Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Camille Keeler"'
Autor:
James W. Murphy, Deepa Rajasekaran, Janie Merkel, Erin Skeens, Camille Keeler, Michael E. Hodsdon, George P. Lisi, Elias Lolis
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
CXCL12 activates CXCR4 and is involved in embryogenesis, hematopoiesis, and angiogenesis. It has pathological roles in HIV-1, WHIM disease, cancer, and autoimmune diseases. An antagonist, AMD3100, is used for the release of CD34+ hematopoietic stem c
Externí odkaz:
https://doaj.org/article/40fb3af75ca148da8d1fef2ed5c15c09
Autor:
William S. Nelligan, Alison L. O'Neil, Andrea Roberts, T. David Westmoreland, Rachael Barlow, Camille Keeler
Publikováno v:
Journal of Chemical Education. 98:143-149
Developing a broadly based positive culture of safety in undergraduate instructional laboratory settings remains a significant challenge for chemical educators. An enhanced safety component has been developed for an upper-level laboratory course base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e8971d6b6b2c903002ee3d4ee39e928
https://doi.org/10.1021/acs.jchemed.0c00118
https://doi.org/10.1021/acs.jchemed.0c00118
Autor:
Janus Vang, Yulia Pustovalova, Dmitry M. Korzhnev, Oksana Gorbatyuk, Camille Keeler, Michael E. Hodsdon, Jeffrey C. Hoch
Publikováno v:
Biophys J
Metal binding by members of the growth hormone (GH) family of hematopoietic cytokines has been a subject of considerable interest. However, beyond appreciation of its role in reversible packing of GH proteins in secretory granules, the molecular mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c18373135b7292e51741b302018292
https://pubmed.ncbi.nlm.nih.gov/35192840
https://pubmed.ncbi.nlm.nih.gov/35192840
Autor:
Ivana Y. Kuo, Camille Keeler, Barbara E. Ehrlich, Elias Lolis, Michael E. Hodsdon, Yifei Yang
Publikováno v:
The Journal of Biological Chemistry
Background: The C-terminal tail of polycystin-2 (PC2 Cterm) is essential for channel assembly and regulation. Results: Both human and sea urchin PC2 Cterm form trimers and contain EF-hand domains that bind to Ca2+. Conclusion: Oligomerization affects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517bcc855fd0f9fcf204f61afaf6b54b
http://europepmc.org/articles/PMC4400361
http://europepmc.org/articles/PMC4400361
Autor:
Joachim M. Vinther, Michael E. Hodsdon, Jens J. Led, Camille Keeler, Sebastian Meier, Malene Ringkjøbing Jensen, Henrik Gesmar, Helle Johansson
Publikováno v:
Journal of the American Chemical Society
Weak and transient protein-protein interactions underlie numerous biological processes. However, the location of the interaction sites of the specific complexes and the effect of transient, nonspecific protein-protein interactions often remain elusiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a516bc3295d43be1a80ca1ab08bf5ff
https://doi.org/10.1021/ja503546j
https://doi.org/10.1021/ja503546j
Autor:
Edward T. Petri, Camille Keeler, Rachel Corbin, Ivana Y. Kuo, Andjelka S. Ćelić, Barbara E. Ehrlich, Michael E. Hodsdon
Publikováno v:
The FASEB Journal. 28:2332-2346
Polycystin 2 (PC2) is a calcium-dependent calcium channel, and mutations to human PC2 (hPC2) are associated with polycystic kidney disease. The C-terminal tail of hPC2 contains 2 EF hand motifs, but only the second binds calcium. Here, we investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd363545832320b555954f45f927f45e
https://doi.org/10.1096/fj.13-247106
https://doi.org/10.1096/fj.13-247106
Autor:
Barbara E. Ehrlich, Michael E. Hodsdon, Chengpeng Fan, Camille Keeler, Jennifer H. Benbow, Brenda DeGray, Elias Lolis, Taylor Mann
Publikováno v:
Journal of Biological Chemistry. 287:37907-37916
Peripheral neuropathy is one of the most severe and irreversible side effects caused by treatment from several chemotherapeutic drugs, including paclitaxel (Taxol®) and vincristine. Strategies are needed that inhibit this unwanted side effect withou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8399ab6cda68a2db0ce8691273542fb
https://doi.org/10.1074/jbc.m112.385070
https://doi.org/10.1074/jbc.m112.385070
Publikováno v:
Biochemistry. 51:7506-7514
Regulation of cellular processes by dietary nutrients is known to affect the likelihood of cancer development. One class of cancer-preventive nutrients, isothiocyanates (ITCs), derived from the consumption of cruciferous vegetables, is known to have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3849a8207b111fa6683001332c64021
https://doi.org/10.1021/bi3005494
https://doi.org/10.1021/bi3005494
Autor:
Dianqing Wu, Michael E. Hodsdon, Camille Keeler, Matthew Jones, Mansoor Ali Syed, Vineet Bhandari, Elias Lolis, Jeffrey K. Harrison, Deepa Rajasekaran
Publikováno v:
Biochemistry. 51:5642-5654
MIP-2/CXCL2 is a murine chemokine related to human chemokines that possesses the Glu-Leu-Arg (ELR) activation motif and activates CXCR2 for neutrophil chemotaxis. We determined the structure of MIP-2 to 1.9 Å resolution and created a model with its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c067574bf45716b266601af30ab97975
https://doi.org/10.1021/bi3001566
https://doi.org/10.1021/bi3001566
Publikováno v:
Protein Science. 18:909-920
A member of the family of hematopoietic cytokines human prolactin (hPRL) is a 23k kDa polypeptide hormone, which displays pH dependence in its structural and functional properties. The binding affinity of hPRL for the extracellular domain of its rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b38a216c57afb28959533ceadb7732
https://doi.org/10.1002/pro.100
https://doi.org/10.1002/pro.100