Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects

Autor: Stine Brinkløv Thomsen, Camilla Noelle Rathcke, Nils Bruun Jørgensen, Sten Madsbad, Henrik Vestergaard

Publikováno v: Journal of Obesity, Vol 2013 (2013)

Background. The inflammatory markers YKL-40 and monocyte chemoattractant protein-1 (MCP-1) are elevated in morbidly obese patients and decline after weight loss. The objective of our study was to investigate the possible changes of YKL-40 and MCP-1,

Externí odkaz: https://doaj.org/article/0992fb5f517448298c7dc3e3de6218cf

Variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and prediction of fatal and non-fatal ischemic stroke.

Autor: Camilla Noelle Rathcke, Stine Brinkloev Thomsen, Allan Linneberg, Henrik Vestergaard

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e43498 (2012)

Polymorphisms of CHI3L1 are associated with inter-individual YKL-40 levels and YKL-40 is associated with an increased mortality and is elevated in patients with cardiovascular disease. We investigated the association between single nucleotide polymor

Externí odkaz: https://doaj.org/article/f6146edb61f14a32b0af2405154056e1

Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults.

Autor: Camilla Noelle Rathcke, Johan Holmkvist, Lise Lotte N Husmoen, Torben Hansen, Oluf Pedersen, Henrik Vestergaard, Allan Linneberg

Publikováno v: PLoS ONE, Vol 4, Iss 7, p e6106 (2009)

YKL-40 is a chitinase-like glycoprotein encoded by the chitinase 3-like 1 gene, CHI3L1, localized at chromosome 1q32.1. Increased levels of serum YKL-40 have been reported to be a biomarker for asthma and a reduced lung function. Interestingly, the C

Externí odkaz: https://doaj.org/article/8645bc7b7160486193f89ef6185df85d

Low grade inflammation as measured by levels of YKL-40: Association with an increased overall and cardiovascular mortality rate in an elderly population

Autor: Jens Faber, Ilan Raymond, Henrik Vestergaard, Per Hildebrandt, Caroline Kistorp, Camilla Noelle Rathcke

Publikováno v: International Journal of Cardiology. 143:35-42

Background Low grade inflammation is of pathogenic importance in the development of cardiovascular disease (CVD) and type 2 diabetes. The inflammation marker YKL-40 correlates with insulin resistance and is highly expressed in atherosclerotic plaques

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55714ecb5e17a4ecd35cf62feea10feb
https://doi.org/10.1016/j.ijcard.2009.01.043

Associations of the Inflammatory Marker YKL-40 with Measures of Obesity and Dyslipidaemia in Individuals at High Risk of Type 2 Diabetes

Autor: Torben Hansen, Camilla Noelle Rathcke, Anette P. Gjesing, Henrik Vestergaard, Claus Thorn Ekstrøm, Stine Brinkløv Thomsen, Hans Eiberg, Oluf Pedersen

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 7, p e0133672 (2015)
Thomsen, S B, Gjesing, A P, Rathcke, C N, Ekstrom, C T, Eiberg, H, Hansen, T, Pedersen, O & Vestergaard, H 2015, ' Associations of the Inflammatory Marker YKL-40 with Measures of Obesity and Dyslipidaemia in Individuals at High Risk of Type 2 Diabetes ', P L o S One, vol. 10, no. 7, e0133672 . https://doi.org/10.1371/journal.pone.0133672

INTRODUCTION: Circulating levels of the inflammatory marker YKL-40 are elevated in cardiovascular disease and obesity-related type 2 diabetes (T2D), and serum YKL-40 levels are related to elements of dyslipidaemia.OBJECTIVE: We aimed to investigate t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9dd0557fec73f3f98313b47f2d776b
http://europepmc.org/articles/PMC4510434