Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Cameron W, Brennan"'
Autor:
Douglas A. Mata, Jamal K. Benhamida, Andrew L. Lin, Chad M. Vanderbilt, Soo-Ryum Yang, Liliana B. Villafania, Donna C. Ferguson, Philip Jonsson, Alexandra M. Miller, Viviane Tabar, Cameron W. Brennan, Nelson S. Moss, Martin Sill, Ryma Benayed, Ingo K. Mellinghoff, Marc K. Rosenblum, Maria E. Arcila, Marc Ladanyi, Tejus A. Bale
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract A subset of glioblastomas (GBMs) harbors potentially druggable oncogenic FGFR3-TACC3 (F3T3) fusions. However, their associated molecular and clinical features are poorly understood. Here we analyze the frequency of F3T3-fusion positivity, it
Externí odkaz:
https://doaj.org/article/e6a9da3b0b01489295be630dcbaceb95
Autor:
Sarin Kitpanit, Anna Lee, Ken L. Pitter, Dan Fan, James C.H. Chow, Brian Neal, Zhiqiang Han, Pamela Fox, Kevin Sine, Dennis Mah, Lara A. Dunn, Eric J. Sherman, Loren Michel, Ian Ganly, Richard J. Wong, Jay O. Boyle, Marc A. Cohen, Bhuvanesh Singh, Cameron W. Brennan, Igor T. Gavrilovic, Vaios Hatzoglou, Bernard O‘Malley, Kaveh Zakeri, Yao Yu, Linda Chen, DaphnaY. Gelblum, Jung Julie Kang, Sean M. McBride, Chiaojung J. Tsai, Nadeem Riaz, Nancy Y. Lee
Publikováno v:
International Journal of Particle Therapy, Vol 6, Iss 4, Pp 1-12 (2020)
Purpose: To demonstrate temporal lobe necrosis (TLN) rate and clinical/dose-volume factors associated with TLN in radiation-naïve patients with head and neck cancer treated with proton therapy where the field of radiation involved the skull base. Ma
Externí odkaz:
https://doaj.org/article/13629738ba634f5f937500601396273a
Autor:
Luciano Galdieri, Arijita Jash, Olga Malkova, Diane D. Mao, Patrick DeSouza, Yunli E. Chu, Amber Salter, Jian L. Campian, Kristen M. Naegle, Cameron W. Brennan, Hiroaki Wakimoto, Stephen T. Oh, Albert H. Kim, Milan G. Chheda
Publikováno v:
JCI Insight, Vol 6, Iss 4 (2021)
Most patients with glioblastoma (GBM) die within 2 years. A major therapeutic goal is to target GBM stem cells (GSCs), a subpopulation of cells that contribute to treatment resistance and recurrence. Since their discovery in 2003, GSCs have been isol
Externí odkaz:
https://doaj.org/article/3ad4223883d44065a3189bf98ee59bd8
Autor:
George Kokosis, MD, Joshua Vorstenbosch, MD, PhD, Arianna Lombardi, BA, Meghana G. Shamsunder, MPH, Babak Mehrara, MD, Geoffrey E. Hespe, MD, Laura Wang, MD, Cameron W. Brennan, MD, Ian Ganly, MD, PhD, Evan Matros, MD, MMSc, MPH
Publikováno v:
Plastic and Reconstructive Surgery, Global Open, Vol 8, Iss 8, p e2988 (2020)
Summary:. Chronic complications following anterior cranial fossa tumor extirpation, such as cerebrospinal fluid leak, meningitis, mucocele, pneumocephalus, and abscess, negatively impact patient quality of life. Robust vascularized tissue is generall
Externí odkaz:
https://doaj.org/article/666619ef684a47bbac12a10c884e56f6
Autor:
Rajendra P. Pangeni, Zhou Zhang, Angel A. Alvarez, Xuechao Wan, Namratha Sastry, Songjian Lu, Taiping Shi, Tianzhi Huang, Charles X. Lei, C. David James, John A. Kessler, Cameron W. Brennan, Ichiro Nakano, Xinghua Lu, Bo Hu, Wei Zhang, Shi-Yuan Cheng
Publikováno v:
Epigenetics, Vol 13, Iss 4, Pp 432-448 (2018)
Glioma stem cells (GSCs), a subpopulation of tumor cells, contribute to tumor heterogeneity and therapy resistance. Gene expression profiling classified glioblastoma (GBM) and GSCs into four transcriptomically-defined subtypes. Here, we determined th
Externí odkaz:
https://doaj.org/article/9f203d1a69c64cac8045dc5a3fdc5f92
Autor:
Debyani Chakravarty, Alicia M. Pedraza, Jesse Cotari, Angela H. Liu, Diana Punko, Aushim Kokroo, Jason T. Huse, Gregoire Altan-Bonnet, Cameron W. Brennan
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Concurrent amplifications of EGFR and PDGFRA have been reported in up to 5% of glioblastoma (GBM) and it remains unclear why such independent amplification events, and associated receptor overexpression, would be adaptive during glioma evolu
