Výsledky vyhledávání - "Cameron McElroy"

Akademický článek

Neurofilament light chain and dorsal root ganglia injury after adeno-associated virus 9 gene therapy in nonhuman primates

Autor: Eric W. Johnson, Jeffrey J. Sutherland, Emily Meseck, Cameron McElroy, Deepa H. Chand, Francis Fonyuy Tukov, Eloise Hudry, Kelley Penraat

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 208-219 (2023)

In nonhuman primates (NHPs), adeno-associated virus serotype 9 (AAV9) vectorized gene therapy can cause asymptomatic microscopic injury to dorsal root ganglia (DRG) and trigeminal ganglia (TG) somatosensory neurons, causing neurofilament light chain

Externí odkaz: https://doaj.org/article/ff357e0c44fd444d815f1c28922732c0

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Intrathecal sc-AAV9-CB-GFP: Systemic Distribution Predominates Following Single-Dose Administration in Cynomolgus Macaques

Autor: Eloise Hudry, Ghiabe Guibinga, Keith Mansfield, Emily K. Meseck, Stephen Wang, Cameron McElroy

Publikováno v: Toxicologic pathology. 50(4)

Biodistribution of self-complementary adeno-associated virus-9 (scAAV9)–chicken β-actin promoter–green fluorescent protein (GFP) was assessed in juvenile cynomolgus macaques infused intrathecally via lumbar puncture or the intracisterna magna (1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6addedbe2b63e6482deef1f302eaa4e7
https://pubmed.ncbi.nlm.nih.gov/35658751

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