Long term exposure to environmental concentrations of diesel exhaust particles does not impact the phenotype of human bronchial epithelial cells

Autor: Nessrine Bellamri, Camille C Savary, Sophie Langouët, Laurent Vernhet, Valérie Lecureur, Claudie Morzadec

Publikováno v: Toxicology in Vitro
Toxicology in Vitro, 2018, 52, pp.154-160. ⟨10.1016/j.tiv.2018.06.014⟩
Toxicology in Vitro, Elsevier, 2018, 52, pp.154-160. ⟨10.1016/j.tiv.2018.06.014⟩

International audience; Chronic exposure to diesel engine exhausts is associated with an increased risk of pulmonary diseases including lung cancer. Diesel engine exhausts contain large amounts of diesel exhaust particles (DEP) on which are adsorbed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18bccb6c87d5161af56aa02204bbce5
https://doi.org/10.1016/j.tiv.2018.06.014

In vitro kinetics of amiodarone and its major metabolite in two human liver cell models after acute and repeated treatments

Autor: Emma Di Consiglio, Lysiane Richert, Emanuela Testai, André Guillouzo, Giuliana Pomponio, L. Romanelli, Frédéric Y. Bois, Céline Parmentier, Camille C Savary

Publikováno v: Toxicology in Vitro
Toxicology in Vitro, 2015, 30 (1 part A), pp.36-51. ⟨10.1016/j.tiv.2014.12.012⟩
Toxicology in Vitro, Elsevier, 2015, 30 (1 part A), pp.36-51. ⟨10.1016/j.tiv.2014.12.012⟩

The limited value of in vitro toxicity data for the in vivo extrapolation has been often attributed to the lack of kinetic data. Here the in vitro kinetics of amiodarone (AMI) and its mono-N-desethyl (MDEA) metabolite was determined and modelled in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee810fac8cd5853c760b16cbe7f947e3
https://univ-rennes.hal.science/hal-01134698

Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period

Autor: Xiaoqi Jiang, Philip G. Hewitt, Annette Kopp-Schneider, André Guillouzo, Camille C Savary, Marc Aubry, Rozenn Jossé

Publikováno v: Toxicology in Vitro
Toxicology in Vitro, 2015, 30 (1), pp.27-35. ⟨10.1016/j.tiv.2014.12.019⟩
Toxicology in Vitro, Elsevier, 2015, 30 (1), pp.27-35. ⟨10.1016/j.tiv.2014.12.019⟩

Previous works have shown that differentiated human HepaRG cells can exhibit drug metabolism activities close to those of primary human hepatocytes for several weeks at confluence. The present study was designed to evaluate their long-term functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816f9b191a1909f6f1867abffaaa1eb2
https://univ-rennes.hal.science/hal-01128182

Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells

Autor: Houssein Al-Attrache, Ziad Abdel-Razzak, Isabelle Morel, André Guillouzo, Camille C Savary, Sylvie Lepage, Ahmad Sharanek, Pamela Bachour-El Azzi, Gilles Labbe, Christiane Guguen-Guillouzo, Sébastien Anthérieu

Publikováno v: Drug Metabolism and Disposition
Drug Metabolism and Disposition, American Society for Pharmacology and Experimental Therapeutics (ASPET), 2014, 42 (9), pp.1556-66. ⟨10.1124/dmd.114.058123⟩
Drug Metabolism and Disposition, 2014, 42 (9), pp.1556-66. ⟨10.1124/dmd.114.058123⟩

International audience; Several factors are thought to be implicated in the occurrence of idiosyncratic adverse drug reactions. The present work aimed to question as to whether inflammation is a determinant factor in hepatic lesions induced by chlorp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14651d0235a8c0cfb1c01f67cbec7c2
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134764

Interactions of endosulfan and methoxychlor involving CYP3A4 and CYP2B6 in human HepaRG cells

Autor: Fabrice Guillet, Camille C Savary, André Guillouzo, Rozenn Jossé, Marie-Anne Robin, Arnaud Bruyère

Publikováno v: Drug Metabolism and Disposition
Drug Metabolism and Disposition, 2014, 42 (8), pp.1235-40. ⟨10.1124/dmd.114.057786⟩
Drug Metabolism and Disposition, American Society for Pharmacology and Experimental Therapeutics (ASPET), 2014, 42 (8), pp.1235-40. ⟨10.1124/dmd.114.057786⟩

International audience; Humans are usually exposed to several pesticides simultaneously; consequently, combined actions between pesticides themselves or between pesticides and other chemicals need to be addressed in the risk assessment. Many pesticid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93231297f1d8fc6ae6c42b50ffa3e59
https://pubmed.ncbi.nlm.nih.gov/24832206