Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Cameron McDonald Hyman"'
Autor:
Govindarajan Thangavelu, Gabriela Andrejeva, Sara Bolivar-Wagers, Sujeong Jin, Michael C. Zaiken, Michael Loschi, Ethan G. Aguilar, Scott N. Furlan, Chrysothemis C. Brown, Yu-Chi Lee, Cameron McDonald Hyman, Colby J. Feser, Angela Panoskaltsis-Mortari, Keli L. Hippen, Kelli P. MacDonald, William J. Murphy, Ivan Maillard, Geoffrey R. Hill, David H. Munn, Robert Zeiser, Leslie S. Kean, Jeffrey C. Rathmell, Hongbo Chi, Randolph J. Noelle, Bruce R. Blazar
Publikováno v:
Cell Mol Immunol
Regulatory T cells (Tregs) promote immune homeostasis by maintaining self-tolerance and regulating inflammatory responses. Under certain inflammatory conditions, Tregs can lose their lineage stability and function. Previous studies have reported that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d110cf2e2d9fae40894c6c0e171897a6
https://doi.org/10.1038/s41423-022-00869-y
https://doi.org/10.1038/s41423-022-00869-y
Autor:
Jemma H. Larson, Sujeong Jin, Michael Loschi, Sara Bolivar Wagers, Govindarajan Thangavelu, Michael C. Zaiken, Cameron McDonald-Hyman, Asim Saha, Ethan G. Aguilar, Brent Koehn, Mark J. Osborn, Angela Panoskaltsis-Mortari, Kelli P.A. Macdonald, Geoffrey R. Hill, William J. Murphy, Jonathan S. Serody, Ivan Maillard, Leslie S. Kean, Sangwon V. Kim, Dan R. Littman, Bruce R. Blazar
Publikováno v:
American Journal of Transplantation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81b928a597031c33223a95da375a8d70
https://doi.org/10.1016/j.ajt.2023.01.030
https://doi.org/10.1016/j.ajt.2023.01.030
Autor:
Randolph J. Noelle, Roshantha A.S. Chandraratna, Amanda Janesick, Ethan G. Aguilar, Kelli P. A. MacDonald, Asim Saha, Bruce R. Blazar, Keli L. Hippen, Michael Loschi, Govindarajan Thangavelu, Kazutoshi Aoyama, Geoffrey R. Hill, Angela Panoskaltsis-Mortari, Vijay K. Kuchroo, Yosef Refaeli, Bruce Blumberg, Chrysothemis C. Brown, Scott N. Furlan, William J. Murphy, David H. Munn, Jonathan S. Serody, Cameron McDonald-Hyman, Chao Wang, Ivan Maillard, Leslie S. Kean, Robert Zeiser, Mark J. Osborn
Publikováno v:
Blood. 137:1090-1103
The nuclear receptor (NR) subclass, retinoid X receptors (RXRs), exert immunomodulatory functions that control inflammation and metabolism via homodimers and heterodimers, with several other NRs, including retinoic acid receptors. IRX4204 is a novel,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad0f3302c269d7174eef13fea11aefd7
https://doi.org/10.1182/blood.2020005628
https://doi.org/10.1182/blood.2020005628
Autor:
Cameron McDonald-Hyman, Ethan Aquilar, Stephanie Rhee, Fathima Mohamed, Ewaldus Compeer, Michael Dustin, Keli Lee Hippen, Bruce R. Blazar
Publikováno v:
Blood. 140:4459-4460
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e3d6b58c136cdc61331ebc9f641abd9
https://doi.org/10.1182/blood-2022-160475
https://doi.org/10.1182/blood-2022-160475
Autor:
Jonathan S. Serody, Ameeta Kelekar, Brent H. Koehn, Brian T. Fife, Laurence A. Turka, Asim Saha, Govindarajan Thangavelu, Keli L. Hippen, Sudha Kumari, Angela Panoskaltsis-Mortari, Andrew Kemal Kirchmeier, Mark J. Osborn, Cameron McDonald-Hyman, David H. Munn, Jason S. Mitchell, Guoan Zhang, Bruce R. Blazar, Colby J. Feser, Michael Loschi, Michael L. Dustin, Jiqiang Lin, James E. Muller, Thomas A. Neubert, Hongbo Chi, Michelle J. Smith, Dawn K. Reichenbach
Publikováno v:
Journal of Clinical Investigation. 128:4604-4621
Regulatory T cells (Tregs) are critical for maintaining immune homeostasis. However, current Treg immunotherapies do not optimally treat inflammatory diseases in patients. Understanding the cellular processes that control Treg function may allow for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa9aa562335b3f5723f28fc2098183a
https://doi.org/10.1172/jci95713
https://doi.org/10.1172/jci95713
Autor:
