Dengue viremia kinetics and effects on platelet count and clinical outcomes: An analysis of 2340 patients from Vietnam

Autor: Nguyen Lam Vuong, Nguyen Than Ha Quyen, Nguyen Thi Hanh Tien, Kien Duong Thi Hue, Huynh Thi Le Duyen, Phung Khanh Lam, Dong Thi Hoai Tam, Tran Van Ngoc, Thomas Jaenisch, Cameron P Simmons, Sophie Yacoub, Bridget A Wills, Ronald Geskus

Publikováno v: eLife, Vol 13 (2024)

Background: Viremia is a critical factor in understanding the pathogenesis of dengue infection, but limited data exist on viremia kinetics. This study aimed to investigate the kinetics of viremia and its effects on subsequent platelet count, severe d

Externí odkaz: https://doaj.org/article/71169484fc9143f99ecd04ae600ee09c

Reduced dengue incidence following city-wide wMel Wolbachia mosquito releases throughout three Colombian cities: Interrupted time series analysis and a prospective case-control study.

Autor: Ivan Dario Velez, Stephanie K Tanamas, Maria Patricia Arbelaez, Simon C Kutcher, Sandra L Duque, Alexander Uribe, Lina Zuluaga, Luis Martínez, Ana Cristina Patiño, Jovany Barajas, Estefanía Muñoz, Maria Camila Mejia Torres, Sandra Uribe, Sandra Porras, Rita Almanza, Henry Pulido, Scott L O'Neill, Eduardo Santacruz-Sanmartin, Sandra Gonzalez, Peter A Ryan, Jai A Denton, Nicholas P Jewell, Suzanne M Dufault, Cameron P Simmons, Katherine L Anders

Publikováno v: PLoS Neglected Tropical Diseases, Vol 17, Iss 11, p e0011713 (2023)

BackgroundThe introduction of Wolbachia (wMel strain) into Aedes aegypti mosquitoes reduces their capacity to transmit dengue and other arboviruses. Randomised and non-randomised studies in multiple countries have shown significant reductions in deng

Externí odkaz: https://doaj.org/article/3531382218da43138231d593291254b2

Direct mosquito feedings on dengue-2 virus-infected people reveal dynamics of human infectiousness.

Autor: Louis Lambrechts, Robert C Reiner, M Veronica Briesemeister, Patricia Barrera, Kanya C Long, William H Elson, Alfonso Vizcarra, Helvio Astete, Isabel Bazan, Crystyan Siles, Stalin Vilcarromero, Mariana Leguia, Anna B Kawiecki, T Alex Perkins, Alun L Lloyd, Lance A Waller, Uriel Kitron, Sarah A Jenkins, Robert D Hontz, Wesley R Campbell, Lauren B Carrington, Cameron P Simmons, J Sonia Ampuero, Gisella Vasquez, John P Elder, Valerie A Paz-Soldan, Gonzalo M Vazquez-Prokopec, Alan L Rothman, Christopher M Barker, Thomas W Scott, Amy C Morrison

Publikováno v: PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011593 (2023)

Dengue virus (DENV) transmission from humans to mosquitoes is a poorly documented, but critical component of DENV epidemiology. Magnitude of viremia is the primary determinant of successful human-to-mosquito DENV transmission. People with the same le

Externí odkaz: https://doaj.org/article/fef72510ea194d4f8ba41bcc397acb54

Early diagnostic indicators of dengue versus other febrile illnesses in Asia and Latin America (IDAMS study): a multicentre, prospective, observational study

