Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Cameron S. Osborne"'
Autor:
William Villiers, Audrey Kelly, Xiaohan He, James Kaufman-Cook, Abdurrahman Elbasir, Halima Bensmail, Paul Lavender, Richard Dillon, Borbála Mifsud, Cameron S. Osborne
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
The PML-RARA gene fusion is the characteristic driver of Acute Promyelocytic Leukaemia (APL) and is known to bind to the genome. Here, the authors characterise the impact of PML-RARA on gene regulation in APL cell lines and patient samples using tran
Externí odkaz:
https://doaj.org/article/e21c11aeb3a5412fa736e7db9112d5f6
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
It is now evident that DNA forms an organized nuclear architecture, which is essential to maintain the structural and functional integrity of the genome. Chromatin organization can be systematically studied due to the recent boom in chromosome confor
Externí odkaz:
https://doaj.org/article/d1ad71cf7669483b8d1d39704bb01462
Autor:
Anetta Ptasinska, Anna Pickin, Salam A. Assi, Paulynn Suyin Chin, Luke Ames, Roberto Avellino, Stephan Gröschel, Ruud Delwel, Peter N. Cockerill, Cameron S. Osborne, Constanze Bonifer
Publikováno v:
Cell Reports, Vol 28, Iss 12, Pp 3022-3031.e7 (2019)
Summary: Acute myeloid leukemia (AML) is associated with mutations in transcriptional and epigenetic regulator genes impairing myeloid differentiation. The t(8;21)(q22;q22) translocation generates the RUNX1-ETO fusion protein, which interferes with t
Externí odkaz:
https://doaj.org/article/2b0d62787baa4241a7c8f172ae5a28e0
Autor:
Oliver M. Dovey, Pedro Madrigal, Paolo Gallipoli, George S. Vassiliou, Haiyang Yun, Cameron S. Osborne, Shuchi Agrawal-Singh, Annalisa Mupo, Shabana Vohra, David Lara-Astiaso, Aracely Castillo-Venzor, Faisal Basheer, Sarah J. Horton, Brian J. P. Huntly, Ludovica Marando, Malgorzata Gozdecka, Eshwar Meduri, Carsten Müller-Tidow, Daniel Sasca, George Giotopoulos, Xiaonan Wang, Nisha Narayan
Publikováno v:
Nature Genetics. 53:1443-1455
Altered transcription is a cardinal feature of acute myeloid leukemia (AML); however, exactly how mutations synergize to remodel the epigenetic landscape and rewire three-dimensional DNA topology is unknown. Here, we apply an integrated genomic appro
Autor:
Paula Freire-Pritchett, Stefan Schoenfelder, Csilla Várnai, Steven W Wingett, Jonathan Cairns, Amanda J Collier, Raquel García-Vílchez, Mayra Furlan-Magaril, Cameron S Osborne, Peter Fraser, Peter J Rugg-Gunn, Mikhail Spivakov
Publikováno v:
eLife, Vol 6 (2017)
Long-range cis-regulatory elements such as enhancers coordinate cell-specific transcriptional programmes by engaging in DNA looping interactions with target promoters. Deciphering the interplay between the promoter connectivity and activity of cis-re
Externí odkaz:
https://doaj.org/article/6b57a130ecbc478aaa570feb12bd03e6
Autor:
C David Wood, Hildegonda Veenstra, Sarika Khasnis, Andrea Gunnell, Helen M Webb, Claire Shannon-Lowe, Simon Andrews, Cameron S Osborne, Michelle J West
Publikováno v:
eLife, Vol 5 (2016)
Lymphomagenesis in the presence of deregulated MYC requires suppression of MYC-driven apoptosis, often through downregulation of the pro-apoptotic BCL2L11 gene (Bim). Transcription factors (EBNAs) encoded by the lymphoma-associated Epstein-Barr virus
Externí odkaz:
https://doaj.org/article/d0168bf945bb4d54b7a76064f2dbc58e
Autor:
Abdurrahman Elbasir, Audrey Kelly, Borbala Mifsud, Cameron S. Osborne, Richard Dillon, Halima Bensmail, Paul Lavender, Xiaohan He, William Villiers
Publikováno v:
SSRN Electronic Journal.
The PML-RARA fusion protein is the hallmark driver of Acute Promyelocytic Leukemia (APL) and disrupts retinoic acid signaling, leading to wide-scale gene expression changes and uncontrolled proliferation of myeloid precursor cells. While known to be
Autor:
George Giotopoulos, Shabana Vohra, Carsten Müller-Tidow, Faisal Basheer, Annalisa Mupo, Daniel Sasca, Paolo Gallipoli, Eshwar Meduri, Sarah J. Horton, Ludovica Marando, Malgorzata Gozdecka, Oliver M. Dovey, Xiaonan Wang, George S. Vassiliou, Shuchi Agrawal-Singh, Cameron S. Osborne, Aracely Castillo-Venzor, Brian J. P. Huntly, Haiyang Yun
Altered transcription is a cardinal feature of acute myeloid leukemia (AML), however, exactly how mutations synergize to remodel the epigenetic landscape and rewire 3-Dimensional (3-D) DNA topology is unknown. Here we apply an integrated genomic appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c296f929ce2ad4d8f3c2ad117276b1a
https://doi.org/10.1101/2020.03.20.000059
https://doi.org/10.1101/2020.03.20.000059
Autor:
Sara E. Dobbins, Cameron S. Osborne, Jussi Taipale, Giulia Orlando, Richard S. Houlston, Philip J. Law, Tomi Pastinen, Kevin Litchfield, Alex J. Cornish, Daniel Chubb, Peter Broderick, Fadi Hariri
Publikováno v:
Nature Genetics. 50:1375-1380
Efforts are being directed to systematically analyze the non-coding regions of the genome for cancer-driving mutations1-6. cis-regulatory elements (CREs) represent a highly enriched subset of the non-coding regions of the genome in which to search fo
Autor:
Beatriz Goyenechea, Ryan C. Pink, Daniel Paul Caley, Cameron S. Osborne, Alice Horton, Yan-Feng Dai, Peter Fraser, Sandra Dye, Susanna Harju-Baker, Joanne Miles, David R. F. Carter, Lyubomira Chakalova, Kenneth R. Peterson, Emmanuel Debrand
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0217532 (2019)
PLoS ONE
PLoS ONE
Transcriptome analyses show a surprisingly large proportion of the mammalian genome is transcribed; much more than can be accounted for by genes and introns alone. Most of this transcription is non-coding in nature and arises from intergenic regions,