Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Camille Georges Wermuth"'
The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, thi
Publikováno v:
Synlett. 2006:3185-3204
This Account focuses on the palladium-catalysed cross-coupling reactions of pyridazines. The pyridazine moiety is of significant importance in the pharmaceutical as well as the agrochemical field. Synthetic transformations on this moiety, to yield se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::252ff5667a71a283706e34310a110b35
https://doi.org/10.1055/s-2006-951528
https://doi.org/10.1055/s-2006-951528
Publikováno v:
Chemical and Pharmaceutical Bulletin. 50:636-639
Obesity is a common disorder in the industrialized world. The major environmental factor associated with the rising prevalence of obesity is an increasingly sedentary lifestyle, compounded by greater levels of caloric intake. Recent studies 1—12) h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2abbaf47d0d44e806ec2d342df158a71
https://doi.org/10.1248/cpb.50.636
https://doi.org/10.1248/cpb.50.636
Autor:
Mathias Domostoj, André Mann, Camille-Georges Wermuth, Jean Suffert, Karin Briner, Christophe Morice
Publikováno v:
Tetrahedron Letters. 42:6499-6502
Two intramolecular routes were experimented to reach the hexahydrobenzofuro(2,3-c)pyridine platform: a Heck and a radical reaction. The radical route was applicable to all substrates, whereas the Heck route was of limited use. The key adducts were ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91358bfa57effdb52da433f8451c3e33
https://doi.org/10.1016/s0040-4039(01)01191-1
https://doi.org/10.1016/s0040-4039(01)01191-1
Publikováno v:
Journal of Molecular Modeling. 6:637-647
The binding mode of 3-aminopyridazine analogues to the M1 muscarinic receptor has been studied by two complementary modeling strategies: the ”active analog” approach and direct docking into a 3D model of the receptor. Modeling combined with SAR s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e712449afbf597a59302087cf715ec19
https://doi.org/10.1007/s0089400060637
https://doi.org/10.1007/s0089400060637
Autor:
Camille-Georges Wermuth
Publikováno v:
Journal of Heterocyclic Chemistry. 35:1091-1100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31f5c99b3f48e2ab8d8040e105fb2a08
https://doi.org/10.1002/jhet.5570350508
https://doi.org/10.1002/jhet.5570350508
Autor:
Marcel Hibert, Camille-Georges Wermuth, Susanne Trumpp-Kallmeyer, Herman Schreuder, Hélène Bourdon, Jan Hoflack
Publikováno v:
Journal of Computer-Aided Molecular Design. 11:317-332
Our model of the human m1 muscarinic receptor has been refined on the basis of the recently published projection map of bovine rhodopsin. The refined model has a slightly different helix arrangement, which reveals the presence of an extra hydrophobic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e00f8fca1ec3915cd48476fd8001c12
https://doi.org/10.1023/a:1007963327888
https://doi.org/10.1023/a:1007963327888
Autor:
Robert Boigegrain, Jean-Paul Kan, Dominique Olliero, Roger Brodin, Philippe Soubrié, Jean-Jacques Bourguignon, Camille-Georges Wermuth
Publikováno v:
European Journal of Medicinal Chemistry. 30:175s-185s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2000e0a8b20cd451eed70faba8b007fa
https://doi.org/10.1016/s0223-5234(23)00123-x
https://doi.org/10.1016/s0223-5234(23)00123-x
Publikováno v:
Polypharmacology in Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18d3f48148bfdb4f1d4fb88d202b1aab
https://doi.org/10.1002/9781118098141.ch11
https://doi.org/10.1002/9781118098141.ch11
Publikováno v:
Tetrahedron Letters. 35:6883-6886
TMSOTf-promoted reaction of heteroaromatic imines or hydroxyaminal intermediates with various enolic ketones are reported. This reaction constitutes an original and regioselective mode of alkylation of exocyclic amines of heterocyclic amidines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1426540042d9b9205f6c13560cebb7de
https://doi.org/10.1016/0040-4039(94)85031-3
https://doi.org/10.1016/0040-4039(94)85031-3