Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Cameron Millar"'
Publikováno v:
Royal Society Open Science, Vol 8, Iss 6 (2021)
This paper presents a graphical method for determining the linearized stiffness and stability of prestressed trusses consisting of rigid bars connected at pinned joints and which possess kinematic freedoms. Key to the construction are the rectangular
Externí odkaz:
https://doaj.org/article/6d813cb921b54824a409543f7ddff5e7
Autor:
Shruti V. Patil, Balasankara Reddy Kaipa, Sujata Ranshing, Yogapriya Sundaresan, J. Cameron Millar, Bhavani Nagarajan, Charles Kiehlbauch, Qihong Zhang, Ankur Jain, Charles C. Searby, Todd E. Scheetz, Abbot F. Clark, Val C. Sheffield, Gulab S. Zode
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Mutations in myocilin (MYOC) are the leading known genetic cause of primary open-angle glaucoma, responsible for about 4% of all cases. Mutations in MYOC cause a gain-of-function phenotype in which mutant myocilin accumulates in the endoplas
Externí odkaz:
https://doaj.org/article/30e1fedfb0d445a39df2b98bbdbfd4a5
Autor:
Prabhavathi Maddineni, Ramesh B. Kasetti, Pinkal D. Patel, J. Cameron Millar, Charles Kiehlbauch, Abbot F. Clark, Gulab S. Zode
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-20 (2020)
Abstract Background Glaucoma is a leading neurodegenerative disease affecting over 70 million individuals worldwide. Early pathological events of axonal degeneration and retinopathy in response to elevated intraocular pressure (IOP) are limited and n
Externí odkaz:
https://doaj.org/article/5d98db75107e4e73813752674e1ac9f3
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 516 (2022)
Mutations in PITX2 cause Axenfeld–Rieger syndrome, with congenital glaucoma as an ocular feature. The egl1 mouse strain carries a chemically induced Pitx2 mutation and develops early-onset glaucoma. In this study, we characterized the glaucomatous
Externí odkaz:
https://doaj.org/article/5da54c34c5664a05b5fde23932127530
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 6883
Glaucoma is a multifactorial disease leading to irreversible blindness. Primary open-angle glaucoma (POAG) is the most common form and is associated with the elevation of intraocular pressure (IOP). Reduced aqueous humor (AH) outflow due to trabecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abec35223781071c03be53106d801724
Publikováno v:
Structural Engineering International, (2022)
The newly-developed method of graphic stability is applied to Robert Maillart’s iconic roof design at Chiasso. The truss has an unusual form which emerged from Maillart’s graphic statics as the shape dual to the symmetrical equilibrium forces. Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4ab341101aa08037d13d4f3a62f3d6
https://hdl.handle.net/2078.1/254754
https://hdl.handle.net/2078.1/254754
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose In POAG, elevated IOP remains the major risk factor in irreversible vision loss. Increased TGFβ2 expression in POAG aqueous humor and in the trabecular meshwork (TM) amplifies extracellular matrix (ECM) deposition and reduces ECM turnover in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d44b888717655201548ce7319b5de05
https://pubmed.ncbi.nlm.nih.gov/33938911
https://pubmed.ncbi.nlm.nih.gov/33938911
Autor:
Yen Lin Chen, J. Cameron Millar, Dorette Z. Ellis, Pinkal D. Patel, Prabhavathi Maddineni, Gulab S. Zode, Ramesh B. Kasetti, Swapnil K. Sonkusare, William Mayhew
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Primary Open Angle Glaucoma (POAG) is the most common form of glaucoma that leads to irreversible vision loss and blindness worldwide. POAG is often associated with elevated intraocular pressure (IOP). The trabecular meshwork (TM), a mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5ec69894e80755b4d6d43e776699678
https://pubmed.ncbi.nlm.nih.gov/33853948
https://pubmed.ncbi.nlm.nih.gov/33853948
Autor:
Dorota L, Stankowska, J Cameron, Millar, Bindu, Kodati, Sumita, Behera, Renuka M, Chaphalkar, Tam, Nguyen, Kytai T, Nguyen, Raghu R, Krishnamoorthy, Dorette Z, Ellis, Suchismita, Acharya
Publikováno v:
Molecular Vision
Purpose Glaucoma is a neurodegenerative disease of the eye with an estimated prevalence of more than 111.8 million patients worldwide by 2040, with at least 6 to 8 million projected to become bilaterally blind. Clinically, the current method of slowi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44fa3e68e02821b4c84cac94aaff8547
https://pubmed.ncbi.nlm.nih.gov/33633438
https://pubmed.ncbi.nlm.nih.gov/33633438
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 11, p e0241294 (2020)
PLoS ONE, Vol 15, Iss 11, p e0241294 (2020)
PurposeSecreted protein acidic and rich in cysteine (SPARC) is a matricellular protein that regulates intraocular pressure (IOP) by altering extracellular matrix (ECM) homeostasis within the trabecular meshwork (TM). We hypothesized that the lower IO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e758f70d46303df98571369c83a582bf
https://pubmed.ncbi.nlm.nih.gov/33147244
https://pubmed.ncbi.nlm.nih.gov/33147244