Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Camilla A. Hansson Petersen"'
γ-secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ42/Aβ40 ratio
Autor:
Lars O. Tjernberg, Louise Hedskog, Helena Karlström, Anne-Lie Svensson, Hedvig Welander, Maria Ankarcrona, Camilla A. Hansson Petersen
Publikováno v:
Journal of Cellular and Molecular Medicine
Markers for caspase activation and apoptosis have been shown in brains of Alzheimer's disease (AD) patients and AD-mouse models. In neurons, caspase activation is associated with elevated amyloid β-peptide (Aβ) production. Caspases cleave numerous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44381a110136e9024b57a739d7e0377
https://doi.org/10.1111/j.1582-4934.2010.01208.x
https://doi.org/10.1111/j.1582-4934.2010.01208.x
Publikováno v:
Journal of Cellular and Molecular Medicine
Accumulating evidence suggest that alterations in energy metabolism are among the earliest events that occur in the Alzheimer disease (AD) affected brain. Energy consumption is drastically decreased in the AD-affected regions of cerebral cortex and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8985a95397ae8fdfdd82317d11b7eed
https://doi.org/10.1111/j.1582-4934.2009.00892.x
https://doi.org/10.1111/j.1582-4934.2009.00892.x
Autor:
Ville Leinonen, Birgitta Wiehager, Bengt Winblad, Akira Ito, Nyosha Alikhani, Maria Ankarcrona, Pavel F. Pavlov, Camilla A. Hansson Petersen, Irina Alafuzoff, Homira Behbahani, Elzbieta Glaser
Publikováno v:
Proceedings of the National Academy of Sciences. 105:13145-13150
The amyloid β-peptide (Aβ) has been suggested to exert its toxicity intracellularly. Mitochondrial functions can be negatively affected by Aβ and accumulation of Aβ has been detected in mitochondria. Because Aβ is not likely to be produced local
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d597f2b97064213f29ac014639237cc0
https://doi.org/10.1073/pnas.0806192105
https://doi.org/10.1073/pnas.0806192105
Publikováno v:
Journal of Alzheimer's disease : JAD. 21(2)
Dimebon, a drug currently being evaluated in multiple Phase III Alzheimer's disease trials, has previously been shown to have effects on isolated mitochondria at muM concentrations. Here the effects of nM concentrations of Dimebon on mitochondrial fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25cfe88a38b832fb41be9a5b9354514
https://pubmed.ncbi.nlm.nih.gov/20555134
https://pubmed.ncbi.nlm.nih.gov/20555134