Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity

Autor: Ophir Shani, Yael Raz, Lea Monteran, Ye'ela Scharff, Oshrat Levi-Galibov, Or Megides, Hila Shacham, Noam Cohen, Dana Silverbush, Camilla Avivi, Roded Sharan, Asaf Madi, Ruth Scherz-Shouval, Iris Barshack, Ilan Tsarfaty, Neta Erez

Publikováno v: eLife, Vol 10 (2021)

Mortality from breast cancer is almost exclusively a result of tumor metastasis, and lungs are one of the main metastatic sites. Cancer-associated fibroblasts are prominent players in the microenvironment of breast cancer. However, their role in the

Externí odkaz: https://doaj.org/article/c920622612bb4137aabc24c393bb62d6

Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity

Autor: Iris Barshack, Asaf Madi, Noam Cohen, Roded Sharan, Lea Monteran, Neta Erez, Ruth Scherz-Shouval, Ye'ela Scharff, Dana Silverbush, Yael Raz, Ophir Shani, Or Megides, Hila Shacham, Ilan Tsarfaty, Camilla Avivi, Oshrat Levi-Galibov

Publikováno v: eLife
eLife, Vol 10 (2021)

Mortality from breast cancer is almost exclusively a result of tumor metastasis, and lungs are one of the main metastatic sites. Cancer-associated fibroblasts are prominent players in the microenvironment of breast cancer. However, their role in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481f9e05ab3d0bf596aea0fe3667c68a
http://europepmc.org/articles/PMC8257251

Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy

Autor: Arcangela Iuso, Nicola A. Grzeschik, Holger Prokisch, Iris Barshack, Muhamad Kumbar, Bart Kanon, Thomas Schwarzmayr, Gal Dubnov-Raz, Dorothea Haas, Riccardo Berutti, Bader Alhaddad, Marit Wiersma, Zeev Perles, Ben Pode-Shakked, Georg F. Hoffmann, Mathias Grigat, Tal Tirosh, Caterina Terrile, Elisa Mastantuono, Tim M. Strom, Jürgen G. Okun, Marina Rubinshtein, Matthias C. Braunisch, Yair Anikster, Shachar Abudi, Camilla Avivi, Ana C. Messias, Amir Vardi, Brundel Bianca Johanna Josephina Maria, Ody C. M. Sibon, Eran Eyal, Dina Marek-Yagel, Tobias B. Haack, Yishay Salem, Thomas Meitinger, A Volkov, Ortal Barel, Hans Joachim Schüller

Publikováno v: American Journal of Human Genetics, 102(6), 1018-1030. CELL PRESS
Am. J. Hum. Genet. 102, 1018-1030 (2018)
The American Journal of Human Genetics
Iuso, A, Wiersma, M, Schüller, H J, Pode-Shakked, B, Marek-Yagel, D, Grigat, M, Schwarzmayr, T, Berutti, R, Alhaddad, B, Kanon, B, Grzeschik, N A, Okun, J G, Perles, Z, Salem, Y, Barel, O, Vardi, A, Rubinshtein, M, Tirosh, T, Dubnov-Raz, G, Messias, A C, Terrile, C, Barshack, I, Volkov, A, Avivi, C, Eyal, E, Mastantuono, E, Kumbar, M, Abudi, S, Braunisch, M, Strom, T M, Meitinger, T, Hoffmann, G F, Prokisch, H, Haack, T B, Brundel, B J J M, Haas, D, Sibon, O C M & Anikster, Y 2018, ' Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy ', American journal of human genetics, vol. 102, no. 6, pp. 1018-1030 . https://doi.org/10.1016/j.ajhg.2018.03.022
American journal of human genetics, 102(6), 1018-1030. Cell Press

Coenzyme A (CoA) is an essential metabolic cofactor used by around 4% of cellular enzymes. Its role is to carry and transfer acetyl and acyl groups to other molecules. Cells can synthesize CoA de novo from vitamin B5 (pantothenate) through five conse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3fe09634366ceea231486e183784a57
http://www.scopus.com/inward/record.url?scp=85046776501&partnerID=8YFLogxK

System-wide Clinical Proteomics of Breast Cancer Reveals Global Remodeling of Tissue Homeostasis

Autor: Iris Barshack, Cecilia Lindskog, Tamar Geiger, Nora Balint-Lahat, Rotem Katzir, Fredrik Pontén, Jan Daniel Rudolph, Camilla Avivi, Yair Pozniak, Eytan Ruppin

Publikováno v: Cell Systems. 2(3):172-184

The genomic and transcriptomic landscapes of breast cancer have been extensively studied, but the proteomes of breast tumors are far less characterized. Here, we use high-resolution, high-accuracy mass spectrometry to perform a deep analysis of lumin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b13fdfd80e454cf791891b102fc4e4b

Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors

Autor: Sarah Glanz, Yael Raz, Neta Erez, Iris Barshack, Camilla Avivi

Publikováno v: Biochemical and biophysical research communications. 437(3)

Inflammation has been established in recent years as a hallmark of cancer. Cancer Associated Fibroblasts (CAFs) support tumorigenesis by stimulating angiogenesis, cancer cell proliferation and invasion. We previously demonstrated that CAFs also media

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4337d3e047f51ef39c6cb5a00d66a363
https://pubmed.ncbi.nlm.nih.gov/23831470