Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Cameron S. Cowan"'
Autor:
Anthony M. Musolf, Annechien E. G. Haarman, Robert N. Luben, Jue-Sheng Ong, Karina Patasova, Rolando Hernandez Trapero, Joseph Marsh, Ishika Jain, Riya Jain, Paul Zhiping Wang, Deyana D. Lewis, Milly S. Tedja, Adriana I. Iglesias, Hengtong Li, Cameron S. Cowan, Consortium for Refractive Error and Myopia (CREAM), Ginevra Biino, Alison P. Klein, Priya Duggal, David A. Mackey, Caroline Hayward, Toomas Haller, Andres Metspalu, Juho Wedenoja, Olavi Pärssinen, Ching-Yu Cheng, Seang-Mei Saw, Dwight Stambolian, Pirro G. Hysi, Anthony P. Khawaja, Veronique Vitart, Christopher J. Hammond, Cornelia M. van Duijn, Virginie J. M. Verhoeven, Caroline C. W. Klaver, Joan E. Bailey-Wilson
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
A multi-ethnic meta-analysis of exome array data from over 27,000 participants identifies several rare variants that could contribute to risk of ocular refractive error.
Externí odkaz:
https://doaj.org/article/bd8c4caa72a641eab1075fd26afb62da
Autor:
Philipp Wahle, Giovanna Brancati, Christoph Harmel, Zhisong He, Gabriele Gut, Jacobo Sarabia del Castillo, Aline Xavier da Silveira dos Santos, Qianhui Yu, Pascal Noser, Jonas Simon Fleck, Bruno Gjeta, Dinko Pavlinić, Simone Picelli, Max Hess, Gregor W. Schmidt, Tom T. A. Lummen, Yanyan Hou, Patricia Galliker, David Goldblum, Marton Balogh, Cameron S. Cowan, Hendrik P. N. Scholl, Botond Roska, Magdalena Renner, Lucas Pelkmans, Barbara Treutlein, J. Gray Camp
Publikováno v:
Nature Biotechnology
Organoids generated from human pluripotent stem cells provide experimental systems to study development and disease, but quantitative measurements across different spatial scales and molecular modalities are lacking. In this study, we generated multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3227d55e7047c525b975cb734a1f2a68
https://doi.org/10.1038/s41587-023-01747-2
https://doi.org/10.1038/s41587-023-01747-2
Autor:
Alissa Muller, Jack Sullivan, Wibke Schwarzer, Mantian Wang, Cindy Park-Windhol, Beryll Klingler, Jane Matsell, Simon Hostettler, Patricia Galliker, Mert Duman, Yanyan Hou, Pierre Balmer, Tamás Virág, Luis Alberto Barrera, Quan Xu, Dániel Péter Magda, Ferenc Kilin, Arogya Khadka, Mathieu Quinodoz, Pascal W. Hasler, Pierre-Henri Moreau, Lyne Fellmann, Thierry Azoulay, Marco Cattaneo, Simone Picelli, Alice Grison, Cameron S. Cowan, Lucas Janeschitz-Kriegl, Ákos Kusnyerik, Magdalena Renner, Zoltán Zsolt Nagy, Arnold Szabó, Carlo Rivolta, Hendrik P.N. Scholl, David Bryson, Giuseppe Ciaramella, Botond Roska, Bence György
Stargardt disease is a currently untreatable, inherited neurodegenerative disease that leads to macular degeneration and blindness due to loss-of-function mutations in theABCA4gene. We have designed a dual adeno-associated viral vector split-intein a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd497ac7466dc48e5713f90aa2177981
https://doi.org/10.1101/2023.04.17.535579
https://doi.org/10.1101/2023.04.17.535579
Autor:
Martin Munz, Arjun Bharioke, Georg Kosche, Verónica Moreno-Juan, Alexandra Brignall, Alexandra Graff-Meyer, Talia Ulmer, Tiago M. Rodrigues, Stephanie Haeuselmann, Dinko Pavlinic, Nicole Ledergeber, Brigitte Gross-Scherf, Balázs Rózsa, Jacek Krol, Simone Picelli, Cameron S. Cowan, Botond Roska
SummaryCortical circuits are composed predominantly of pyramidal-to-pyramidal neuron connections, yet their assembly during embryonic development is not well understood. We show that embryonic layer 5 pyramidal neurons, identified through single cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cff10fd6d26329121c189b3709769648
https://doi.org/10.1101/2022.08.31.506080
https://doi.org/10.1101/2022.08.31.506080
Autor:
Martin Munz, Arjun Bharioke, Georg Kosche, Verónica Moreno-Juan, Alexandra Brignall, Tiago M. Rodrigues, Alexandra Graff-Meyer, Talia Ulmer, Stephanie Haeuselmann, Dinko Pavlinic, Nicole Ledergerber, Brigitte Gross-Scherf, Balázs Rózsa, Jacek Krol, Simone Picelli, Cameron S. Cowan, Botond Roska
Publikováno v:
Cell. 186:1930-1949.e31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::810283334a44c4e6a85ddee62d009b6f
https://doi.org/10.1016/j.cell.2023.03.025
https://doi.org/10.1016/j.cell.2023.03.025
