Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Cameron Stuver Moody"'
Autor:
Xavier Carette, John Platig, David C. Young, Michaela Helmel, Albert T. Young, Zhe Wang, Lakshmi-Prasad Potluri, Cameron Stuver Moody, Jumei Zeng, Sladjana Prisic, Joseph N. Paulson, Jan Muntel, Ashoka V. R. Madduri, Jorge Velarde, Jacob A. Mayfield, Christopher Locher, Tiansheng Wang, John Quackenbush, Kyu Y. Rhee, D. Branch Moody, Hanno Steen, Robert N. Husson
Publikováno v:
mBio, Vol 9, Iss 2 (2018)
ABSTRACT Tuberculosis is the leading killer among infectious diseases worldwide. Increasing multidrug resistance has prompted new approaches for tuberculosis drug development, including targeted inhibition of virulence determinants and of signaling c
Externí odkaz:
https://doaj.org/article/499cf436426a467c922809513e71e00a
Autor:
William P. Taylor, Mark Edward Bunnage, Hardwin O'dowd, Michael P. Clark, Dan Crawford, Sanjay Shivayogi Magavi, Bin Song, Jianglin Liang, Timothy J. Senter, Tal Kramer, Juntyma J. Engtrakul, Arun K. Mohanty, Fan Lu, Hong Gao, Yulin Huang, Swett Rebecca Jane, Bryan W. Vought, Ray Winquist, Tony Considine, Ganesh Iyer, Kenneth C. Bonanno, Elisabeth Doyle, Suganthini Nanthakumar, Raymond Kemper, Elaine Krueger, Cameron Stuver Moody, Joyce T. Coll, Paul S. Charifson, John J. Court, Wenxin Gu, Francois Maltais, Gale-Day Zachary, Ananthisrinivas Chakilam, Jon H. Come, John L. Andreassi, Morris Mark A, Brinley Furey, Christina Boucher, Martin Sanders, Harmon J. Zuccola, Gagnon Kevin James, Katrina L. Jackson, Lu Gan, Jonathan A. Phillips
Publikováno v:
Journal of Medicinal Chemistry. 64:17753-17776
Accumulation of very long chain fatty acids (VLCFAs) due to defects in ATP binding cassette protein D1 (ABCD1) is thought to underlie the pathologies observed in adrenoleukodystrophy (ALD). Pursuing a substrate reduction approach based on the inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df83528af04585e5c3ec98c9649f09d
https://doi.org/10.1021/acs.jmedchem.1c00944
https://doi.org/10.1021/acs.jmedchem.1c00944
Autor:
Pan Li, Alex Aronov, Jianglin Liang, Kira Mcginty, Waal Nathan D, Cameron Stuver Moody, Swett Rebecca Jane, Pamella J. Ford, Qing Tang, David D. Deininger, Simon Giroux, Diane M. Boucher, Steven M. Ronkin, Lauffer David J
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein, we report a novel series of highly potent and selective triazolothiadiazole c-Met inhibitors. Starting with molecule 5, we have applied structure-based drug design principles to identify the triazolothiadiazole ring system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224c37b505a53218d1599fe4fc01cb38
https://europepmc.org/articles/PMC8201751/
https://europepmc.org/articles/PMC8201751/
Autor:
Simon Giroux, Jon H. Come, Robert J. Davies, Upul K. Bandarage, Alex Aronov, David Messersmith, Cameron Stuver Moody, Swett Rebecca Jane, Sudipta Mahajan, Kevin M. Cottrell, Jingrong Cao, Marc Jacobs, Jinwang Xu
Publikováno v:
ACS Med Chem Lett
[Image: see text] Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that control a wide variety of cellular functions such as cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking. PI3Kγ plays a crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdfb951ef4716045f64335b0bfb49625
https://pubmed.ncbi.nlm.nih.gov/33488974
https://pubmed.ncbi.nlm.nih.gov/33488974
Autor:
Jianglin Liang, Robert J. Davies, James P. Griffith, Hardwin O'dowd, Cameron Stuver Moody, Elaine Krueger, Philip N. Collier, Yusheng Liao, Upul K. Bandarage, Alex Aronov, Jian Wang, Jingrong Cao, Derek B. Lowe, Veronique Damagnez, Elaine Y. Chin, John D. Doran, Emmanuelle Sizensky, Wojciech Dworakowski, Sudipta Mahajan, David D. Deininger, Marc Jacobs, Jinwang Xu, Arnaud Le Tiran, Suvarna Khare-Pandit, Albert C. Pierce, Suganthi Nanthakumar, Ron Grey, David Messersmith, James A. Henderson, Jon H. Come
Publikováno v:
Journal of Medicinal Chemistry. 61:5245-5256
