Výsledky vyhledávání - "Camilla Pease"

Akademický článek

Implementing systematic review techniques in chemical risk assessment: Challenges, opportunities and recommendations

Publikováno v: Environment International, Vol 92, Iss , Pp 556-564 (2016)

Systematic review (SR) is a rigorous, protocol-driven approach designed to minimise error and bias when summarising the body of research evidence relevant to a specific scientific question. Taking as a comparator the use of SR in synthesising researc

Externí odkaz: https://doaj.org/article/239cc3272f7a4143bb6ab6459677f018

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Review of the Evidence from Epidemiology, Toxicology, and Lung Bioavailability on the Carcinogenicity of Inhaled Iron Oxide Particulates

Autor: Thomas Birk, Camilla Pease, Thomas Rücker

Publikováno v: Chemical research in toxicology. 29(3)

Since the iron-age and throughout the industrial age, humans have been exposed to iron oxides. Here, we review the evidence from epidemiology, toxicology, and lung bioavailability as to whether iron oxides are likely to act as human lung carcinogens.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc4b9ecc6ad634130ddf07a5716211f
https://pubmed.ncbi.nlm.nih.gov/26863929

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Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes

Autor: Carsten Goebel, Christine Götz, Ulrike Hübenthal, Karsten Ruwiedel, Roland Pfeiffer, Ellen Fritsche, Julia Tigges, Josef Abel, Jean Krutmann, Nicola J. Hewitt, Hans F. Merk, Camilla Pease, Robert Edwards

Publikováno v: Experimental Dermatology. 21:364-369

The 7th Amendment to the EU Cosmetics Directive prohibits the use of animals in cosmetic testing for certain endpoints, such as genotoxicity. Therefore, skin in vitro models have to replace chemical testing in vivo. However, the metabolic competence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0b905320c8532557a3e5a6f5890259d
https://doi.org/10.1111/j.1600-0625.2012.01478.x

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Determining Epidermal Disposition Kinetics for Use in an Integrated Nonanimal Approach to Skin Sensitization Risk Assessment

Autor: Leanne Page, Ruth U. Pendlington, David J. Sanders, Clare Bourner, Cameron MacKay, Michael Davies, Clive Roper, Camilla Pease

Publikováno v: Toxicological Sciences. 119:308-318

Development of risk assessment methods for skin sensitization in the absence of toxicological data generated in animals represents a major scientific and technical challenge. The first step in human skin sensitization induction is the transport of se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce197c0908387f1814b1b6183e00285
https://doi.org/10.1093/toxsci/kfq326

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Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals

Autor: Sidonie N. Lavergne, Claire Jenkinson, Clodagh M. King, Maja Aleksic, Andrew White, Munir Pirmohamed, David A. Basketter, B. Kevin Park, Camilla Pease, Eve Coulter, John Farrell, Dean J. Naisbitt, Dominic P. Williams

Publikováno v: Journal of Investigative Dermatology. 130:161-174

Factors predisposing to individual susceptibility to contact allergic dermatitis are ill defined. This study was designed to characterize the response of allergic and tolerant individuals' T-lymphocytes after exposure to p-phenylenediamine (PPD). Per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b155dd8edd9ca1048af2f56abc4ab0f2
https://doi.org/10.1038/jid.2009.187

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Mass spectrometric identification of covalent adducts of the skin allergen 2,4-dinitro-1-chlorobenzene and model skin proteins

Autor: Anne Dell, David A. Basketter, Maria Panico, Maja Aleksic, Camilla Pease, Howard R. Morris

Publikováno v: Toxicology in Vitro. 22:1169-1176

A large proportion of allergic skin reactions are considered to be the result of skin exposure to small organic chemicals that possess the intrinsic ability to covalently modify skin proteins, either directly or following activation. In the absence o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a87f2aea20881d8872a93089996cde
https://doi.org/10.1016/j.tiv.2008.03.006

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Activation of T-Cells from Allergic Patients and Volunteers by p-Phenylenediamine and Bandrowski's Base

Autor: John Farrell, David A. Basketter, Munir Pirmohamed, Ying Wu, Brian Kevin Park, Claire Jenkinson, Camilla Pease, Brian Foster, Andrew M. Smith, Clodagh M. King, Carolann McGuire, Peter S. Friedmann, Eve Coulter, Dean J. Naisbitt

Publikováno v: Journal of Investigative Dermatology. 128:897-905

Allergic contact dermatitis is commonly associated with exposure to p-phenylenediamine. The aim of this study was to determine whether p-phenylenediamine (PPD) and/or Bandrowski's base (BB) stimulate T cells from allergic patients and volunteers, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff751e2fa77689ef9e250ad5ae9354f
https://doi.org/10.1038/sj.jid.5701071

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Development of a ModifiedIn vitroSkin Absorption Method to Study the Epidermal/Dermal Disposition of a Contact Allergen in Human Skin

Autor: David J. Sanders, Leanne Stupart, Clive Roper, Cameron MacKay, Ruth U. Pendlington, Camilla Pease, Helen J Minter

Publikováno v: Cutaneous and Ocular Toxicology. 27:283-294

In vitro skin absorption methods exist in Organisation for Economic Co-operation and Development (OECD) guideline form (No. 428) and are used to estimate the degree of systemic penetration of chemicals through skin. More detailed kinetics of permeati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e716358b426eacf3f23d843c1b9c584c
https://doi.org/10.1080/15569520802327005

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Chemical reactivity indices and mechanism-based read-across for non-animal based assessment of skin sensitisation potential

Autor: Aynur O. Aptula, David W. Roberts, Camilla Pease, Grace Patlewicz

Publikováno v: Journal of Applied Toxicology. 28:443-454

The skin sensitisation potential of chemicals is currently assessed using in vivo methods where the murine local lymph node assay (LLNA) is typically the method of first choice. Current regulatory initiatives are driving the impetus for the use of in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c67b800b8b843dc7bc151f6e29d655
https://doi.org/10.1002/jat.1293

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