The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders.

Autor: Mette K Andersen, Emil Jørsboe, Line Skotte, Kristian Hanghøj, Camilla H Sandholt, Ida Moltke, Niels Grarup, Timo Kern, Yuvaraj Mahendran, Bolette Søborg, Peter Bjerregaard, Christina V L Larsen, Inger K Dahl-Petersen, Hemant K Tiwari, Bjarke Feenstra, Anders Koch, Howard W Wiener, Scarlett E Hopkins, Oluf Pedersen, Mads Melbye, Bert B Boyer, Marit E Jørgensen, Anders Albrechtsen, Torben Hansen

Publikováno v: PLoS Genetics, Vol 16, Iss 1, p e1008544 (2020)

The genetic architecture of the small and isolated Greenlandic population is advantageous for identification of novel genetic variants associated with cardio-metabolic traits. We aimed to identify genetic loci associated with body mass index (BMI), t

Externí odkaz: https://doaj.org/article/31a1e3c4b2684f3ca2c1fe7ceb71c161

Physical activity and insulin sensitivity independently attenuate the effect of FTO rs9939609 on obesity

Autor: Torben Hansen, Christopher J. Rhodes, Joseph Grimsby, Allan Linneberg, Thorkild I A. Sørensen, Romain Barrès, Kristine Williams, Oluf Pedersen, Arne Astrup, Niels Grarup, Emily L. Ongstad, Laura Maarit Pikkupeura, Malte Thodberg, Camilla H. Sandholt, Sara E. Stinson, Anna E. Jonsson, Jette Bork-Jensen, Lars Ängquist, Mette K. Andersen

Objective The association between FTO rs9939609 and obesity is modified by physical activity (PA) and/or insulin sensitivity (IS). We aimed to assess whether these modifications are independent, if PA and/or IS modify the association between rs993960

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c70d690deced65ff86ac76eb087ca8
https://doi.org/10.2337/figshare.22006433.v1

Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets.

Autor: Niels Grarup, Patrick Sulem, Camilla H Sandholt, Gudmar Thorleifsson, Tarunveer S Ahluwalia, Valgerdur Steinthorsdottir, Helgi Bjarnason, Daniel F Gudbjartsson, Olafur T Magnusson, Thomas Sparsø, Anders Albrechtsen, Augustine Kong, Gisli Masson, Geng Tian, Hongzhi Cao, Chao Nie, Karsten Kristiansen, Lise Lotte Husemoen, Betina Thuesen, Yingrui Li, Rasmus Nielsen, Allan Linneberg, Isleifur Olafsson, Gudmundur I Eyjolfsson, Torben Jørgensen, Jun Wang, Torben Hansen, Unnur Thorsteinsdottir, Kari Stefánsson, Oluf Pedersen

Publikováno v: PLoS Genetics, Vol 9, Iss 6, p e1003530 (2013)

Genome-wide association studies have mainly relied on common HapMap sequence variations. Recently, sequencing approaches have allowed analysis of low frequency and rare variants in conjunction with common variants, thereby improving the search for fu

Externí odkaz: https://doaj.org/article/a38c08cfe1254dde87208308ff6b5481

The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders

Autor: Marit E. Jørgensen, Bjarke Feenstra, Anders Koch, Camilla H. Sandholt, Mads Melbye, Yuvaraj Mahendran, Scarlett E. Hopkins, Oluf Pedersen, Anders Albrechtsen, Howard W. Wiener, Timo Kern, Peter Bjerregaard, Hemant K. Tiwari, Torben Hansen, Mette K. Andersen, Ida Moltke, Line Skotte, Inger Katrine Dahl-Petersen, Christina Viskum Lytken Larsen, Niels Grarup, Bolette Søborg, Kristian Hanghøj, Bert B. Boyer, Emil Jørsboe

Publikováno v: PLoS Genetics, Vol 16, Iss 1, p e1008544 (2020)
Andersen, M K, Jørsboe, E, Skotte, L, Hanghøj, K, Sandholt, C H, Moltke, I, Grarup, N, Kern, T, Mahendran, Y, Søborg, B, Bjerregaard, P, Larsen, C V L, Dahl-Petersen, I K, Tiwari, H K, Feenstra, B, Koch, A, Wiener, H W, Hopkins, S E, Pedersen, O, Melbye, M, Boyer, B B, Jørgensen, M E, Albrechtsen, A & Hansen, T 2020, ' The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders ', PLOS Genetics, vol. 16, no. 1, pp. e1008544 . https://doi.org/10.1371/journal.pgen.1008544
Andersen, M K, Jørsboe, E, Skotte, L, Hanghøj, K, Sandholt, C H, Moltke, I, Grarup, N, Kern, T, Mahendran, Y, Søborg, B, Bjerregaard, P, Larsen, C V L, Dahl-Petersen, I K, Tiwari, H K, Feenstra, B, Koch, A, Wiener, H W, Hopkins, S E, Pedersen, O, Melbye, M, Boyer, B B, Jørgensen, M E, Albrechtsen, A & Hansen, T 2020, ' The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders ', PLOS Genetics, vol. 16, no. 1, e1008544 . https://doi.org/10.1371/journal.pgen.1008544
PLoS Genetics

The genetic architecture of the small and isolated Greenlandic population is advantageous for identification of novel genetic variants associated with cardio-metabolic traits. We aimed to identify genetic loci associated with body mass index (BMI), t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa70a42c65e7dcc6c2748ac8d4992940
https://doaj.org/article/31a1e3c4b2684f3ca2c1fe7ceb71c161

Bioinformatics-driven identification and examination of candidate genes for non-alcoholic fatty liver disease.

Autor: Karina Banasik, Johanne M Justesen, Malene Hornbak, Nikolaj T Krarup, Anette P Gjesing, Camilla H Sandholt, Thomas S Jensen, Niels Grarup, Asa Andersson, Torben Jørgensen, Daniel R Witte, Annelli Sandbæk, Torsten Lauritzen, Bernard Thorens, Søren Brunak, Thorkild I A Sørensen, Oluf Pedersen, Torben Hansen

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e16542 (2011)

Candidate genes for non-alcoholic fatty liver disease (NAFLD) identified by a bioinformatics approach were examined for variant associations to quantitative traits of NAFLD-related phenotypes.By integrating public database text mining, trans-organism

Externí odkaz: https://doaj.org/article/0cbd53982403493c882e8efdca4fdc26