The lipid kinase phosphoinositide 3-kinase γ (PI3Kγ) has attracted attention as a potential target to treat a variety of autoimmune disorders, including multiple sclerosis, due to its role in immune modulation and microglial activation. By minimizi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd9109c79e1ecbf0788c161384fe50c
https://doi.org/10.1021/acs.jmedchem.8b00085
https://doi.org/10.1021/acs.jmedchem.8b00085
Autor:
David Messersmith, Cameron Stuver Moody, Sudipta Mahajan, Yusheng Liao, Upul K. Bandarage, Jinwang Xu, Tiansheng Wang, James P. Griffith, Arnaud Le Tiran, Veronique Damagnez, Elaine Krueger, Setu Roday, Jon H. Come, Kevin M. Cottrell, Brian Ledford, Philip N. Collier, Alex Aronov, Mark W. Ledeboer, Suvarna Khare-Pandit, John D. Doran, Christina Boucher
Publikováno v:
Journal of Medicinal Chemistry. 58:5684-5688
A series of high affinity second-generation thiazolopiperidine inhibitors of PI3Kγ were designed based on some general observations around lipid kinase structure. Optimization of the alkylimidazole group led to inhibitors with higher levels of PI3K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a182fa6e1c15f5980023fc31188413a5
https://doi.org/10.1021/acs.jmedchem.5b00498
https://doi.org/10.1021/acs.jmedchem.5b00498
Autor:
Youssef L. Bennani, Brian L. Hanzelka, Tiansheng Wang, Guy W. Bemis, Yuzhou Xu, Hongwu Gao, Harmon J. Zuccola, Christopher Locher, Ute Müh, Aixiang Liu, Jeremy Green, John A. Thomson, Michael Wynn, Cameron Stuver Moody, Shaohui Wang, Jie Wang
Drug resistant tuberculosis (TB) infections are on the rise and antibiotics that inhibit Mycobacterium tuberculosis through a novel mechanism could be an important component of evolving TB therapy. Protein kinase A (PknA) and protein kinase B (PknB)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbd8feef2c91be44426fa4553879953
https://europepmc.org/articles/PMC5733270/
https://europepmc.org/articles/PMC5733270/
Autor:
Alex Aronov, Gabriel Martinez-Botella, John D. Doran, Cameron Stuver Moody, Philip N. Collier, Tiansheng Wang, Mark Cornebise, Emilie Porter Huck, James P. Griffith, Francois Maltais, Sudipta Mahajan, Kevin M. Cottrell
Publikováno v:
Journal of Medicinal Chemistry. 58:517-521
Phosphoinositide 3-kinase γ (PI3Kγ) is an attractive target to potentially treat a range of disease states. Herein, we describe the evolution of a reported phenylthiazole pan-PI3K inhibitor into a family of potent and selective benzothiazole inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c859fb78043a075999335a5e53664f
https://doi.org/10.1021/jm500362j
https://doi.org/10.1021/jm500362j
Autor:
Cameron Stuver Moody, Christian H. Gross, Kennedy Joseph M, Paul S. Charifson, Emanuele Perola, Leonard R. Duncan, Tiansheng Wang, Wenxin Gu, Jeremy Green, Yunyi Wei, S J Ryan Arends, Brian Ledford, Jonathan D. Parsons, Francois Maltais
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3693-3698
A series of 2,6-disubstituted aminoalkoxypyrimidine carboxamides (AAPCs) with potent inhibition of bacterial NAD(+)-dependent DNA ligase was discovered through the use of structure-guided design. Two subsites in the NAD(+)-binding pocket were explore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18eec8bd767ac43291b2578e5724083
https://doi.org/10.1016/j.bmcl.2012.04.037
https://doi.org/10.1016/j.bmcl.2012.04.037
Autor:
Cameron Stuver Moody, Vladimir Savic, Guy W. Bemis, Upul K. Bandarage, Qing Tang, Christopher S. Adams, Emmanuelle Charonnet, Jonathan D. Parsons, Craig Marhefka, Sundeep Shah, Jose Bravo, Jeremy Green, Brian Hare, Ly Pham, Steve Rodems, Jon H. Come
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5191-5194
We report herein the design and synthesis of 4-(benzimidazol-2-yl)-1,2,5-oxadiazol-3-amine derivatives as inhibitors of p70S6 kinase. Screening hits containing the 4-(benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine scaffold were optimized for p70S6K pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6823637b48cb3d4493233dacb007263e
https://doi.org/10.1016/j.bmcl.2009.07.022
https://doi.org/10.1016/j.bmcl.2009.07.022