Jonathan S. Serody, Jenny P.-Y. Ting, Christopher J. Farady, Vincenzo Bronte, Michael Loschi, Brent H. Koehn, Takao Iwawaki, Asim Saha, Govindarajan Thangavelu, Mark E. Cooper, Cameron McDonald-Hyman, Jamie Panthera, Lie Ma, Keli L. Hippen, Walker Krepps, Bruce R. Blazar, Josh Dysthe, Jeffrey S. Miller, Stephen C. Jameson, Robert Zeiser, Peter J. Murray, William J. Murphy, David H. Munn, Michael Zaiken, Geoffrey R. Hill
Myeloid-derived suppressor cells (MDSCs) can subdue inflammation. In mice with acute graft-versus-host disease (GVHD), donor MDSC infusion enhances survival that is only partial and transient because of MDSC inflammasome activation early posttransfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3540affa97b6d7dccadd3d19f16faf4a
Autor:
Jemma H Nicholls, Michael Loschi, Sujeong Jin, Sara Bolivar Wagers, Govindarajan Thangavelu, Michael C Zaiken, Cameron McDonald-Hyman, Asim Saha, Ethan G Aguliar, Brent Koehn, Mark J Osborn, Kelli P.A. MacDonald, Sangwon V Kim, Dan R Littman, Bruce R Blazar
Publikováno v:
The Journal of Immunology. 206:11.05-11.05
Damage to the gastrointestinal (GI) tract following hematopoietic stem cell transplant (HSCT) has been shown to drive the development of acute graft-versus-host disease (aGVHD). We have demonstrated clinically that infusing regulatory T-cells (Treg)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b47631cc75e8e92e357a6781f42626cf
https://doi.org/10.4049/jimmunol.206.supp.11.05
https://doi.org/10.4049/jimmunol.206.supp.11.05
Autor:
Govindarajan Thangavelu, Gabriela Andrejeva, Michael Loschi, Ethan G Aguilar, Yu-Chi Lee, Scott N Furlan, Cameron McDonald-Hyman, Michael C Zaiken, Colby J Feser, Angela Panoskaltsis-Mortari, Leslie S Kean, Jeffrey C Rathmell, Hongbo Chi, Randolph J Noelle, Bruce R Blazar
Publikováno v:
The Journal of Immunology. 204:228.4-228.4
Regulatory T cells (Tregs) modulate immune responses to maintain immune homeostasis. Retinoic acid (RA) signaling promotes Treg generation and stability. Paradoxically, we observed that dominant negative RA receptor α expressed only in donor T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e00706aab58132dd958938233196adb
https://doi.org/10.4049/jimmunol.204.supp.228.4
https://doi.org/10.4049/jimmunol.204.supp.228.4
Autor:
Yosef Refaeli, Jessie L. Barnum, Angela Panoskaltsis-Mortari, Jeffrey S. Miller, Heather Campbell, Zhengming Xiong, Govindarajan Thangavelu, Scott N. Furlan, Mark J. Osborn, Megan J. Riddle, Michael C. Jensen, Christopher A. Pennell, Cameron McDonald-Hyman, Bruce R. Blazar, Leslie S. Kean, Meghan D. Storlie, Michael Loschi, Jakub Tolar
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 26(6)
The clinical success of chimeric antigen receptor (CAR) T cell therapy for CD19(+) B cell malignancies can be limited by acute toxicities and immunoglobulin replacement needs due to B cell aplasia from persistent CAR T cells. Life-threatening complic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66399fea358dca9cf5cfda860aa36209
https://pubmed.ncbi.nlm.nih.gov/29784587
https://pubmed.ncbi.nlm.nih.gov/29784587
Autor:
Mark J. Osborn, Katharina Kreymborg, Jonathan S. Serody, James P. Allison, Patricia A. Taylor, Annette Schmitt-Graeff, Cameron McDonald-Hyman, Elisabeth Lieberknecht, Gordon J. Freeman, Marcel R.M. van den Brink, Angela Panoskaltsis-Mortari, Ryan Flynn, Asim Saha, Bruce R. Blazar, William J. Murphy, David H. Munn, Rachelle G. Veenstra, Tak W. Mak, Robert Zeiser
Publikováno v:
Blood. 125:3335-3346
Members of the B7 family have been shown to be important for regulating immune responses by providing either positive or negative costimulatory signals. The function of B7-H3 has been controversial. We show that B7-H3 is upregulated in graft-versus-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c2d018300e63eebcbba393a33b8a5f
https://doi.org/10.1182/blood-2014-09-603357
https://doi.org/10.1182/blood-2014-09-603357