Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Cameron S Field"'
Autor:
Carole eGrasso, Marie-Sophie eFabre, Sarah V Collis, M Leticia Castro, Cameron S Field, Nanette eSchleich, Melanie J McConnell, Patries M Herst
Publikováno v:
Frontiers in Oncology, Vol 4 (2014)
Pharmacological ascorbate is currently used as an anti-cancer treatment, potentially in combination with radiation therapy, by integrative medicine practitioners. In the acidic, metal-rich tumour environment, ascorbate acts as a pro-oxidant, with a m
Externí odkaz:
https://doaj.org/article/848915498b6a4114a76bea286ab0bafc
Autor:
Joy Edwards-Hicks, Petya Apostolova, Joerg M. Buescher, Hannes Maib, Michal A. Stanczak, Mauro Corrado, Ramon I. Klein Geltink, Maria Elena Maccari, Matteo Villa, Gustavo E. Carrizo, David E. Sanin, Francesc Baixauli, Beth Kelly, Jonathan D. Curtis, Fabian Haessler, Annette Patterson, Cameron S. Field, George Caputa, Ryan L. Kyle, Melanie Soballa, Minsun Cha, Harry Paul, Jacob Martin, Katarzyna M. Grzes, Lea Flachsmann, Michael Mitterer, Liang Zhao, Frances Winkler, David Ali Rafei-Shamsabadi, Frank Meiss, Bertram Bengsch, Robert Zeiser, Daniel J. Puleston, David O’Sullivan, Edward J. Pearce, Erika L. Pearce
Publikováno v:
Nature Immunology
How lipidome changes support CD8+ effector T (Teff) cell differentiation is not well understood. Here we show that, although naive T cells are rich in polyunsaturated phosphoinositides (PIPn with 3-4 double bonds), Teff cells have unique PIPn marked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bcbbf423f9a7b51630fb44cecc15a8
https://hdl.handle.net/21.11116/0000-000D-12D6-D21.11116/0000-000D-12D8-B
https://hdl.handle.net/21.11116/0000-000D-12D6-D21.11116/0000-000D-12D8-B
Autor:
Francesc Baixauli, Klara Piletic, Daniel J. Puleston, Matteo Villa, Cameron S. Field, Lea J. Flachsmann, Andrea Quintana, Nisha Rana, Joy Edwards-Hicks, Mai Matsushita, Michal A. Stanczak, Katarzyna M. Grzes, Agnieszka M. Kabat, Mario Fabri, George Caputa, Beth Kelly, Mauro Corrado, Yaarub Musa, Katarzyna J. Duda, Gerhard Mittler, David O’Sullivan, Hiromi Sesaki, Thomas Jenuwein, Joerg M. Buescher, Edward J. Pearce, David E. Sanin, Erika L. Pearce
Publikováno v:
Nature
CD4+ T cell differentiation requires metabolic reprogramming to fulfil the bioenergetic demands of proliferation and effector function, and enforce specific transcriptional programmes1-3. Mitochondrial membrane dynamics sustains mitochondrial process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b176219f4d5bd0e37689d90bf3777d
https://europepmc.org/articles/PMC9844518/
https://europepmc.org/articles/PMC9844518/
Autor:
Edward J. Pearce, Angela Castoldi, Joerg M. Buescher, Lea J. Flachsmann, Fabian Hässler, Ryan Kyle, Annette E. Patterson, David E. Sanin, Daniel J. Puleston, Alanna M. Cameron, Beth Kelly, Cameron S. Field, Erika L. Pearce
Publikováno v:
Nature Immunology
The adoption of Warburg metabolism is critical for the activation of macrophages in response to lipopolysaccharide. Macrophages stimulated with lipopolysaccharide increase their expression of nicotinamide phosphoribosyltransferase (NAMPT), a key enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5895c6ceaa0e9c3d8512fd15778243
https://doi.org/10.1038/s41590-019-0336-y
https://doi.org/10.1038/s41590-019-0336-y
Autor:
David, O'Sullivan, Michal A, Stanczak, Matteo, Villa, Franziska M, Uhl, Mauro, Corrado, Ramon I, Klein Geltink, David E, Sanin, Petya, Apostolova, Nisha, Rana, Joy, Edwards-Hicks, Katarzyna M, Grzes, Agnieszka M, Kabat, Ryan L, Kyle, Mario, Fabri, Jonathan D, Curtis, Michael D, Buck, Annette E, Patterson, Annamaria, Regina, Cameron S, Field, Francesc, Baixauli, Daniel J, Puleston, Edward J, Pearce, Robert, Zeiser, Erika L, Pearce
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Fever is a common symptom of infections and inflammation. We observed CD8+ T cells exposed to febrile-range temperature during activation, augmented mitochondrial mass, and metabolic activity. An adoptive transfer of these cells into tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::992c62d2a4b6bd0db956a8d0724ea9df
https://pubmed.ncbi.nlm.nih.gov/34161266
https://pubmed.ncbi.nlm.nih.gov/34161266
Autor:
