Zobrazeno 1 - 10
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pro vyhledávání: '"Camille G. Wermuth"'
Autor:
Camille G. Wermuth
Publikováno v:
MedChemComm. 2:935-941
One can estimate that about 50% of all the drug molecules used in medicine contain a phenyl ring which can be substituted or not. The bioisosteric replacement of these phenyl rings by the corresponding pyridazine rings opens an access to several thou
Autor:
Camille G. Wermuth
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery. :167-180
Publikováno v:
The Practice of Medicinal Chemistry (Second Edition)
This chapter is presenting the various strategies used to find pertinent compounds as starting points for optimization up to a drug. The discovery strategies from the historical ones to the most modern approaches are reviewed. They consist into mainl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9727bf5ea941005e03995803a8c9097c
https://doi.org/10.1016/b978-0-12-417205-0.00004-3
https://doi.org/10.1016/b978-0-12-417205-0.00004-3
The subsequent section describes the prodrug concept, the problems of the parent drug that prodrugs can overcome, the design aspects, and the difficulties associated with the clinical development of a prodrug. The chapter expands on the recent develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::259579baef9ccd9fe14a26388c872fb3
https://doi.org/10.1016/b978-0-12-417205-0.00028-6
https://doi.org/10.1016/b978-0-12-417205-0.00028-6
This chapter describes a panel of strategies used by medicinal chemists to establish the preliminary Structure-Activity Relationship (SAR) of biologically relevant starting points. These approaches depend on the level of information on the target and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb47eeacb52e19c288df873c8118ab50
https://doi.org/10.1016/b978-0-12-417205-0.00012-2
https://doi.org/10.1016/b978-0-12-417205-0.00012-2
Autor:
Anne Badel, Patrick Bazzini, Frans M. Belpaire, Alexandre Borrel, Koen Boussery, Christopher Brice, Anne-Claude Camproux, David Cavalla, Paola Ciapetti, Hongming Chen, Yong Mi Choi-Sledeski, Bernd Clement, Gordon M. Cragg, Patrick M. Dansette, Pierre deMontigny, Ji-Cui Dong, Iain G. Dougall, Ola Engkvist, Bernard Faller, Bennett T. Farmer, Delphine Flatters, Bruno Galli, Colette Geneix, Bruno Giethlen, Serge Grisoni, Gerhard Gross, David Harris, Yuichi Hashimoto, Chris Ho, Andrew L. Hopkins, Hiba Abi Hussein, Peter Imming, Minoru Ishikawa, Tim Jonckers, Sabine Kopp, David G.I. Kingston, Thierry Kogej, Sophie Lasseur, Dominique Lesuisse, Harvey Lieberman, Richard Luthi, Anne-Christine Macherey, André Mann, Raffaella G. Balocco Mattavelli, Christophe Morice, Richard Morphy, David J. Newman, Anne Olivier, Michel Petitjean, Pierre Raboisson, Zoran Rankovic, Leslie Regad, Allen B. Reitz, Bernd U. Riebesehl, Jean-Philippe Rocher, Tiago Rodrigues, A. Romeo, Jean-Michel Rondeau, Laurent Schaeffer, Jean-Michel Scherrmann, Gisbert Schneider, Herman Schreuder, Wolfgang Sippl, Erin M. Skoda, Olivier Taboureau, Bernard Testa, John Unitt, Johan Van de Voorde, Walter M.M. Van den Broeck, N. Murti Vemuri, Venkata Velvadapu, Franz Weiberth, Bruno Villoutreix, Camille G. Wermuth, Peter Wipf, Gerhard Wolber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ac78ac235601f775503cbb8ecc81d18
https://doi.org/10.1016/b978-0-12-417205-0.00044-4
https://doi.org/10.1016/b978-0-12-417205-0.00044-4
Autor:
Camille G. Wermuth, Dominique Lesuisse
This chapter describes a strategy that aims to convert a water-insoluble drug into water soluble one by attaching covalently an appropriate solubilizing side chain. Two distinct strategies can be used depending if the solubilizing moiety should be fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1f375cff65e0be2be356505d3d9efac
https://doi.org/10.1016/b978-0-12-417205-0.00030-4
https://doi.org/10.1016/b978-0-12-417205-0.00030-4