Preclinical Studies Identify Non-Apoptotic Low-Level Caspase-3 as Therapeutic Target in Pemphigus Vulgaris

Autor: Beyza S. Sayar, Katja Schulze, Denise Howald, Camille Luyet, Eliane J. Müller, Arnaud Galichet

Publikováno v: PLOS ONE
PLoS ONE, Vol 10, Iss 3, p e0119809 (2015)
Luyet, Camille; Schulze, Katja; Sayar, Beyza; Howald, Denise; Müller, Eliane Jasmine; Arnaud, Galichet (2015). Preclinical studies identify non-apoptotic low-level caspase-3 as therapeutic target in pemphigus vulgaris. PLoS ONE, 10(3), e0119809. Public Library of Science 10.1371/journal.pone.0119809
PLoS ONE

The majority of pemphigus vulgaris (PV) patients suffer from a live-threatening loss of intercellular adhesion between keratinocytes (acantholysis). The disease is caused by auto-antibodies that bind to desmosomal cadherins desmoglein (Dsg) 3 or Dsg3

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https://doi.org/10.1371/journal.pone.0119809