Michael D. Buck, Daniel J. Puleston, Mario Fabri, Agnieszka M. Kabat, Katarzyna M. Grzes, Annamaria Regina, Michal A. Stanczak, Francesc Baixauli, Annette E. Patterson, Erika L. Pearce, Ryan Kyle, Joy Edwards-Hicks, Robert Zeiser, Ramon I. Klein Geltink, David E. Sanin, Petya Apostolova, David O’Sullivan, Jonathan D. Curtis, Cameron S. Field, Edward J. Pearce, Franziska M. Uhl, Matteo Villa, Mauro Corrado, Nisha Rana
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Fever can provide a survival advantage during infection. Metabolic processes are sensitive to environmental conditions, but the effect of fever on T cell metabolism is not well characterized. We show that in activated CD8+ T cells, exposure to febril
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2631fec13f3e1f503b296a359e19642
https://doi.org/10.1073/pnas.2023752118
https://doi.org/10.1073/pnas.2023752118
Autor:
Benjamin J. Compton, Carole Grasso, Ian F. Hermans, Michael V. Berridge, Ching-Wen Tang, Regan J. Anderson, Cameron S. Field, Gavin F. Painter, Robert Weinkove, Peter M. Ferguson
Publikováno v:
Immunotherapy. 12(6)
Aim: The efficacy of anti-lymphoma vaccines that exploit the cellular adjuvant properties of activated natural killer T (NKT) cells were examined in mouse models of CNS lymphoma. Materials & methods: Vaccines were prepared by either loading the NKT c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f0defe907a59363f5d14f87e9923cc
https://pubmed.ncbi.nlm.nih.gov/32316797
https://pubmed.ncbi.nlm.nih.gov/32316797
Autor:
Cameron S. Field, Marcin Kamiński, Francesc Baixauli, Edward J. Pearce, Douglas R. Green, Stanckzak M, Yaarub Musa, Schimmelpfennig L, Chong Wang, Erika L. Pearce, Matteo Villa, Katarzyna M. Grzes, Joerg M. Buescher, Vijay K. Kuchroo, Lea J. Flachsmann, Fabian Hässler, Agnieszka M. Kabat, Gerhard Mittler, Daniel J. Puleston, David E. Sanin, Weiss H, Nir Yosef, Stefan Balabanov
SUMMARYWe report here a central role for polyamines in T cell differentiation and function. Deficiency in ornithine decarboxylase (ODC), a critical enzyme for polyamine synthesis, resulted in a profound failure of CD4+ T cells to adopt correct subset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc853f69460a68a0c83eaf866e22e6a
https://doi.org/10.1101/2020.01.24.918094
https://doi.org/10.1101/2020.01.24.918094
Autor:
Joerg M. Buescher, Michal Stanckzak, Hauke J. Weiss, Klara Piletic, Daniel J. Puleston, Mauro Corrado, Marcin Kamiński, Matteo Villa, Joy Edwards-Hicks, Fabian Haessler, Douglas R. Green, Cameron S. Field, Lena Schimmelpfennig, Katarzyna M. Grzes, Chao Wang, David E. Sanin, Vijay K. Kuchroo, Edward J. Pearce, Nir Yosef, Stefan Balabanov, Lea J. Flachsmann, Francesc Baixauli, Yaarub Musa, Erika L. Pearce, Agnieszka M. Kabat, Gerhard Mittler
Publikováno v:
Cell
Summary Polyamine synthesis represents one of the most profound metabolic changes during T cell activation, but the biological implications of this are scarcely known. Here, we show that polyamine metabolism is a fundamental process governing the abi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a75b416681722202457cc395d1afb1c
https://doi.org/10.1016/j.cell.2021.06.007
https://doi.org/10.1016/j.cell.2021.06.007
Autor:
David E. Sanin, Ramon I. Klein Geltink, Jing Qiu, George Caputa, Katarzyna M. Grzes, David O’Sullivan, Alanna M. Cameron, Yaarub Musa, Jonathan D. Curtis, Stefanie Scherer, Mauro Corrado, Francesca Alfei, Beth Kelly, Mai Matsushita, Matteo Villa, Nora Pällman, Michael D. Buck, Agnieszka M. Kabat, Edward J. Pearce, Annette E. Patterson, Francesc Baixauli, Joerg M. Buescher, Gerhard Mittler, S. Kyle Austin, Dietmar Zehn, Katelyn Paz, Erika L. Pearce, Ryan Kyle, Cameron S. Field, Sabine Rospert, Lea J. Flachsmann, Ying Zhang, Daniel J. Puleston, Maria Elena Maccari, Angela Castoldi, Stefan Balabanov, Bruce R. Blazar
Publikováno v:
Cell Metabolism
Summary How cells adapt metabolism to meet demands is an active area of interest across biology. Among a broad range of functions, the polyamine spermidine is needed to hypusinate the translation factor eukaryotic initiation factor 5A (eIF5A). We sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bb9061e9b120f7fcc36a04cbbe2d8c
https://hdl.handle.net/21.11116/0000-0004-A643-521.11116/0000-0006-40A4-8
https://hdl.handle.net/21.11116/0000-0004-A643-521.11116/0000-0006-40A4-8