Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Camille Brochier"'
Autor:
Nassim Hammoudi, Sarah Hamoudi, Julie Bonnereau, Hugo Bottois, Kevin Pérez, Madeleine Bezault, Déborah Hassid, Victor Chardiny, Céline Grand, Brice Gergaud, Joëlle Bonnet, Leila Chedouba, My-Linh Tran Minh, Jean-Marc Gornet, Clotilde Baudry, Hélène Corte, Léon Maggiori, Antoine Toubert, Jacqueline McBride, Camille Brochier, Margaret Neighbors, Lionel Le Bourhis, Matthieu Allez
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Lympho-epithelial interactions between intestinal T resident memory cells (Trm) and the epithelium have been associated with inflammatory bowel disease (IBD) activity. We developed ex vivo autologous organoid-mucosal T cell cocultures to functionally
Externí odkaz:
https://doaj.org/article/e70bb9e58fcf4c67a6a83e0226035adb
Autor:
Linda Bilonda Mutala, Cécile Deleine, Matilde Karakachoff, Delphine Dansette, Kathleen Ducoin, Romain Oger, Olivia Rousseau, Juliette Podevin, Emilie Duchalais, Pierre Fourquier, Wassila El Alami Thomas, Pierre-Antoine Gourraud, Jaafar Bennouna, Camille Brochier, Nadine Gervois, Céline Bossard, Anne Jarry
Publikováno v:
Cancers, Vol 13, Iss 2, p 189 (2021)
In colorectal cancer (CRC), a high density of T lymphocytes represents a strong prognostic marker in subtypes of CRC. Optimized immunotherapy strategies to boost this T-cell response are still needed. A good candidate is the inflammasome pathway, an
Externí odkaz:
https://doaj.org/article/9f3035250a6241a29301a83566d5cdba
Autor:
Irina G. Gazaryan, Anatoly A. Starkov, Sama F. Sleiman, Brett Langley, Julie K. Andersen, Camille Brochier, Ambreena Siddiq, Manuela Basso, Gregory J. Riggins, Thong C. Ma, Hossein Aleyasin, Susan Bane, Saravanan S. Karuppagounder, Rajiv R. Ratan, Shankar J. Chinta, Renée E. Haskew-Layton, Amit Kumar
Publikováno v:
Antioxidants & Redox Signaling. 22:121-134
Aims: Pharmacological activation of the adaptive response to hypoxia is a therapeutic strategy of growing interest for neurological conditions, including stroke, Huntington's disease, and Parkinson's disease. We screened a drug library with known saf
Autor:
Camille Brochier, Kathryn McLaughlin, Gretel Dennis, Rajiv R. Ratan, Giovanni Coppola, Brett Langley, Mark A. Rivieccio
Publikováno v:
The Journal of Neuroscience. 33:8621-8632
Histone deacetylase (HDAC) inhibitors have been used to promote neuronal survival and ameliorate neurological dysfunction in a host of neurodegenerative disease models. The precise molecular mechanisms whereby HDAC inhibitors prevent neuronal death a
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(49)
Therapeutic options for the restoration of neurological functions after acute axonal injury are severely limited. In addition to limiting neuronal loss, effective treatments face the challenge of restoring axonal growth within an injury environment w
Autor:
Breset A. Walker, Rajiv R. Ratan, Dianna E. Willis, Camille Brochier, Mark A. Rivieccio, Samie R. Jaffrey, Jeffery L. Twiss, Ambreena Siddiq, Brett Langley, Melissa A. D'Annibale, Alan P. Kozikowski, Kathryn McLaughlin
Publikováno v:
Proceedings of the National Academy of Sciences. 106:19599-19604
Central nervous system (CNS) trauma can result in tissue disruption, neuronal and axonal degeneration, and neurological dysfunction. The limited spontaneous CNS repair in adulthood and aging is often insufficient to overcome disability. Several inves
Autor:
Alan P. Kozikowski, Wayne W. Hancock, Camille Brochier, Gian Paolo Vallerini, Brett Langley, Mariana C. F. Segretti, Liqing Wang
Several new mercaptoacetamides were synthesized and studied as HDAC6 inhibitors. One compound, 2b, bearing an aminoquinoline cap group, was found to show 1.3 nM potency at HDAC6, with >3000-fold selectivity over HDAC1. 2b also showed excellent effica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0783656c3297658b03f10db0d5220044
https://europepmc.org/articles/PMC4645251/
https://europepmc.org/articles/PMC4645251/
Autor:
M. de Chaldée, Marie-Claude Gaillard, Jean-Marc Elalouf, R. Luthi-Carter, Camille Brochier, A. Van de Vel, Nicolas Caudy
Publikováno v:
Genomics. 87(2):200-207
In an initial study, we compared quantitative transcriptome data across mouse brain territories using the serial analysis of gene expression method. Among the novel regional markers that we discovered, we focused on a striatum-enriched transcript wit
Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A
Autor:
Jay H. Kalin, Camille Brochier, Brett Langley, Kyle V. Butler, Guilio Vistoli, Alan P. Kozikowski
Structure-based drug design combined with homology modeling techniques were used to develop potent inhibitors of HDAC6 that display superior selectivity for the HDAC6 isozyme compared to other inhibitors. These inhibitors can be assembled in a few sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea3d77c4a74847e67e1a3c1a1d67a59
https://europepmc.org/articles/PMC2916045/
https://europepmc.org/articles/PMC2916045/
Publikováno v:
Stroke. 40(8)
Achieving therapeutic efficacy in ischemic stroke represents one of the biggest challenges in translational neurobiology. Despite extensive efforts, tissue plasminogen activator remains the only available intervention for enhancing functional recover