Externí odkaz:
https://doaj.org/article/052b404398294acfaa36d10454862c2e
Autor:
Ioannis Kaffes, Frank Szulzewsky, Zhihong Chen, Cameron J. Herting, Ben Gabanic, José E. Velázquez Vega, Jennifer Shelton, Jeffrey M. Switchenko, James L. Ross, Leon F. McSwain, Jason T. Huse, Bengt Westermark, Sven Nelander, Karin Forsberg-Nilsson, Lene Uhrbom, Naga Prathyusha Maturi, Patrick. J. Cimino, Eric C. Holland, Helmut Kettenmann, Cameron W. Brennan, Daniel J. Brat, Dolores Hambardzumyan
Publikováno v:
OncoImmunology, Vol 8, Iss 11 (2019)
Glioblastoma (GBM) is the most aggressive malignant primary brain tumor in adults, with a median survival of 14.6 months. Recent efforts have focused on identifying clinically relevant subgroups to improve our understanding of pathogenetic mechanisms
Externí odkaz:
https://doaj.org/article/99915def14e347129ecc08b39b7bf014
Autor:
Ramya Raviram, Anugraha Raman, Sebastian Preissl, Jiangfang Ning, Shaoping Wu, Tomoyuki Koga, Kai Zhang, Cameron W. Brennan, Chenxu Zhu, Jens Luebeck, Kinsey Van Deynze, Jee Yun Han, Xiaomeng Hou, Zhen Ye, Anna K. Mischel, Yang Eric Li, Rongxin Fang, Tomas Baback, Joshua Mugford, Claudia Z. Han, Christopher K. Glass, Cathy L. Barr, Paul S. Mischel, Vineet Bafna, Laure Escoubet, Bing Ren, Clark C. Chen
Publikováno v:
Proceedings of the National Academy of Sciences. 120
In 2021, the World Health Organization reclassified glioblastoma, the most common form of adult brain cancer, into isocitrate dehydrogenase (IDH)-wild-type glioblastomas and grade IV IDH mutant (G4 IDHm) astrocytomas. For both tumor types, intratumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cce9c22daadca11e70853ea6f841ad6c
https://doi.org/10.1073/pnas.2210991120
https://doi.org/10.1073/pnas.2210991120
Autor:
Ingo K. Mellinghoff, Lisa M. DeAngelis, Nikolaus Schultz, Thomas G. Graeber, Katherine S. Panageas, Jason T. Huse, Philip H. Gutin, Anne S. Reiner, Vaios Hatzoglou, Enrico C. Lallana, Scott Peak, Jon Glass, Minhee Won, Ahmet Dogan, Julia Wolfe, Craig H. Moskowitz, Craig S. Sauter, Paul Hamlin, M. Lia Palomba, Ariela Noy, Elina Tsyvkin, Alissa A. Thomas, Elena Pentsova, Antonio Omuro, Craig P. Nolan, Thomas J. Kaley, Igor T. Gavrilovic, Cameron W. Brennan, Viviane S. Tabar, Agnes Viale, Marc Rosenblum, Dan Rohle, Wan-Ying Hsieh, Owen Clark, Donna Nichol, Paolo Codega, Derrek Schartz, Carl Campos, Sarah S. Tang, Nicolaos Palaskas, Alessandro Pastore, Christian Grommes
Supplementary Methods. Supplementary Table S1: Baseline characteristics of PCNSL Patients. Supplementary Table S2: Baseline characteristics of SCNSL patients. Supplementary Table S3: Corticosteroid use. Supplementary Table S4: Genes with Recurrent Mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846702464e3ab3c289e6186006db05bc
https://doi.org/10.1158/2159-8290.22532099
https://doi.org/10.1158/2159-8290.22532099
Autor:
Ingo K. Mellinghoff, Timothy F. Cloughesy, Minesh P. Mehta, Paul S. Mischel, John G. Kuhn, William H. Yong, Lisa M. DeAngelis, Andrew B. Lassman, Nian Wu, Steve Horvath, Howard A. Fine, Michael D. Prados, Susan M. Chang, Kathleen R. Lamborn, Patrick Y. Wen, Jan Drappatz, David A. Reardon, Mark R. Gilbert, W. K. Alfred Yung, Frank Lieberman, Linda M. Liau, Adriana Heguy, Cameron W. Brennan, Alicia Pedraza, Julie Dang, Daisuke Kuga, Akio Iwanami, Shaojun Zhu, Hui Tao, Nicolas Yannuzzi, Milan G. Chheda, Barbara Oldrini, Sara Kubek, Phioanh Leia Nghiemphu, Christian Grommes, Carl Campos, Daniel Rohle, H. Ian Robins, Igor Vivanco
mp3 file (11 MB). In the May edition of the Cancer Discovery podcast, Science Writer Elizabeth McKenna talks with Ingo K. Mellinghoff about his paper, which suggests that the disappointing clinical activity of first-generation EGFR inhibitors in glio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ea84dde1575a2f19855b3499939fbe
https://doi.org/10.1158/2159-8290.22529031.v1
https://doi.org/10.1158/2159-8290.22529031.v1