Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Camille Le Chapelain"'
Autor:
Johannes Büchler, Sumire Honda Malca, David Patsch, Moritz Voss, Nicholas J. Turner, Uwe T. Bornscheuer, Oliver Allemann, Camille Le Chapelain, Alexandre Lumbroso, Olivier Loiseleur, Rebecca Buller
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The late-stage functionalization of unactivated carbon–hydrogen bonds is a difficult but important task, which has been met with promising but limited success through synthetic organic chemistry. Here the authors use machine learning to engineer We
Externí odkaz:
https://doaj.org/article/b0080e192c1f4807837af8d63df4a6df
Autor:
Johannes Büchler, Eimear Hegarty, Kirsten Schroer, Radka Snajdrova, Nicholas J. Turner, Olivier Loiseleur, Rebecca Buller, Camille Le Chapelain
Publikováno v:
Helvetica Chimica Acta. 106
In 2017, two companies, Novartis AG and Syngenta AG, joined forces with the group of Prof. Buller, head of the Competence Center for Biocatalysis (CCBIO), to tackle the challenge of enzymatic late-stage halogenation. This biocatalytic method was cons
Autor:
Marcel Kaiser, Lei Zhao, Alexander O. Brachmann, Helge B. Bode, Michael Groll, Camille Le Chapelain
Publikováno v:
ChemBioChem
Chembiochem
Chembiochem
The glidobactin‐like natural products (GLNPs) glidobactin A and cepafungin I have been reported to be potent proteasome inhibitors and are regarded as promising candidates for anticancer drug development. Their biosynthetic gene cluster (BGC) plu18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7258fdc156436394e0883eb52dde68
https://mediatum.ub.tum.de/doc/1624364/document.pdf
https://mediatum.ub.tum.de/doc/1624364/document.pdf
Autor:
Alexander O. Brachmann, Marcel Kaiser, Lei Zhao, Helge B. Bode, Michael Groll, Camille Le Chapelain
Publikováno v:
ChemBioChem. 22:1494-1494
Autor:
Eva M. Huber, Michael Groll, Haissi Cui, Regina Baur, Camille Le Chapelain, Christian Dubiella, Wolfgang Heinemeyer
Publikováno v:
ChemBioChem. 18:523-526
Selective inhibition of the immunoproteasome is a promising approach towards the development of immunomodulatory drugs. Recently, a class of substituted thiazole compounds that combine a non-peptidic scaffold with the absence of an electrophile has b
Publikováno v:
Organic Letters. 17:5602-5605
This study documents that chlorinated analogs of leukotoxin diol 1, in which the vic-diol has been replaced with vic-chlorides (2), induce caspase 3 activity and apoptosis on HepG2 cells in a dose-dependent manner in analogy to the parent diol. This
Autor:
Camille Le Chapelain, Michael Groll
Publikováno v:
Angewandte Chemie International Edition. 55:6370-6372
One life, two strategies: Crucial structural differences between the human and the Plasmodium falciparum proteasomes were recently identified. A combination of cryo-EM and functional characterization enabled the design of a selective antimalarial pro
Autor:
Camille Le Chapelain, Michael Groll
Publikováno v:
Angewandte Chemie. 128:6478-6480
Autor:
Camille Le Chapelain
Publikováno v:
Organic & Biomolecular Chemistry, 15 (29)
Herein is described a convergent enantioselective route to an advanced intermediate in the synthesis of schiglautone A, a Schisandra triterpenoid with an unusual architecture. The synthetic route to this intermediate displaying 6 of the 7 stereocente
Autor:
Evelyne Joliat, Adelbert Bacher, Boris Illarionov, Anna K. H. Hirsch, Camille Le Chapelain, W. Bernd Schweizer, François Diederich, Noah Munzinger, Paolo Mombelli, Markus Fischer
Publikováno v:
European Journal of Organic Chemistry. 2013:1068-1079
The enzymes of the mevalonate-independent biosynthetic pathway to isoprenoids are attractive targets for the development of new drug candidates, in particular against malaria and tuberculosis, because they are present in major human pathogens but not