Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Cameron Torcassi"'
Autor:
Yuji Tanaka, Shuichi Igarashi, Masayuki Nakamura, Juliette Gafni, Cameron Torcassi, Gabrielle Schilling, Danielle Crippen, Jonathan D. Wood, Akira Sawa, Nancy A. Jenkins, Neal G. Copeland, David R. Borchelt, Christopher A. Ross, Lisa M. Ellerby
Publikováno v:
Neurobiology of Disease, Vol 21, Iss 2, Pp 381-391 (2006)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized behaviorally by chorea, incoordination, and shortened lifespan and neuropathologically by huntingtin inclusions and neuronal degeneration. In order to facilit
Externí odkaz:
https://doaj.org/article/0f583253bf4e44ac933ae12f542f61b9
Autor:
John P Miller, Bridget E Yates, Ismael Al-Ramahi, Ari E Berman, Mario Sanhueza, Eugene Kim, Maria de Haro, Francesco DeGiacomo, Cameron Torcassi, Jennifer Holcomb, Juliette Gafni, Sean D Mooney, Juan Botas, Lisa M Ellerby, Robert E Hughes
Publikováno v:
PLoS Genetics, Vol 8, Iss 11, p e1003042 (2012)
A genome-scale RNAi screen was performed in a mammalian cell-based assay to identify modifiers of mutant huntingtin toxicity. Ontology analysis of suppressor data identified processes previously implicated in Huntington's disease, including proteolys
Externí odkaz:
https://doaj.org/article/175b1e0ba3254567b62e13171c7342da
Autor:
Linda S Kaltenbach, Eliana Romero, Robert R Becklin, Rakesh Chettier, Russell Bell, Amit Phansalkar, Andrew Strand, Cameron Torcassi, Justin Savage, Anthony Hurlburt, Guang-Ho Cha, Lubna Ukani, Cindy Lou Chepanoske, Yuejun Zhen, Sudhir Sahasrabudhe, James Olson, Cornelia Kurschner, Lisa M Ellerby, John M Peltier, Juan Botas, Robert E Hughes
Publikováno v:
PLoS Genetics, Vol 3, Iss 5, p e82 (2007)
Huntington's disease (HD) is a fatal neurodegenerative condition caused by expansion of the polyglutamine tract in the huntingtin (Htt) protein. Neuronal toxicity in HD is thought to be, at least in part, a consequence of protein interactions involvi
Externí odkaz:
https://doaj.org/article/13bd083a8da44dd192d10530abf31c3c
Autor:
Michelle A. LaFevre-Bernt, Lisa M. Ellerby, Juliette Gafni, Birgit Schilling, Richard H. Row, Cameron Torcassi, Ricky R. Hirschhorn, Xin Cong, Bradford W. Gibson, Michael P. Cusack, Tamara Ratovitski, Christopher A. Ross
Publikováno v:
Journal of Biological Chemistry. 281:23686-23697
Huntingtin (Htt) is a large protein of 3144 amino acids, whose function and regulation have not been well defined. Polyglutamine (polyQ) expansion in the N terminus of Htt causes the neurodegenerative disorder Huntington disease (HD). The cytotoxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dbd964f8c1c59e812f5fed877c90b1e
https://doi.org/10.1074/jbc.m513507200
https://doi.org/10.1074/jbc.m513507200
Autor:
Sean D. Mooney, John P. Miller, Lisa M. Ellerby, Ari E. Berman, Francesco DeGiacomo, Jennifer Holcomb, Juliette Gafni, Eugene Kim, Cameron Torcassi, Juan Botas, Ismael Al-Ramahi, Maria de Haro, Mario Sanhueza, Bridget Yates, Robert E. Hughes
Publikováno v:
PLoS Genetics, Vol 8, Iss 11, p e1003042 (2012)
PLoS Genetics
PLoS Genetics
A genome-scale RNAi screen was performed in a mammalian cell-based assay to identify modifiers of mutant huntingtin toxicity. Ontology analysis of suppressor data identified processes previously implicated in Huntington's disease, including proteolys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b47db2fe78f6c12fb08b31b730b1f8
http://europepmc.org/articles/PMC3510027?pdf=render
http://europepmc.org/articles/PMC3510027?pdf=render
Autor:
Birgit, Schilling, Juliette, Gafni, Cameron, Torcassi, Xin, Cong, Richard H, Row, Michelle A, LaFevre-Bernt, Michael P, Cusack, Tamara, Ratovitski, Ricky, Hirschhorn, Christopher A, Ross, Bradford W, Gibson, Lisa M, Ellerby
Publikováno v:
The Journal of biological chemistry. 281(33)
Huntingtin (Htt) is a large protein of 3144 amino acids, whose function and regulation have not been well defined. Polyglutamine (polyQ) expansion in the N terminus of Htt causes the neurodegenerative disorder Huntington disease (HD). The cytotoxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f44d344ae585461b787d6163d43c7cf6
https://pubmed.ncbi.nlm.nih.gov/16782707
https://pubmed.ncbi.nlm.nih.gov/16782707
Autor:
Yuji Tanaka, Nancy A. Jenkins, Danielle Crippen, David R. Borchelt, Juliette Gafni, Cameron Torcassi, Jonathan D. Wood, Gabrielle Schilling, Neal G. Copeland, Lisa M. Ellerby, Christopher A. Ross, Masayuki Nakamura, Shuichi Igarashi, Akira Sawa
Publikováno v:
Neurobiology of Disease, Vol 21, Iss 2, Pp 381-391 (2006)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized behaviorally by chorea, incoordination, and shortened lifespan and neuropathologically by huntingtin inclusions and neuronal degeneration. In order to facilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa19927f2c760f99bf7b5654b4d0903
https://pubmed.ncbi.nlm.nih.gov/16150600
https://pubmed.ncbi.nlm.nih.gov/16150600
Autor:
Sudhir Sahasrabudhe, Cornelia Kurschner, Robert E. Hughes, Amit Phansalkar, Linda S. Kaltenbach, Robert R. Becklin, Eliana Romero, Rakesh Chettier, Juan Botas, Lubna Ukani, Russell Bell, Anthony Hurlburt, Cameron Torcassi, Yuejun Zhen, John M. Peltier, James M. Olson, Justin Savage, Cindy Lou Chepanoske, Lisa M. Ellerby, Guang Ho Cha, Andrew D. Strand
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 3, Iss 5, p e82 (2007)
PLoS Genetics, Vol 3, Iss 5, p e82 (2007)
Huntington's disease (HD) is a fatal neurodegenerative condition caused by expansion of the polyglutamine tract in the huntingtin (Htt) protein. Neuronal toxicity in HD is thought to be, at least in part, a consequence of protein interactions involvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94d19b9bf2cecb2f2f040f79c491504
https://doi.org/10.1371/journal.pgen.0030082
https://doi.org/10.1371/journal.pgen.0030082
Autor:
Lisa M. Ellerby, John P. Miller, Juliette Gafni, Seung Kwak, Juan Botas, Ismael Al-Ramahi, Jennifer Holcomb, Mario Sanhueza, Maria de Haro, Ningzhe Zhang, Eugene Kim, Cameron Torcassi, Robert E. Hughes
Publikováno v:
Neuron. (2):199-212
Summary Proteolytic cleavage of huntingtin (Htt) is known to be a key event in the pathogenesis of Huntington's disease (HD). Our understanding of proteolytic processing of Htt has thus far focused on the protease families — caspases and calpains.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe22e49c80b6797790c5fb0f7ac3709