odkaz: https://doaj.org/article/6cdc93763df64dc78868fb87319d5662

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Akademický článek

CAMKK2-AMPK axis endows dietary calcium and phosphorus levels with regulatory effects on lipid metabolism in weaned piglets

Autor: Zhenyan Miao, Yanjie Sun, Zhangjian Feng, Qiwen Wu, Xuefen Yang, Li Wang, Zongyong Jiang, Ying Li, Hongbo Yi

Publikováno v: Journal of Animal Science and Biotechnology, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract Background In the realm of swine production, optimizing body composition and reducing excessive fat accumulation is critical for enhancing both economic efficiency and meat quality. Despite the acknowledged impact of dietary calcium (Ca) and

Externí odkaz: https://doaj.org/article/cfca6d3780dd45b6ae06b96539a8d679

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Akademický článek

β-Hydroxybutyrate Protects Against Cisplatin-Induced Renal Damage via Regulating Ferroptosis

Autor: Ruixue Tian, Shuqin Tang, Jingyu Zhao, Yajie Hao, Limei Zhao, Xiutao Han, Xingru Wang, Lijun Zhang, Rongshan Li, Xiaoshuang Zhou

Publikováno v: Renal Failure, Vol 46, Iss 1 (2024)

Cisplatin is a particularly potent antineoplastic drug. However, its usefulness is restricted due to the induction of nephrotoxicity. More recent research has indicated that β-hydroxybutyrate (β-HB) protects against acute or chronic organ damage as

Externí odkaz: https://doaj.org/article/43438698fc474643a9cbe4e9d4b17d7a

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Cytotoxic effects of the cigarette smoke extract of heated tobacco products on human oral squamous cell carcinoma: the role of reactive oxygen species and CaMKK2

Autor: Nagao Kagemichi, Masanari Umemura, Soichiro Ishikawa, Yu Iida, Shota Takayasu, Akane Nagasako, Rina Nakakaji, Taisuke Akimoto, Makoto Ohtake, Takahiro Horinouchi, Tetsuya Yamamoto, Yoshihiro Ishikawa

Publikováno v: Journal of Physiological Sciences, Vol 74, Iss 1, Pp 1-15 (2024)

Abstract Background The increasing prevalence of heated tobacco products (HTPs) has heightened concerns regarding their potential health risks. Previous studies have demonstrated the toxicity of cigarette smoke extract (CSE) from traditional tobacco�

Externí odkaz: https://doaj.org/article/2c28348936374798a14441e90d65641d

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Akademický článek

Methyl Cinnamate (MC) Alleviates Free Fatty Acids (FFAs) Induced Lipid Accumulation Through the AMPK Pathway in HepG2 Cells

Autor: Fu Y, Li G, Feng Z, Liu J, Wang X, Wang T

Publikováno v: Diabetes, Metabolic Syndrome and Obesity, Vol Volume 17, Pp 1183-1197 (2024)

Yingda Fu,1 Guangbing Li,1,2 Zichen Feng,1 Jun Liu,2 Xiaoyu Wang,1 Tao Wang,2 Jun Liu1,2 1Department of Hepatobiliary Surgery and Center of Organ Transplantation, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan,

Externí odkaz: https://doaj.org/article/74b086e7e6a14570b5f6af8eefd7df13

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Bufalin targeting CAMKK2 inhibits the occurrence and development of intrahepatic cholangiocarcinoma through Wnt/β-catenin signal pathway

Autor: Huhu Zhang, Xiaolei Dong, Xiaoyan Ding, Guoxiang Liu, Fanghao Yang, Qinghang Song, Hongxiao Sun, Guang Chen, Shuang Li, Ya Li, Mengjun Wang, Tingting Guo, Zhe Zhang, Bing Li, Lina Yang

Publikováno v: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-20 (2023)

Abstract Background Intrahepatic cholangiocarcinoma (ICC) accounts for about 15% of primary liver cancer, and the incidence rate has been rising in recent years. Surgical resection is the best treatment for ICC, but the 5-year survival rate is less t

Externí odkaz: https://doaj.org/article/d313d81c69a8459eb984c18d226318bc

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Whole-exome sequencing combined with postoperative data identify c.1614dup (CAMKK2) as a novel candidate monogenic obesity variant

Autor: Yan Wang, Chao Yang, Jun Wen, Lingling Ju, Zhengyun Ren, Tongtong Zhang, Yanjun Liu

Publikováno v: Frontiers in Endocrinology, Vol 15 (2024)

Early-onset obesity is a rising health concern influenced by heredity. However, many monogenic obesity variants (MOVs) remain to be discovered due to differences in ethnicity and culture. Additionally, patients with known MOVs have shown limited weig

Externí odkaz: https://doaj.org/article/601bb934b0e44ef5827f33b4c5b67688

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