A multiparametric niche-like drug screening platform in acute myeloid leukemia

Autor: Reinaldo Dal Bello, Justine Pasanisi, Romane Joudinaud, Matthieu Duchmann, Bryann Pardieu, Paolo Ayaka, Giuseppe Di Feo, Gaetano Sodaro, Clémentine Chauvel, Rathana Kim, Loic Vasseur, Laureen Chat, Frank Ling, Kim Pacchiardi, Camille Vaganay, Jeannig Berrou, Chaima Benaksas, Nicolas Boissel, Thorsten Braun, Claude Preudhomme, Hervé Dombret, Emmanuel Raffoux, Nina Fenouille, Emmanuelle Clappier, Lionel Adès, Alexandre Puissant, Raphael Itzykson

Publikováno v: Blood Cancer Journal, Vol 12, Iss 6, Pp 1-12 (2022)

Abstract Functional precision medicine in AML often relies on short-term in vitro drug sensitivity screening (DSS) of primary patient cells in standard culture conditions. We designed a niche-like DSS assay combining physiologic hypoxia (O2 3%) and m

Externí odkaz: https://doaj.org/article/e6d2ce98e5c74712a309d64d267db6b8

Figure S9 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Autor: Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, Angela Su

Effect of MTHFR impairment on response to OTX015.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74df922357521a0f49b6f8a57bd45e18
https://doi.org/10.1158/2159-8290.22535093

Data from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Autor: Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, Angela Su

Deciphering the impact of metabolic intervention on response to anticancer therapy may elucidate a path toward improved clinical responses. Here, we identify amino acid–related pathways connected to the folate cycle whose activation predicts sensit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78e2ca8829ad86675f7cab2d71d11273
https://doi.org/10.1158/2159-8290.c.6547754.v1

Tumor Lysis Syndrome and AKI: Beyond Crystal Mechanisms

Autor: Marine Arnaud, Maud Loiselle, Camille Vaganay, Stéphanie Pons, Emmanuel Letavernier, Jordane Demonchy, Sofiane Fodil, Manal Nouacer, Sandrine Placier, Perrine Frère, Eden Arrii, Julien Lion, Nuala Mooney, Raphael Itzykson, Chakib Djediat, Alexandre Puissant, Lara Zafrani

Publikováno v: J Am Soc Nephrol
Journal of the American Society of Nephrology
Journal of the American Society of Nephrology, 2022, 33 (6), pp.1154-1171. ⟨10.1681/ASN.2021070997⟩

International audience; Background The pathophysiology of AKI during tumor lysis syndrome (TLS) is not well understood due to the paucity of data. We aimed to decipher crystal-dependent and crystal-independent mechanisms of TLS-induced AKI. Methods C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956c2f0215aff90122fe8d399c0aed9d
https://europepmc.org/articles/PMC9161807/

Screening of ETO2-GLIS2-induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia

Autor: Salima Benbarche, Cécile K. Lopez, Eralda Salataj, Zakia Aid, Cécile Thirant, Marie-Charlotte Laiguillon, Séverine Lecourt, Yannis Belloucif, Camille Vaganay, Marion Antonini, Jiang Hu, Alexandra da Silva Babinet, Delphine Ndiaye-Lobry, Bryann Pardieu, Arnaud Petit, Alexandre Puissant, Julie Chaumeil, Thomas Mercher, Camille Lobry

Publikováno v: Science advances. 8(6)

Super Enhancers (SEs) are clusters of regulatory elements associated with cell identity and disease. However, whether these elements are induced by oncogenes and can regulate gene modules cooperating for cancer cell transformation or maintenance rema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba62397dd475f05f4a65fbf2e630ab50
https://pubmed.ncbi.nlm.nih.gov/35138899