Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Camile P. Semighini"'
Autor:
Arielle Butts, Kristy Koselny, Yeissa Chabrier-Roselló, Camile P. Semighini, Jessica C. S. Brown, Xuying Wang, Sivakumar Annadurai, Louis DiDone, Julie Tabroff, Wayne E. Childers, Magid Abou-Gharbia, Melanie Wellington, Maria E. Cardenas, Hiten D. Madhani, Joseph Heitman, Damian J. Krysan
Publikováno v:
mBio, Vol 5, Iss 1 (2014)
ABSTRACT Cryptococcosis is an infectious disease of global significance for which new therapies are needed. Repurposing previously developed drugs for new indications can expedite the translation of new therapies from bench to beside. Here, we charac
Externí odkaz:
https://doaj.org/article/a47f62ddda0341948a47a260086195b2
Autor:
Steven D. Harris, Iran Malavazi, Gustavo H. Goldman, Marcia Regina von Zeska Kress, Camile P. Semighini
Publikováno v:
Genetics. 173:99-109
Ataxia telangiectasia (A-T) is an inherited disorder characterized by progressive loss of motor function and susceptibility to cancer. The most prominent clinical feature observed in A-T patients is the degeneration of Purkinje motor neurons. Numerou
Publikováno v:
Molecular Microbiology. 59:753-764
The dimorphic fungus Candida albicans secretes farnesol, which acts as a quorum-sensing molecule and prevents the yeast to mycelium conversion. In this study we examined the effect of farnesol in the filamentous fungus Aspergillus nidulans. We show t
Autor:
Marcela Savoldi, Steven D. Harris, Marcia Regina von Zeska Kress Fagundes, Joel Fernandes Lima, Maria Helena S. Goldman, Camile P. Semighini, Gustavo H. Goldman, Iran Malavazi
Publikováno v:
Eukaryotic Cell. 4:1239-1252
The ATM/ATR kinases and the Mre11 (Mre11-Rad50-Nbs1) protein complex are central players in the cellular DNA damage response. Here we characterize possible interactions between Aspergillus nidulans uvsB ATR and the Mre11 complex ( scaA NBS1 ). We dem
Publikováno v:
Genetics. 169:1391-1402
SepB is an essential, conserved protein required for chromosomal DNA metabolism in Aspergillus nidulans. Homologs of SepB include yeast Ctf4p and human hAnd-1. Molecular and bioinformatic characterization of these proteins suggests that they act as m
Autor:
Maria Helena S. Goldman, Renata C. Pascon, Camile P. Semighini, Joseane Cristina Ferreira, Gustavo H. Goldman, Marcia Regina von Zeska Kress Fagundes
Publikováno v:
Molecular Microbiology. 48:1693-1709
The Mre11-Rad50-Nbs1 protein complex has emerged as a central player In the cellular DNA damage response. Mutations In scaA N B S 1 , which encodes the apparent homologue of human Nbs1 in Aspergillus nidulans, inhibit growth in the presence of the an
Autor:
Maria Helena S. Goldman, Everaldo dos Reis Marques, Ana Paula Bogossian, Regina Costa de Oliveira, Fredj Tekaia, Marina P. Nobrega, Luiz R. Nunes, Patrícia Marostica Vitorelli, Camile P. Semighini, Marcela Savoldi, Luciano Ângelo de Souza Bernardes, Andréa Carla Quiapin, Leslie Ecker Ferreira, Gustavo H. Goldman, Rosana Puccia, Diógenes Custódio Duarte Ribeiro, Júlio C. Moreira, Luiz R. Travassos, Wagner L. Batista, Francisco G. Nobrega
Publikováno v:
Eukaryotic Cell. 2:34-48
Paracoccidioides brasiliensis , a thermodimorphic fungus, is the causative agent of the prevalent systemic mycosis in Latin America, paracoccidioidomycosis. We present here a survey of expressed genes in the yeast pathogenic phase of P. brasiliensis
Autor:
Zoilo P. de Camargo, Camile P. Semighini, Gustavo H. Goldman, Maria Helena S. Goldman, Rosana Puccia
Publikováno v:
Diagnostic Microbiology and Infectious Disease. 44:383-386
A PCR assay based on the 5' nuclease assay using a fluorescent probe derived from the sequence of the gene coding for the 43,000-Da (gp43) antigen was developed to detect Paracoccidioides brasiliensis. The assay could detect at least 10 copies of thi
Publikováno v:
Applied and Environmental Microbiology. 68:1351-1357
The development of assays for quantitative analysis of the relative transcript levels of ABC transporter genes by real-time reverse transcription-PCR (RT-PCR) might provide important information about multidrug resistance in filamentous fungi. Here,
Autor:
David S. Perlin, Gustavo H. Goldman, Guillaume Delmas, Steven Park, Camile P. Semighini, Donald Amstrong
Publikováno v:
FEMS Immunology & Medical Microbiology. 31:15-19
In this study, we isolated and tested restriction fragment length polymorphism (RFLP) markers for Aspergillus fumigatus based on PCR products amplified by the random amplified polymorphic DNA (RAPD) primer R108. Four DNA fragments, Afd, Af5, Af4, and