Correlation between frataxin expression and contractility revealed by in vitro Friedreich’s ataxia cardiac tissue models engineered from human pluripotent stem cells

Autor: Andy On-Tik Wong, Gabriel Wong, Michael Shen, Maggie Zi-Ying Chow, Wan Wai Tse, Bimal Gurung, Suet Yee Mak, Deborah K. Lieu, Kevin D. Costa, Camie W. Chan, Alain Martelli, Joseph F. Nabhan, Ronald A. Li

Publikováno v: Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-11 (2019)

Abstract Background Friedreich’s ataxia (FRDA) is an autosomal recessive disease caused by a non-coding mutation in the first intron of the frataxin (FXN) gene that suppresses its expression. Compensatory hypertrophic cardiomyopathy, dilated cardio

Externí odkaz: https://doaj.org/article/c3b3d53d2d4149ee959b9aaaf70281c0

Probing flecainide block of I using human pluripotent stem cell-derived ventricular cardiomyocytes adapted to automated patch-clamping and 2D monolayers

Autor: Angie Man-Yee Shum, Andy On‑Tik Wong, Camie W. Chan, Chi-Wing Kong, Lin Geng, Ronald A. Li, Hui Che, Maggie Zi-Ying Chow, Ka-Long Yau, Chenzi Zhang, Wendy Keung

Publikováno v: Toxicology Letters. 294:61-72

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are emerging tools for applications such as drug discovery and screening for pro-arrhythmogenicity and cardiotoxicity as leading causes for drug attrition. Understanding the electrophysiol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52c66ef256e83ed06593e071ce32e1e7
https://doi.org/10.1016/j.toxlet.2018.05.006

Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification

Autor: Gabriel K.Y. Wong, Eugene K. Lee, David D. Tran, Ronald A. Li, Kevin D. Costa, Wendy Keung, Camie W. Chan, Patrick K. W. Chan, Michelle Khine

Publikováno v: Lee, EK; Tran, DD; Keung, W; Chan, P; Wong, G; Chan, CW; et al.(2017). Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification. STEM CELL REPORTS, 9(5), 1560-1572. doi: 10.1016/j.stemcr.2017.09.008. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/61z169c9
Stem Cell Reports, Vol 9, Iss 5, Pp 1560-1572 (2017)
Stem Cell Reports

Summary Accurately predicting cardioactive effects of new molecular entities for therapeutics remains a daunting challenge. Immense research effort has been focused toward creating new screening platforms that utilize human pluripotent stem cell (hPS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a07fcbf17682ddf7a8dc17495ce458
https://doi.org/10.1016/j.stemcr.2017.09.008

A Simple, Cost-Effective but Highly Efficient System for Deriving Ventricular Cardiomyocytes from Human Pluripotent Stem Cells

Autor: Zhihui Weng, Jiaozi He, Howard C.H. Chow, Harvey Y.S. Chan, Maggie Zi Ying Chow, Ioannis Karakikes, Chong Fai Mok, Andrew L. Miller, Sarah E. Webb, Ronald A. Li, Anskar Y.H. Leung, Lin Geng, Lihuan Ren, Camie W. Chan, Roger J. Hajjar, Chi-Wing Kong, Wendy Keung

Publikováno v: Stem Cells and Development. 23:1704-1716

Self-renewable human pluripotent stem cells (hPSCs) serve as a potential unlimited ex vivo source of human cardiomyocytes (CMs) for cell-based disease modeling and therapies. Although recent advances in directed differentiation protocols have enabled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c39544225a798941477ef900e2a8aa6
https://doi.org/10.1089/scd.2013.0509

Controlled physiomimetic preload augments inotropic sensitivity and contractile phenotypes in human pluripotent stem cell-derived engineered cardiac tissues and chambers

Autor: Ronald A. Li, Andy O.-T. Wong, Camie W. Chan, Kevin D. Costa

Publikováno v: Journal of Pharmacological and Toxicological Methods. 99:106595

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dee789c9312d6772e92b6d0b640025c7
https://doi.org/10.1016/j.vascn.2019.05.179