Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Cameron S Osborne"'
Autor:
Emmanuel Debrand, Lyubomira Chakalova, Joanne Miles, Yan-Feng Dai, Beatriz Goyenechea, Sandra Dye, Cameron S Osborne, Alice Horton, Susanna Harju-Baker, Ryan C Pink, Daniel Caley, David R F Carter, Kenneth R Peterson, Peter Fraser
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0217532 (2019)
Transcriptome analyses show a surprisingly large proportion of the mammalian genome is transcribed; much more than can be accounted for by genes and introns alone. Most of this transcription is non-coding in nature and arises from intergenic regions,
Externí odkaz:
https://doaj.org/article/f760b86557e64c7aa9603fb04830e930
Autor:
Paula Freire-Pritchett, Stefan Schoenfelder, Csilla Várnai, Steven W Wingett, Jonathan Cairns, Amanda J Collier, Raquel García-Vílchez, Mayra Furlan-Magaril, Cameron S Osborne, Peter Fraser, Peter J Rugg-Gunn, Mikhail Spivakov
Publikováno v:
eLife, Vol 6 (2017)
Long-range cis-regulatory elements such as enhancers coordinate cell-specific transcriptional programmes by engaging in DNA looping interactions with target promoters. Deciphering the interplay between the promoter connectivity and activity of cis-re
Externí odkaz:
https://doaj.org/article/6b57a130ecbc478aaa570feb12bd03e6
Autor:
C David Wood, Hildegonda Veenstra, Sarika Khasnis, Andrea Gunnell, Helen M Webb, Claire Shannon-Lowe, Simon Andrews, Cameron S Osborne, Michelle J West
Publikováno v:
eLife, Vol 5 (2016)
Lymphomagenesis in the presence of deregulated MYC requires suppression of MYC-driven apoptosis, often through downregulation of the pro-apoptotic BCL2L11 gene (Bim). Transcription factors (EBNAs) encoded by the lymphoma-associated Epstein-Barr virus
Externí odkaz:
https://doaj.org/article/d0168bf945bb4d54b7a76064f2dbc58e
Autor:
Christel Krueger, Michelle R King, Felix Krueger, Miguel R Branco, Cameron S Osborne, Kathy K Niakan, Michael J Higgins, Wolf Reik
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e38983 (2012)
Although somatic homologous pairing is common in Drosophila it is not generally observed in mammalian cells. However, a number of regions have recently been shown to come into close proximity with their homologous allele, and it has been proposed tha
Externí odkaz:
https://doaj.org/article/5a6cb25828564866ad2bf47bfb7b4369
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16607 (2011)
Massively parallel DNA sequencing is capable of sequencing tens of millions of DNA fragments at the same time. However, sequence bias in the initial cycles, which are used to determine the coordinates of individual clusters, causes a loss of fidelity
Externí odkaz:
https://doaj.org/article/d218d8b954fb4f5e8695406d52a30ee8
Autor:
Cameron S Osborne, Lyubomira Chakalova, Jennifer A Mitchell, Alice Horton, Andrew L Wood, Daniel J Bolland, Anne E Corcoran, Peter Fraser
Publikováno v:
PLoS Biology, Vol 5, Iss 8, p e192 (2007)
Transcription in mammalian nuclei is highly compartmentalized in RNA polymerase II-enriched nuclear foci known as transcription factories. Genes in cis and trans can share the same factory, suggesting that genes migrate to preassembled transcription
Externí odkaz:
https://doaj.org/article/70c4679520954fabb6c965ff8f31b515
Autor:
Joanne Miles, Jennifer A Mitchell, Lyubomira Chakalova, Beatriz Goyenechea, Cameron S Osborne, Laura O'Neill, Keiji Tanimoto, James Douglas Engel, Peter Fraser
Publikováno v:
PLoS ONE, Vol 2, Iss 7, p e630 (2007)
Several lines of evidence have established strong links between transcriptional activity and specific post-translation modifications of histones. Here we show using RNA FISH that in erythroid cells, intergenic transcription in the human beta-globin l
Externí odkaz:
https://doaj.org/article/72f2e31b2e7a4ae8a3f1524cf45d0056
Autor:
William Villiers, Audrey Kelly, Xiaohan He, James Kaufman-Cook, Abdurrahman Elbasir, Halima Bensmail, Paul Lavender, Richard Dillon, Borbála Mifsud, Cameron S. Osborne
Publikováno v:
Nature Communications. 14
The PML::RARA fusion protein is the hallmark driver of Acute Promyelocytic Leukemia (APL) and disrupts retinoic acid signaling, leading to wide-scale gene expression changes and uncontrolled proliferation of myeloid precursor cells. While known to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::293fa1e5d44140fa55ce6ff068e8c876
https://doi.org/10.1038/s41467-023-36262-0
https://doi.org/10.1038/s41467-023-36262-0
Autor:
Oliver M. Dovey, Pedro Madrigal, Paolo Gallipoli, George S. Vassiliou, Haiyang Yun, Cameron S. Osborne, Shuchi Agrawal-Singh, Annalisa Mupo, Shabana Vohra, David Lara-Astiaso, Aracely Castillo-Venzor, Faisal Basheer, Sarah J. Horton, Brian J. P. Huntly, Ludovica Marando, Malgorzata Gozdecka, Eshwar Meduri, Carsten Müller-Tidow, Daniel Sasca, George Giotopoulos, Xiaonan Wang, Nisha Narayan
Publikováno v:
Nature Genetics. 53:1443-1455
Altered transcription is a cardinal feature of acute myeloid leukemia (AML); however, exactly how mutations synergize to remodel the epigenetic landscape and rewire three-dimensional DNA topology is unknown. Here, we apply an integrated genomic appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::167b3ec8428ace067c05deac35f64a8b
https://doi.org/10.1038/s41588-021-00925-9
https://doi.org/10.1038/s41588-021-00925-9
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
It is now evident that DNA forms an organized nuclear architecture, which is essential to maintain the structural and functional integrity of the genome. Chromatin organization can be systematically studied due to the recent boom in chromosome confor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18701e63d18be52eadeee8b1adb5231b
https://www.frontiersin.org/articles/10.3389/fgene.2022.786501/full
https://www.frontiersin.org/articles/10.3389/fgene.2022.786501/full