In the last 10 years, single-cell RNA-sequencing (scRNA-seq) has undergone exponential growth. Emulsion droplets methods1–3, such as those commercialized by 10x Genomics, have allowed researchers to analyze tens of thousands of cells in parallel in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1beda724ab05c6b3228d7052dc6f44
https://doi.org/10.1101/2021.07.14.452217
https://doi.org/10.1101/2021.07.14.452217
Autor:
Vincent Hahaut, Dinko Pavlinic, Walter Carbone, Sven Schuierer, Pierre Balmer, Mathieu Quinodoz, Magdalena Renner, Guglielmo Roma, Cameron S. Cowan, Simone Picelli
Publikováno v:
Nature biotechnology. 40(10)
We present FLASH-seq (FS), a full-length single-cell RNA sequencing (scRNA-seq) method with increased sensitivity and reduced hands-on time compared to Smart-seq3. The entire FS protocol can be performed in ~4.5 hours, is simple to automate and can b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6e7a99dd9d15c1101e3f8e75168697
https://pubmed.ncbi.nlm.nih.gov/35637419
https://pubmed.ncbi.nlm.nih.gov/35637419
Autor:
Daniel J. Müller, Karl-Klaus Conzelmann, Aaron Ponti, Martin Munz, Rajib Schubert, Georg Kosche, Cameron S. Cowan, Kamill Balint, Alexander Ghanem, Richard Newton, Keisuke Yonehara, Adrian Wertz, Gotthold Fläschner, Jacek Krol, Brigitte Gross Scherf, Manuel A. Mohr, Daniel Hillier, David Martinez-Martin, Botond Roska, Stuart Trenholm
Publikováno v:
Nature Biotechnology, 36 (1)
Schubert, R, Trenholm, S, Balint, K, Kosche, G, Cowan, C S, Mohr, M A, Munz, M, Martinez-Martin, D, Fläschner, G, Newton, R, Krol, J, Scherf, B G, Yonehara, K, Wertz, A, Ponti, A, Ghanem, A, Hillier, D, Conzelmann, K K, Müller, D J & Roska, B 2018, ' Virus stamping for targeted single-cell infection in vitro and in vivo ', Nature Biotechnology, vol. 36, no. 1, pp. 81-88 . https://doi.org/10.1038/nbt.4034
Nature Biotechnology
Schubert, R, Trenholm, S, Balint, K, Kosche, G, Cowan, C S, Mohr, M A, Munz, M, Martinez-Martin, D, Fläschner, G, Newton, R, Krol, J, Scherf, B G, Yonehara, K, Wertz, A, Ponti, A, Ghanem, A, Hillier, D, Conzelmann, K K, Müller, D J & Roska, B 2018, ' Virus stamping for targeted single-cell infection in vitro and in vivo ', Nature Biotechnology, vol. 36, no. 1, pp. 81-88 . https://doi.org/10.1038/nbt.4034
Nature Biotechnology
Genetic engineering by viral infection of single cells is useful to study complex systems such as the brain. However, available methods for infecting single cells have drawbacks that limit their applications. Here we describe 'virus stamping', in whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8025febcc22a92a42b95f0d43b55c91
https://doi.org/10.1038/nbt.4034
https://doi.org/10.1038/nbt.4034
Autor:
Rei K. Morikawa, Dasha Nelidova, Arnold Szabo, Botond Roska, Hendrik P. N. Scholl, Daniel Hillier, Cameron S. Cowan, Tamas Szikra, Zoltan Raics, David Goldblum
Publikováno v:
Science
Making blind retinas see again Photoreceptor degeneration is an important cause of blindness. Nelidova et al. used tunable, near-infrared sensors to render diseased photoreceptors light sensitive again (see the Perspective by Franke and Vlasits). Gol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6fed67e7c16ce457adb900fd4a779f7
https://pubmed.ncbi.nlm.nih.gov/32499428
https://pubmed.ncbi.nlm.nih.gov/32499428
Autor:
Arnold Szabo, Riccardo Panero, Rachel Cuttat, Simone Picelli, Pascal W. Hasler, Panagiotis Papasaikas, Cameron S. Cowan, Magdalena Renner, Roland Diggelmann, Akos Kusnyerik, Dinko Pavlinic, Florian Nigsch, Andreas Hierlemann, Botond Roska, Yanyan Hou, Tiago M. Rodrigues, Márton Balogh, Annick Waldt, Guglielmo Roma, Jacek Krol, Nadine Gerber-Hollbach, Hendrik P. N. Scholl, Patricia Galliker, Aldin Srdanovic, Michael B. Stadler, David Goldblum, Tamas Szikra, Stefan E. Spirig, Brigitte Gross-Scherf, Martin Munz, Sven Schuierer, Martina De Gennaro, Claudia P. Patino-Alvarez, Selim Orgül
Publikováno v:
Cell
Cell, 182 (6)
Cell, 182 (6)
Summary Human organoids recapitulating the cell-type diversity and function of their target organ are valuable for basic and translational research. We developed light-sensitive human retinal organoids with multiple nuclear and synaptic layers and fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca36b60371a7ce7a3293aa2be695333e
https://pubmed.ncbi.nlm.nih.gov/32946783
https://pubmed.ncbi.nlm.nih.gov/32946783