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Analysis of the antigenic determinants of the OspC protein of the Lyme disease spirochetes: Evidence that the C10 motif is not immunodominant or required to elicit bactericidal antibody responses.

Autor: Izac JR; Dept. Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0678, USA; Division of Immunology, Tulane National Primate Research Center, Covington, LA 70433, USA; Department of Large Animal Clinical Sciences, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA; Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA., Camire AC; Dept. Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0678, USA; Division of Immunology, Tulane National Primate Research Center, Covington, LA 70433, USA; Department of Large Animal Clinical Sciences, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA; Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA., Earnhart CG; Dept. Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0678, USA; Division of Immunology, Tulane National Primate Research Center, Covington, LA 70433, USA; Department of Large Animal Clinical Sciences, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA; Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA., Embers ME; Dept. Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0678, USA; Division of Immunology, Tulane National Primate Research Center, Covington, LA 70433, USA; Department of Large Animal Clinical Sciences, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA; Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA., Funk RA; Dept. Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0678, USA; Division of Immunology, Tulane National Primate Research Center, Covington, LA 70433, USA; Department of Large Animal Clinical Sciences, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA; Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA., Breitschwerdt EB; Dept. Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0678, USA; Division of Immunology, Tulane National Primate Research Center, Covington, LA 70433, USA; Department of Large Animal Clinical Sciences, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA; Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA., Marconi RT; Dept. Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0678, USA; Division of Immunology, Tulane National Primate Research Center, Covington, LA 70433, USA; Department of Large Animal Clinical Sciences, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA; Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA. Electronic address: Richard.marconi@vcuhealth.org.

Publikováno v: Vaccine [Vaccine] 2019 Apr 17; Vol. 37 (17), pp. 2401-2407. Date of Electronic Publication: 2019 Mar 25.