Autor: Kerstin D Rosenberger, PhD, Lam Phung Khanh, MD PhD, Frank Tobian, MSc, Ngoun Chanpheaktra, MD, Varun Kumar, MD, Lucy Chai See Lum, ProfMRCP, Jameela Sathar, MD, Ernesto Pleiteés Sandoval, MD, Gabriela M Maroén, MD, Ida Safitri Laksono, MD PhD, Yodi Mahendradhata, MD PhD, Malabika Sarker, ProfMD PhD, Ridwanur Rahman, ProfFCPS, Andrea Caprara, ProfMD PhD, Bruno Souza Benevides, MD PhD, Ernesto T A Marques, ProfMD PhD, Tereza Magalhaes, PhD, Patrícia Brasil, ProfMD PhD, Guilherme Amaral Calvet, MD PhD, Adriana Tami, MD PhD, Sarah E Bethencourt, PhD, Tam Dong Thi Hoai, MD PhD, Kieu Nguyen Tan Thanh, MPharm, Ngoc Tran Van, MD, Nam Nguyen Tran, MD, Viet Do Chau, MD, Sophie Yacoub, MD PhD, Kinh Nguyen Van, ProfMD PhD, María G Guzmán, ProfMD PhD, Pedro A Martinez, MD PhD, Quyen Nguyen Than Ha, PhD, Cameron P Simmons, ProfPhD, Bridget A Wills, ProfFRCPCH, Ronald B Geskus, PhD, Thomas Jaenisch, MD PhD, Zabir Hasan, Kilma Wanderley Lopes Gomes, Lyvia Patricia Soares Mesquita, Cynthia Braga, Priscila M.S. Castanha, Marli T. Cordeiro, Luana Damasceno, Bophal Chuop, Sonyrath Ouk, Reaksmey Sin, Sopheary Sun, Mayling Alvarez Vera, Guillermo Barahona, Bladimir Cruz, Dorothea Beck, Roger Gaczkowski, Thomas Junghanss, Ivonne Morales, Marius Wirths, Santha Kumari Natkunam, Bee Kiau Ho, Sazaly AbuBakar, Juraina Abd-Jamil, Sharifah Faridah Syed Omar, Erley F. Lizarazo, María F. Vincenti-González, Robert Tovar, Tam Cao Thi, Hong Dinh Thi Tri, Huy Huynh Le Anh, Duyen Huynh Thi Le, Thanh Lai Thi Cong, Van Nguyen Thi Hong, Linh Nguyen Thi My, Thuy Tran Thi Nhu, Thuy Truong Thi Thu, Nuoi Banh Thi, Trinh Huynh Lam Thuy, Hiep Nguyen Thi Thu, Van Tran Thi Kim, Luan Vo Thanh, Bich Dang Thi, Huong Dinh Thi Thu, Huy Dinh Van, Huyen Nguyen Nguyen, Huong Vu Thi Thu

Publikováno v: The Lancet Global Health, Vol 11, Iss 3, Pp e361-e372 (2023)

Summary: Background: Improvements in the early diagnosis of dengue are urgently needed, especially in resource-limited settings where the distinction between dengue and other febrile illnesses is crucial for patient management. Methods: In this prosp

Externí odkaz: https://doaj.org/article/4f9011bd23b046f4b14bc9e277d528be

Applied machine learning for the risk-stratification and clinical decision support of hospitalised patients with dengue in Vietnam.

Autor: Damien K Ming, Bernard Hernandez, Sorawat Sangkaew, Nguyen Lam Vuong, Phung Khanh Lam, Nguyen Minh Nguyet, Dong Thi Hoai Tam, Dinh The Trung, Nguyen Thi Hanh Tien, Nguyen Minh Tuan, Nguyen Van Vinh Chau, Cao Thi Tam, Ho Quang Chanh, Huynh Trung Trieu, Cameron P Simmons, Bridget Wills, Pantelis Georgiou, Alison H Holmes, Sophie Yacoub, Vietnam ICU Translational Applications Laboratory (VITAL) investigators

Publikováno v: PLOS Digital Health, Vol 1, Iss 1, p e0000005 (2022)

BackgroundIdentifying patients at risk of dengue shock syndrome (DSS) is vital for effective healthcare delivery. This can be challenging in endemic settings because of high caseloads and limited resources. Machine learning models trained using clini

Externí odkaz: https://doaj.org/article/baf8220fecff40a8888cec9897258431