Personalised human albumin in patients with cirrhosis and ascites: design and rationale for the ALB-TRIAL - a randomised clinical biomarker validation trial

Autor: Torben Hansen, Pere Ginès, Wim Laleman, Peer Bork, Vishal C Patel, Debbie Shawcross, Robert Schierwagen, Camila Alvarez-Silva, Florence Servant, Jonel Trebicka, Benjamin Lelouvier, Manimozhiyan Arumugam, Ed J Kuijper, Frank Erhard Uschner, Michael Praktiknjo, Mária Papp, Saeed Shoaie, Michael Kühn, Maja Thiele, Paolo Angeli, Joan Claria, Vicente Arroyo, Manolo Laiola, Benoit Quinquis, Sabine Klein, Minneke J Coenraad, François Fenaille, Debbie Lindsay Shawcross, Wenyi Gu, Adria Juanola, Elisa Pose, Aleksander Krag, Ivica Letunic, Alain Pruvost, Hervé M Blottière, Nathalie Galleron, Cristina López-Vicario, Peter V Treit, Matthias Mann, Jelle Matthijnssens, Mark J W Mcphail, Philipp E Geyer, Hans Olav Melberg, Stefanie Kandels, Cristina Sánchez-Garrido, Florence A Castelli, Christophe Junot, Lars Asphaug, Mads Israelsen, Helene Bæk Juel, Nikolaj Torp, Minneke Coenraad, Marko Korenjak, Ferran Aguilar-Parera, Patricia Sierra-Casas, Anna Bosch-Comas, David Tornai, Boglarka Balogh, Katrine Holtz Thorhauge, Casper Sahl Poulsen, Thea Van Rossum, Suguru Nishijima, Marisa I Keller, Diënty H M Hazenbrink, Sylvain Dechaumet, Sebastian D Burz, Emeline Chu-Van, Etienne Thévenot, Florian A Rosenberger, Sebastian Van Blerk, Amirouche Ouzerdine, Alain Roulet, Jean-Louis-Marie Insonere, Céline Serres, Mathieu Almeida, Florence Thirion, Camille Champion, Chaima Ezzine, Célia Chamignon, Nicolas Lapaque, Mamadou Gabou Thiam, Lore Van Espen, Quinten R Ducarmon, Annelotte GC Broekhoven, Susan Fischer, Romy Zwittink, Itziar De Lecuona, Giulio Rosati, Celia Fuentes-Chust, Arben Merkoçi, Massimo Urban, José Alfonso Marrugo-Ramirez, Ameli Schwalber, Lindsey Ann Edwards, Victoria Tatiana Kronsten, David Moyes, Azadeh Harzandi, Jordi Gratacós-Ginès, Martina Pérez-Guasch, Miriam Pellón, Bryan Contreras, Max Brol, Manfred Fobker, Renata Antonina Feuerborn

Publikováno v: BMJ Open, Vol 14, Iss 2 (2024)

Introduction Human albumin is used in the treatment of complications of cirrhosis. However, the use of long-term human albumin administration is costly and resource demanding for both patients and healthcare systems. A precision medicine approach wit

Externí odkaz: https://doaj.org/article/289f12a27d2047adb5cb758cb2809703

Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways

Autor: Michael Jakob Pichler, Chihaya Yamada, Bashar Shuoker, Camila Alvarez-Silva, Aina Gotoh, Maria Louise Leth, Erwin Schoof, Toshihiko Katoh, Mikiyasu Sakanaka, Takane Katayama, Chunsheng Jin, Niclas G. Karlsson, Manimozhiyan Arumugam, Shinya Fushinobu, Maher Abou Hachem

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

The assembly and maturation of the early life microbiome has life-long effects on human health. Here, the authors combine omics, functional assays and structural analyses to characterize the catabolic pathways that support the growth of butyrate prod

Externí odkaz: https://doaj.org/article/93e13acc192c463a8e81c96141510b43

Ecological Adaptation and Succession of Human Fecal Microbial Communities in an Automated In Vitro Fermentation System

Autor: Thiyagarajan Gnanasekaran, Juliana Assis Geraldo, David Wilczek Ahrenkiel, Camila Alvarez-Silva, Carmen Saenz, Adnan Khan, Obaida Hanteer, Vithiagaran Gunalan, Kajetan Trost, Thomas Moritz, Manimozhiyan Arumugam

Publikováno v: mSystems, Vol 6, Iss 4 (2021)

ABSTRACT Longitudinal studies of gut microbiota following specific interventions are vital for understanding how they influence host health. However, robust longitudinal sampling of gut microbiota is a major challenge, which can be addressed using in

Externí odkaz: https://doaj.org/article/ef9825de10104c728fc4a5444da745f6

Astrocyte-Selective Volume Increase in Elevated Extracellular Potassium Conditions Is Mediated by the Na/K ATPase and Occurs Independently of Aquaporin 4

Autor: Erin Walch, Thomas R. Murphy, Nicholas Cuvelier, Murad Aldoghmi, Cristine Morozova, Jordan Donohue, Gaby Young, Anuja Samant, Stacy Garcia, Camila Alvarez, Alex Bilas, David Davila, Devin K. Binder, Todd A. Fiacco

Publikováno v: ASN Neuro, Vol 12 (2020)

Astrocytes and neurons have been shown to swell across a variety of different conditions, including increases in extracellular potassium concentration (^[K + ] o ). The mechanisms involved in the coupling of K + influx to water movement into cells le

Externí odkaz: https://doaj.org/article/d966672f518346958b529ddce501ad9d

Anthropocene and streamflow: Long-term perspective of streamflow variability and water rights

Autor: Pilar Barria, Maisa Rojas, Pilar Moraga, Ariel Muñoz, Deniz Bozkurt, Camila Alvarez-Garreton

Publikováno v: Elementa: Science of the Anthropocene, Vol 7, Iss 1 (2019)

Since 1981, water allocation in Chile has been based on a water use rights (WURs) market, with limited regulatory and supervisory mechanisms. The volume to be granted as permanent and eventual WURs is calculated from streamflow records, if stream gau

Externí odkaz: https://doaj.org/article/ab1cff23155446ebbaef9b260495e39f