Zobrazeno 1 - 10 of 50 pro vyhledávání: '"Camilo Henrique da Silva Lima"'
1
Akademický článek
Py-CoMFA, docking, and molecular dynamics simulations of Leishmania (L.) amazonensis arginase inhibitors
Autor: Priscila Goes Camargo, Carine Ribeiro dos Santos, Magaly Girão Albuquerque, Carlos Rangel Rodrigues, Camilo Henrique da Silva Lima
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-23 (2024)
Abstract Leishmaniasis is a disease caused by a protozoan of the genus Leishmania, affecting millions of people, mainly in tropical countries, due to poor social conditions and low economic development. First-line chemotherapeutic agents involve high
Externí odkaz: https://doaj.org/article/978454de952c42ce9c0cc57dc144c2bb
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2
Akademický článek
Molecular modelling studies and in vitro enzymatic assays identified A 4-(nitrobenzyl)guanidine derivative as inhibitor of SARS-CoV-2 Mpro
Autor: Kaio Maciel de Santiago-Silva, Priscila Goes Camargo, Larissa Esteves Carvalho Constant, Stephany da Silva Costa, Giovanna Barbosa Frensel, Diego Allonso, Gerson Nakazato, Camilo Henrique da Silva Lima, Marcelle de Lima Ferreira Bispo
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Scientists and researchers have been searching for drugs targeting the main protease (Mpro) of SARS-CoV-2, which is crucial for virus replication. This study employed a virtual screening based on molecular docking to identify benzoylguanidin
Externí odkaz: https://doaj.org/article/ce15e21da1944d63a519ca082f6675a0
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3
Akademický článek
Antileishmanial Activity of 4,8-Dimethoxynaphthalenyl Chalcones on Leishmania amazonensis
Autor: Kaio Maciel de Santiago-Silva, Bruna Taciane da Silva Bortoleti, Laudicéa do Nascimento Oliveira, Fernanda Lima de Azevedo Maia, Joyce Cristina Castro, Ivete Conchon Costa, Danielle Bidóia Lazarin, James L. Wardell, Solange M. S. V. Wardell, Magaly Girão Albuquerque, Camilo Henrique da Silva Lima, Wander Rogério Pavanelli, Marcelle de Lima Ferreira Bispo, Raoni Schroeder B. Gonçalves
Publikováno v: Antibiotics, Vol 11, Iss 10, p 1402 (2022)
Leishmaniasis is a neglected tropical disease caused by Leishmania species. Available therapeutic options have several limitations. The drive to develop new, more potent, and selective antileishmanial agents is thus a major goal. Herein we report the
Externí odkaz: https://doaj.org/article/59bfd238fa0f49c19af2afc8b76a5b47
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4
Molecular targets for chalcones in antileishmanial drug discovery
Autor: Marcelle de Lima Ferreira Bispo, Kaio Maciel de Santiago-Silva, Gabriel Felix da Silva Gomes, Carla Cristina Perez, Camilo Henrique da Silva Lima
Publikováno v: Mini-Reviews in Medicinal Chemistry. 23
Abstract: Leishmaniases are infectious diseases caused by flagellated protozoan parasites belonging to the genus Leishmania that infect cells of the mononuclear phagocytic system. These parasites are transmitted to humans by biting an infected female
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51bb4debf59a01ed6b5db365375221ce
https://doi.org/10.2174/1389557523666230127125058
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8
Thiohydantoins and hydantoins derived from amino acids as potent urease inhibitors: Inhibitory activity and ligand-target interactions
Autor: Priscila Goes Camargo, Marciéli Fabris, Matheus Yoshimitsu Tatsuta Nakamae, Breno Germano de Freitas Oliveira, Camilo Henrique da Silva Lima, Ângelo de Fátima, Marcelle de Lima Ferreira Bispo, Fernando Macedo
Publikováno v: Chemico-biological interactions. 365
We report the investigation of hydantoins and thiohydantoins derived from L and d-amino acids as inhibitors against the Canavalia ensiformis urease (CEU). The biochemical in vitro assay against CEU revealed a promising inhibitory potential for most t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba62c00b523cae40cdf53a7665a48de
https://pubmed.ncbi.nlm.nih.gov/35853540
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9
Development of parameters compatible with the CHARMM36 force field for [Fe4S4]2+ clusters and molecular dynamics simulations of adenosine-5’-phosphosulfate reductase in GROMACS 2019
Autor: Karina de Carvalho Pougy, Talis Uelisson da Silva, Sergio Machado, Camilo Henrique da Silva Lima, Magaly Girão Albuquerque
Publikováno v: Journal of Biomolecular Structure and Dynamics. 40:3481-3491
DFT calculations were used to obtain parameters compatible with the CHARMM36 force field for iron-sulfur clusters (Fe-S) of the type [Fe4S4]2+ that are coordinated to dissimilatory adenosine-5’-phosphosulfate reductase (APSrAB). Classical molecular
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11bc3b15934cab0faaef96b0fd7fa002
https://doi.org/10.1080/07391102.2020.1847687
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